Mechanisms of Rutin Pharmacological Action (Review)

Ковальский, Иван Васильевич; Krasnyuk, I. I.; Nikulina, O. I.; Belyatskaya, A. V.; Kharitonov, Yu. Ya.; Feldman, Nataliya B.; Луценко, С. В.

doi:10.1007/s11094-014-1050-6

Cited by 67 publications

(24 citation statements)

References 42 publications

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“…Flavonoids in plants are usually combined with sugar to form glycosides, and a small number of these exists in the form of aglycones. Rutin (Table ), a glycoside between quercetin and disaccharide rutinose (α‐ l ‐rhamnopyranosyl‐(1 → 6)‐β‐ d ‐glucopyranose), is a flavonol that is found in many plants and which has many biological activities, for example as an antioxidant, and as anti‐inflammation, anti‐microbial, anti‐tumor or anti‐asthma agents . Quercetin (Table ) is the most abundant flavonoid and forms the backbone for many other flavonoids including the citrus flavonoids such as rutin, hesperidins, naringenin or tangeritin.…”

Section: Introductionmentioning

confidence: 99%

Binding of fluphenazine with human serum albumin in the presence of rutin and quercetin: An evaluation of food‐drug interaction by spectroscopic techniques

et al. 2017

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The interactions between human serum albumin (HSA) and fluphenazine (FPZ) in the presence or absence of rutin or quercetin were studied by fluorescence, absorption and circular dichroism (CD) spectroscopy and molecular modeling. The results showed that the fluorescence quenching mechanism was static quenching by the formation of an HSA-FPZ complex. Entropy change (ΔS ) and enthalpy change (ΔH ) values were 68.42 J/(mol⋅K) and -4.637 kJ/mol, respectively, which indicated that hydrophobic interactions and hydrogen bonds played major roles in the acting forces. The interaction process was spontaneous because the Gibbs free energy change (ΔG ) values were negative. The results of competitive experiments demonstrated that FPZ was mainly located within HSA site I (sub-domain IIA). Molecular docking results were in agreement with the experimental conclusions of the thermodynamic parameters and competition experiments. Competitive binding to HSA between flavonoids and FPZ decreased the association constants and increased the binding distances of FPZ binding to HSA. The results of absorption, synchronous fluorescence, three-dimensional fluorescence, and CD spectra showed that the binding of FPZ to HSA caused conformational changes in HSA and simultaneous effects of FPZ and flavonoids induced further HSA conformational changes.

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Section: Introductionmentioning

confidence: 99%

Binding of fluphenazine with human serum albumin in the presence of rutin and quercetin: An evaluation of food‐drug interaction by spectroscopic techniques

et al. 2017

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“…It is a major component of Chinese medicinal herb Scutellaria baicalensis (Huang-chin) . Rutin is known to exhibit multiple pharmacological activities including antioxidant, anti-inflammation, anti-microbial, anti-tumor and anti-asthma (Chua, 2013;Koval'skii et al, 2014). Similarly, baicalin has been reported to show widely pharmacological and therapeutic properties including antiinflammatory, anti-adipogenesis, anti-asthma, anti-tumor, antibacterial and anti-diarrhea Cui et al, 2014;Ma et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic investigation on the food components–drug interaction: The influence of flavonoids on the affinity of nifedipine to human serum albumin

Wang

Liu

et al. 2015

Food and Chemical Toxicology

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“…The 70% acetone extract of the inner barks of S. japonica was partitioned with a series of solvents to give Earlier pharmaceutical and biological studies reported that rutin ( I ) could interact with free radicals and various protein systems to exhibit antioxidant, anti-inflammatory, anti-allergy, and antitumor activities ( Koval ' skii et al 2014 ). Kaempferol-3-O -(6 ″ -galloyl)-β -glucopyranoside ( II ) inhibited the strain of Candida albicans and thus could be used as an antimicrobial agent ( De Leo et al 2004 ).…”

Section: Resultsmentioning

confidence: 99%

A new cis-p-coumaroyl flavonol glycoside from the inner barks of Sophora japonica L.

Si¹,

et al. 2015

Holzforschung

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A new cis -p -coumaroyl flavonol glycoside from the inner barks of Sophora japonica L.Abstract : Tree barks could be a rich source of novel bioactive compounds, which are not well explored. In this work, the chemical constituent investigation of extractives from the inner barks of Sophora japonica L. (Leguminosae) led to the isolation of a new cis -p -coumaroyl flavonol glycoside, which was elucidated as kaempferol 3-O -(4 ″ -cisp -coumaroyl)-α -rhamnopyranoside ( IV ). The structure of the new compound was established mainly based on extensive spectroscopic techniques. In addition, among the four known phenolics purified in this study, including three flavonol glycosides [rutin ( I ), kaempferol-3-O -(6 ″ -galloyl)-β -glucopyranoside ( II ), and quercitrin ( V )], as well as a phenolic acid [ trans -ferulic acid ( III )], compounds II and III have never been reported in S. japonica previously.

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Mechanisms of Rutin Pharmacological Action (Review)

Cited by 67 publications

References 42 publications

Binding of fluphenazine with human serum albumin in the presence of rutin and quercetin: An evaluation of food‐drug interaction by spectroscopic techniques

Binding of fluphenazine with human serum albumin in the presence of rutin and quercetin: An evaluation of food‐drug interaction by spectroscopic techniques

Spectroscopic investigation on the food components–drug interaction: The influence of flavonoids on the affinity of nifedipine to human serum albumin

A new cis-p-coumaroyl flavonol glycoside from the inner barks of Sophora japonica L.

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