Mechanisms of the Cardiovascular Effects of Neurotensin*

Emerging role of neurotensin in regulation of the cardiovascular system

“…In support of this notion, NT administration is associated with heart rate acceleration in rat (Bachelard et al, 1992;Chahl and Walker, 1981;Rioux et al, 1982a, 1982b), guinea-pig (Bachelard et al, 1985Kerouac et al, 1981;Nisato et al, 1994;Rioux et al, 1982a;Rioux and Lemieux, 1992), and cat (Pokrovsky and Osadchiy, 1995).…”

“…At nanomolar concentrations, it elicits marked hypotensive effects upon intravenous infusion in rat (Chahl and Walker, 1981;Di Paola and Richelson, 1990;Quirion et al, 1980d;Rioux et al, 1982a) and dog (Bauer et al, 1995;Ertl et al, 1993). In contrast, NT produces dose-dependent increase in blood pressure in guinea-pig (Bachelard et al, 1987;Kerouac et al, 1981;Nisato et al, 1994;Rioux et al, 1982a;Rioux and Lemieux, 1992).…”

“…Heart rate acceleration induced by NT upon systemic administration (Kerouac et al, 1981;Rioux et al, 1982a) or following its infusion in isolated, perfused guinea-pig hearts (Bachelard et al, 1985) is not abolished by ganglion blocking agents or antagonists of β-adrenoreceptors, H 2 -histamine and 5-hydroxytryptamine receptors, thus indicating a direct effect of NT on sinoatrial node. Alternatively, NT-induced positive chronotropic responses could be mediated via stimulation of substance P and/or calcitonin generelated peptide release from cardiac primary sensory neurons (Rioux et al, 1988).…”

“…At nanomolar concentrations, it elicits marked hypotensive effects upon intravenous infusion in rat (Chahl and Walker, 1981;Di Paola and Richelson, 1990;Quirion et al, 1980d;Rioux et al, 1982a) and dog (Bauer et al, 1995;Ertl et al, 1993). In contrast, NT produces dose-dependent increase in blood pressure in guinea-pig (Bachelard et al, 1987;Kerouac et al, 1981;Nisato et al, 1994;Rioux et al, 1982a;Rioux and Lemieux, 1992). In many studies, NT has also been reported to evoke biphasic or triphasic variations of blood pressure (Gully et al, 1996;Kaczynska and Szereda-Przestaszewska 2012;Kerouac et al, 1981Kerouac et al, , 1983Nisato et al, 1994;Oishi et al, 1981;Onarheim et al, 1982;Quirion et al, 1980d;Rioux et al, 1982aRioux et al, , 1982b.…”

Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor.

“…In addition, neurotensin exerts potent hypothermic and analgesic effects when injected into the central nervous system (10,11). In the periphery, it acts as a paracrine and endocrine modulator of digestive functions (4,12) and produces numerous effects on the cardiovascular system of mammals (13).…”