2018
DOI: 10.1016/j.hlc.2017.07.002
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Mechanisms of the Improvement in Peak VO2 With Exercise Training in Heart Failure With Reduced or Preserved Ejection Fraction

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Cited by 53 publications
(42 citation statements)
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References 73 publications
(138 reference statements)
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“…Recently, Billebeau et al found that of all the biomarkers they tested, for predicting change in exercise capacity, MR-proADM best correlated with VO 2peak 22. Given that adrenomedullin originates not only from the heart but also from multiple organs, tissues and blood vessels78 and that the mechanisms associated with improved exercise capacity in HF involve cardiac, vascular and skeletal muscle adaptations,79 a relationship between MR-proADM and improved exercise capacity makes sense.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, Billebeau et al found that of all the biomarkers they tested, for predicting change in exercise capacity, MR-proADM best correlated with VO 2peak 22. Given that adrenomedullin originates not only from the heart but also from multiple organs, tissues and blood vessels78 and that the mechanisms associated with improved exercise capacity in HF involve cardiac, vascular and skeletal muscle adaptations,79 a relationship between MR-proADM and improved exercise capacity makes sense.…”
Section: Discussionmentioning
confidence: 99%
“…Following the Fick principle, i.e., VO 2 = cardiac output × arteriovenous O 2 difference, improvement in peak VO 2 is caused by a cardiac factor (cardiac output), a noncardiac factor (peripheral O 2 extraction), or both. In HFrEF patients, both cardiac and noncardiac factors are improved by exercise (Tucker et al., 2018). In HFpEF, several mechanisms have been proposed, investigated, and then refuted.…”
Section: Effects Of Exercise Training In Heart Failure With Preservedmentioning
confidence: 99%
“…Lewinter et al (5) confirmed these previous results, demonstrating significant improvements in exercise capacity and hospitalizations but not in mortality. Moreover, the results of studies examining improvements in peak VO 2 after an exercise training program vary widely (6,7).…”
mentioning
confidence: 99%