Mechanisms of Synaptic Transmission in the Cuneate Nucleus

Andersen, P.; Eccles, John C.; Oshima, Tomokazu; Schmidt, Robert F.

doi:10.1152/jn.1964.27.6.1096

Cited by 186 publications

(79 citation statements)

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“…This observation appears to be at variance with that reported by Marshall (1941) and Andersen, Eccles, Oshima & Schmidt (1964). It is possible that this difference could by due to either the species, the type of anaesthesia or the depth of anaesthesia used.…”

Section: Discussioncontrasting

confidence: 38%

Cortical responses to paired stimuli applied peripherally and at sites along the somato‐sensory pathway

Angel¹

1967

The Journal of Physiology

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SUMMARY1. Experiments have been performed on animals anaesthetized with various anaesthetics to determine the responsiveness of the cortex to the second of a pair of identical stimuli applied at three sites along the sensory pathway, i.e. to the periphery, the medial lemniscus and to thalamocortical fibres.2. It has been found that in deeply anaesthetized animals the mass response recorded from the cerebral cortex to the second of a pair of peripheral or lemniscal stimuli became reduced in size if the interval between the stimuli was 30-500 msec. If the interval was less than 30 msec for peripheral stimuli or between 10 and 30 msec for lemniscal stimuli responses were not obtained to the second stimulus. This was found to be a basic pattern which could be modified in animals less deeply anaesthetized. In these animals, periods of relatively increased responsiveness were seen after peripheral stimulation.3. The post-synaptic responses recorded from the ventrobasal thalamus showed the same behaviour to the second of a pair of peripheral stimuli as did the cortex both as regards size and latency of the responses.4. The post-synaptic responses recorded from the cuneate nucleus rarely showed any reduction in size unless the separation between the stimuli was 10 msec or less; even at intervals as low as 3 msec there was no increase in the latency of the response.5. When a pair of stimuli were applied to thalamocortical fibres, a different pattern of cortical responsiveness was found. At the time the cortical response to stimulation at pre-thalamic sites was reduced or abolished, the response to stimulation at post-thalamic sites was unaltered or increased in size.

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Section: Discussioncontrasting

confidence: 38%

Cortical responses to paired stimuli applied peripherally and at sites along the somato‐sensory pathway

Angel¹

1967

The Journal of Physiology

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“…Part of the gating effect of contraction could be peripheral, 9 because contraction evokes afferent volleys that travel in both cutaneous and muscular nerves and can alter other sensory-evoked activity in dorsal column nuclei. [22][23][24][25] Attenuation of the initial positive-negative components of the cerebral SEP in our experiments during muscle contraction was 36%, similar to the 20% found by Ghez and Pisa 7 in cats during movement. The possible perceptual consequences of such attenuation was addressed by Coquery,6 who found in humans a decrease in the perception of electric cuta-neous stimulation before and during voluntary movement.…”

Section: Effects Of Gastrocne Mius-soleus Muscle Contractionsupporting

confidence: 90%

Vibration and muscle contraction affect somatosensory evoked potentials

Cohen¹,

Starr²

1985

Neurology

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Article abstract-We recorded potentials evoked by specific somatosensory stimuli over peripheral nerve, spinal cord, and cerebral cortex. Vibration attenuated spinal and cerebral potentials evoked by mixed nerve and muscle spindle stimulation; in one subject that was tested, there was no effect on cutaneous input. Presynaptic inhibition ofla input in the spinal cord and muscle spindle receptor occupancy are probably the responsible mechanisms. In contrast, muscle contraction attenuated cerebral potentials to both cutaneous and muscle spindle afferent volleys; central mechanisms modulating neurons in the dorsal columns nuclei, thalamus, or cerebral cortex are probably responsible.

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“…Whereas the interneurons within the medial cuneate nucleus appear to be inhibitory (Andersen et al, 1964b;Barbaresi et al, 1986;Berkley et al, 1986;Rustioni and Weinberg, 1989;Heino and Westman, 1991), this work demonstrated that excitatory interneurons are present at the rvCN. The suppression of mvCN activity by GABA and glycine applied together was more effective Figure 12.…”

Section: Gaba and Glycine Constrained Mvcn Responses To A Single Artimentioning

confidence: 56%

Processing Afferent Proprioceptive Information at the Main Cuneate Nucleus of Anesthetized Cats

Leiras¹,

Velo²,

Martín-Cora³

et al. 2010

J. Neurosci.

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Medial lemniscal activity decreases before and during movement, suggesting prethalamic modulation, but the underlying mechanisms are largely unknown. Here we studied the mechanisms underlying proprioceptive transmission at the midventral cuneate nucleus (mvCN) of anesthetized cats using standard extracellular recordings combined with electrical stimulation and microiontophoresis. Dual simultaneous recordings from mvCN and rostroventral cuneate (rvCN) proprioceptive neurons demonstrated that microstimulation through the rvCN recording electrode induced dual effects on mvCN projection cells: potentiation when both neurons had excitatory receptive fields in muscles acting at the same joint, and inhibition when rvCN and mvCN cells had receptive fields located in different joints. GABA and/or glycine consistently abolished mvCN spontaneous and sensory-evoked activity, an effect reversed by bicuculline and strychnine, respectively; and immunohistochemistry data revealed that cells possessing strychnine-sensitive glycine receptors were uniformly distributed throughout the cuneate nucleus. It was also found that proprioceptive mvCN projection cells sent ipsilateral collaterals to the nucleus reticularis gigantocellularis and the mesencephalic locomotor region, and had slower antidromic conduction speeds than cutaneous fibers from the more dorsally located cluster region.The data suggest that (1) the rvCN-mvCM network is functionally related to joints rather than to single muscles producing an overall potentiation of proprioceptive feedback from a moving forelimb joint while inhibiting, through GABAergic and glycinergic interneurons, deep muscular feedback from other forelimb joints; and (2) mvCN projection cells collateralizing to or through the ipsilateral reticular formation allow for bilateral spreading of ascending proprioceptive feedback information.

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Mechanisms of Synaptic Transmission in the Cuneate Nucleus

Cited by 186 publications

References 0 publications

Cortical responses to paired stimuli applied peripherally and at sites along the somato‐sensory pathway

Cortical responses to paired stimuli applied peripherally and at sites along the somato‐sensory pathway

Vibration and muscle contraction affect somatosensory evoked potentials

Processing Afferent Proprioceptive Information at the Main Cuneate Nucleus of Anesthetized Cats

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