Mechanisms of TonB-catalyzed iron transport through the enteric bacterial cell envelope

Klebba, Phillip E.; Rutz, Jeanette M.; Li, Jun; Murphy, Christian

doi:10.1007/bf00770247

Cited by 79 publications

(3 citation statements)

References 45 publications

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“…The energy is most probably provided via interactions with TonB, which is essential for the function of FepA (Wang and Newton, 1969). Although TonB is located in the bacterial plasma membrane, the bulk of the protein extends into the periplasm and is able to contact FepA in the outer membrane (Klebba et al ., 1993). This contact somehow transduces the energy status of the plasma membrane, inducing the conformational changes seen in FepA.…”

Section: Introductionmentioning

confidence: 99%

NEW EMBO MEMBERS' REVIEW: Ion channels in the outer membranes of chloroplasts and mitochondria: open doors or regulated gates?

Bölter

Soll

2001

The EMBO Journal

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Section: Introductionmentioning

confidence: 99%

NEW EMBO MEMBERS' REVIEW: Ion channels in the outer membranes of chloroplasts and mitochondria: open doors or regulated gates?

Bölter

Soll

2001

The EMBO Journal

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“…TonB is an inner membrane protein facilitating the energy-dependent transport of several molecules [ 44 , 45 ]. Among these are vitamin B12 and iron-siderophore complexes, which were shown to transit through different tonB -dependent receptors (TBDRs) [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Commensal E. coli limits Salmonella gut invasion during inflammation by producing toxin-bound siderophores in a tonB-dependent manner

Cherrak,

Salazar,

Yilmaz

et al. 2024

PLoS Biol

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The gastrointestinal tract is densely colonized by a polymicrobial community known as the microbiota which serves as primary line of defence against pathogen invasion. The microbiota can limit gut-luminal pathogen growth at different stages of infection. This can be traced to specific commensal strains exhibiting direct or indirect protective functions. Although these mechanisms hold the potential to develop new approaches to combat enteric pathogens, they remain far from being completely described. In this study, we investigated how a mouse commensal Escherichia coli can outcompete Salmonella enterica serovar Typhimurium (S. Tm). Using a salmonellosis mouse model, we found that the commensal E. coli 8178 strain relies on a trojan horse trap strategy to limit S. Tm expansion in the inflamed gut. Combining mutants and reporter tools, we demonstrated that inflammation triggers the expression of the E. coli 8178 antimicrobial microcin H47 toxin which, when fused to salmochelin siderophores, can specifically alter S. Tm growth. This protective function was compromised upon disruption of the E. coli 8178 tonB-dependent catecholate siderophore uptake system, highlighting a previously unappreciated crosstalk between iron intake and microcin H47 activity. By identifying the genetic determinants mediating S. Tm competition, our work not only provides a better mechanistic understanding of the protective function displayed by members of the gut microbiota but also further expands the general contribution of microcins in bacterial antagonistic relationships. Ultimately, such insights can open new avenues for developing microbiota-based approaches to better control intestinal infections.

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“…Both TDTs TbpA and LbpA are capable of binding to, and extracting iron from, their human ligand in the absence of their respective lipoprotein partner; however, the TDT HpuB requires the lipoprotein HpuA to utilize the iron or heme from Hb and Hb-Hp complexes (Lewis et al, 1997;Lewis et al, 1998;Rohde et al, 2002;Rohde and Dyer, 2004). HpuB (85 kDa) is the outer-membrane receptor (Postle, 1993;Klebba et al, 1993) and HpuA (35 kDa) is the lipoprotein partner (Lewis et al, 1997;Rohde et al, 2002;Anzaldi and Skaar, 2010). In N. meningitidis, HpuAB binds to Hb, Hb-Hp, and apohaptoglobin .…”

Section: Iron Requirements and Sequestration Proteins In The Human Hostmentioning

confidence: 99%

Metal homeostasis in microbial physiology and virulence

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Mechanisms of TonB-catalyzed iron transport through the enteric bacterial cell envelope

Cited by 79 publications

References 45 publications

NEW EMBO MEMBERS' REVIEW: Ion channels in the outer membranes of chloroplasts and mitochondria: open doors or regulated gates?

NEW EMBO MEMBERS' REVIEW: Ion channels in the outer membranes of chloroplasts and mitochondria: open doors or regulated gates?

Commensal E. coli limits Salmonella gut invasion during inflammation by producing toxin-bound siderophores in a tonB-dependent manner

Metal homeostasis in microbial physiology and virulence

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