Mechanisms of sudden cardiac death

McElwee, Samuel; Velasco, Alejandro; Doppalapudi, Harish

doi:10.1007/s12350-016-0600-6

Cited by 31 publications

(19 citation statements)

References 57 publications

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“…With the rapid development of imaging diagnostic technology, the detection rate of myocardial ischemia caused by MB has increased recently[26,27]. CTA has been widely used in MB detection, and it has been proved to non-invasively measure the length and thickness of MB, the systolic and diastolic pressure on MCA, and other MB anatomical features[28,29]. Therefore, in the present study, 288 patients with MB were screened from 1718 patients with suspected CHD.…”

Section: Discussionmentioning

confidence: 99%

Myocardial bridge-related coronary heart disease: Independent influencing factors and their predicting value

Zhao

Fan

Ning

et al. 2019

WJCC

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BACKGROUND Myocardial bridge (MB) will compress the mural coronary artery (MCA) during the systole and cause myocardial ischemia. In the diagnosis of coronary heart disease (CHD), because the structure of MB is difficult to be observed by coronary angiography (CAG), the clinical study of the influence of MB on CHD is lacking. With the advancement of computed tomography coronary angiography technology, detailed observations of the MB anatomy have realized. AIM To explore the main influencing factors of MB-related CHD and to find potential indicators for predicting MB-related CHD. METHODS A total of 1718 patients with suspected CHD due to the symptoms of myocardial ischemia were enrolled as subjects. Patients diagnosed with CHD were included in a CHD group, and patients with no significant abnormalities were included in a control group. In the CHD group, patients were divided into an MB-CHD subgroup if MB-related CHD was found. In the control group, patients were divided into a simple MB subgroup if MB was found. The patient's clinical data and MB-related indicators, including the branch of MB, MB type (superficial/deep type), MB length, MB thickness, systolic and diastolic compression of the MCA, and MCA systolic stenosis rate were recorded and compared. Logistic regression analysis was used to explore the independent influencing factors of MD-related CHD. ROC curve was used to analyze the diagnostic efficacy of potential indicators for MB-related CHD. RESULTS There were 1060 cases in the CHD group and 658 cases in the control group, and there were 236 cases in the MB-CHD subgroup and 52 cases in the simple MB subgroup. Multivariate logistic regression analysis showed that the combined MB had a significant effect on the occurrence of CHD ( P < 0.05). MB thickness, systolic compression, diastolic compression, and MCA systolic stenosis rate had significant effects on the occurrence of MB-related CHD ( P < 0.05). The area under the curve (AUC) of the combination of these influencing factors for the diagnosis of MB-related CHD was 0.959, which was significantly higher than the AUCs of the four indicators separately ( P < 0.05). The sensitivity was 97.06% and the specificity was 87.63%. CONCLUSION MB thickness, systolic compression, diastolic compression, and MCA systolic stenosis are independent influencing factors for MB-related CHD. The combination of these factors has potential diagnostic value for MB-related CHD.

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Section: Discussionmentioning

confidence: 99%

Myocardial bridge-related coronary heart disease: Independent influencing factors and their predicting value

Zhao

Fan

Ning

et al. 2019

WJCC

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“…9 Various ECG-based criteria have been proposed, including microvolt T-wave alternans, signal-averaged ECG, QRS fragmentation, and various measures of autonomic (dys-)function such as heart rate variability. 10 In addition, different imaging techniques have attempted to better identify the substrate underlying sudden cardiac death, specifically advanced echocardiographic and CMR techniques, as well as nuclear imaging with PET and SPECT. The different imaging techniques reflect different aspects of the LV substrate underlying the lethal ventricular arrhythmias; the anatomical substrate is probably the presence of central homogenous scar tissue (secondary to myocardial infarction), with a peripheral, heterogeneous border zone with fibrosis, viable but jeopardized myocardium and normal tissue.…”

Section: What Is the Problem?mentioning

confidence: 99%

Clinical utility of cardiac innervation imaging in patients with heart failure

Bax

2017

Journal of Nuclear Cardiology

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“…The most common risk factor for the development of ventricular tachyarrhythmias is coronary artery disease, in more than 80% of affected patients [6]. Furthermore, the presence of atrial fibrillation (AF) has recently been shown to increase the risk of ventricular tachyarrhythmias and SCD [7-9].…”

Section: Introductionmentioning

confidence: 99%

Digitalis Therapy and Risk of Recurrent Ventricular Tachyarrhythmias and ICD Therapies in Atrial Fibrillation and Heart Failure

et al. 2019

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Objective: This study sought to assess the impact of treatment with digitalis on recurrences of ventricular tachyarrhythmias in implantable cardioverter defibrillator (ICD) recipients with atrial fibrillation (AF) and heart failure (HF). Background: The data regarding outcomes of digitalis therapy in ICD recipients are limited. Methods: A large retrospective registry was used, including consecutive ICD recipients with episodes of ventricular tachyarrhythmia between 2002 and 2016. Patients treated with digitalis were compared to patients without digitalis treatment. The primary prognostic outcome was first recurrence of ventricular tachyarrhythmia at 5 years. Kaplan-Meier and multivariable Cox regression analyses were applied. Results: A total of 394 ICD recipients with AF and/or HF was included (26% with digitalis treatment and 74% without). Digitalis treatment was associated with decreased freedom from recurrent ventricular tachyarrhythmias (HR = 1.423; 95% CI 1.047–1.934; p = 0.023). Accordingly, digitalis treatment was associated with decreased freedom from appropriate ICD therapies (HR = 1.622; 95% CI 1.166–2.256; p = 0.004) and, moreover, higher rates of rehospitalization (38 vs. 21%; p = 0.001) and all-cause mortality (33 vs. 20%; p = 0.011). Conclusion: Among ICD recipients suffering from AF and HF, treatment with digitalis was associated with increased rates of recurrent ventricular tachyarrhythmias and ICD therapies. However, the endpoints may also have been driven by interactions between digitalis, AF, and HF.

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Mechanisms of sudden cardiac death

Cited by 31 publications

References 57 publications

Myocardial bridge-related coronary heart disease: Independent influencing factors and their predicting value

Myocardial bridge-related coronary heart disease: Independent influencing factors and their predicting value

Clinical utility of cardiac innervation imaging in patients with heart failure

Digitalis Therapy and Risk of Recurrent Ventricular Tachyarrhythmias and ICD Therapies in Atrial Fibrillation and Heart Failure

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