2000
DOI: 10.1038/sj.bjp.0703191
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Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells by andrographolide

Abstract: 1 Andrographolide, an active component found in leaves of Andrographis paniculata, has been reported to exhibit nitric oxide (NO) inhibitory property in endotoxin-stimulated macrophages, however, the detailed mechanisms remain unclear. In the present study we investigated the e ect of andrographolide on the expression of inducible NO synthase (iNOS) mRNA, protein, and enzyme activity in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS) plus interferon-g (IFN-g). 2 RAW 264.7 cells stimulated with L… Show more

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Cited by 185 publications
(120 citation statements)
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“…68) An anti-inflammatory benefit of andrographolide by reduction of inducible nitric oxide synthase (iNOS) protein expression through prevention of the de novo protein synthesis and decreasing the protein stability via a post-transcriptional mechanism has been inferred. [7][8][9] Furthermore, andrographolide exerted anti-inflammatory effects by inhibiting nuclear factor (NF)-κB binding to DNA, and thus reducing the expression of proinflammatory proteins, such as cyclooxygenase-2 (COX-2). 69) Another study showed weak antiinflammatory effects of andrographolide compared to other diterpenoid constituents in the plant, 4) in which the anti-inflammatory effect probably worked by a mechanism that involves secreted material from adrenal glands, since such effects disappeared in adrenalectomized animals.…”
Section: Anti-inflammatory Activitymentioning
confidence: 99%
See 1 more Smart Citation
“…68) An anti-inflammatory benefit of andrographolide by reduction of inducible nitric oxide synthase (iNOS) protein expression through prevention of the de novo protein synthesis and decreasing the protein stability via a post-transcriptional mechanism has been inferred. [7][8][9] Furthermore, andrographolide exerted anti-inflammatory effects by inhibiting nuclear factor (NF)-κB binding to DNA, and thus reducing the expression of proinflammatory proteins, such as cyclooxygenase-2 (COX-2). 69) Another study showed weak antiinflammatory effects of andrographolide compared to other diterpenoid constituents in the plant, 4) in which the anti-inflammatory effect probably worked by a mechanism that involves secreted material from adrenal glands, since such effects disappeared in adrenalectomized animals.…”
Section: Anti-inflammatory Activitymentioning
confidence: 99%
“…5) In Thailand, this plant was selected by the Ministry of Public Health as one of the medicinal plants to be included in "The National List of Essential Drugs A.D. 1999" (List of Herbal Medicinal Products). 6) Extensive research has revealed that Andrographis paniculata has a surprisingly broad range of pharmacological effects and some of them are extremely beneficial, such as antiinflammatory, [7][8][9][10][11] antidiarrhoeal, 12,13) antiviral, 14) anti-malarial, 15,16) hepatoprotective, [17][18][19][20][21][22][23][24][25][26][27][28][29] cardiovascular, 30,31) anticancer, [32][33][34][35][36][37][38][39] and immunostimulatory [40][41][42][43][44] activities. On the other hand, male reproductive toxicity 45) and cytotoxicity 46) of this plant have been reported as well.…”
Section: Introductionmentioning
confidence: 99%
“…The antioxidant activity is reported for 5 compounds from H.zeylanica (Huang et al, 2003), 2 compounds from P. papuana (Susilawati et al, 2011(Susilawati et al, & 2012, 3 compounds from P. guajava (Tachakittirungrod et al, 2007), 7 compounds from Rhizophora sp (Takara et al, 2008), 1 compound from Swietenia sp (Falah et al, 2008), and 2 compounds from Talinum sp (Kinoshita et al, 2007). Two antibacterial compounds were characterized from G.macrophyllus (Humeirah et al, 2010), and anti-inflammatory compounds from 4 plants species, 1 compound from A.paniculata (Chiou et al, 2000), 2 compounds from T. catappa (Fan et al, 2004), 1 compound from T. tuberculata (Yokozawa et al, 2004), and 6 compounds from Xylocarpus granatum .…”
Section: Compounds Isolated From Indonesian Medicinal Plants For Use mentioning
confidence: 99%
“…It is particularly known for its extremely bitter properties and is used traditionally as a remedy against common cold, fever, inflammation, etc. The main bioactive chemical constituent, andrographolide, has been reported to have various pharmacological activities including anti-inflammatory via different mechanisms (Chiou et al, 2000;Shen et al, 2002;Satyanarayana et al, 2004;Xia et al, 2004;Abu-Ghefreh et al, 2009;Levita, et al, 2010), anticancer and antitumour (Satyanarayana et al, 2004;Shen et al, 2009). Besides its function for medical purposes, sambiloto herbs infusion is frequently used to maintain health.…”
Section: Introductionmentioning
confidence: 99%