Mechanisms of toxic cardiomyopathy

Abstract

Background: Dilated cardiomyopathy is a frequent disease responsible for 40-50% of cases of heart failure. Idiopathic cardiomyopathy is a primary disorder often related to familial/genetic predisposition. Before the diagnosis of idiopathic cardiomyopathy is made, clinicians must not only rule out viral and immune causes, but also toxic causes such as drugs, environmental agents, illicit substances and natural toxins. Objective: The objective of this review is to present recent data on the mechanisms underlying toxic cardiomyopathy. Methods: The US National Library of Medicine Pubmed database was searched from 1980 to December 2017 utilizing the combinations of the search terms "toxic cardiomyopathy", "drugs", "anticancer drugs", "azidothymidine", "rosiglitazone", "carbon monoxide", "alcohol", "illicit drugs", "cocaine", "metamfetamine", "metals", "venom". A total of 339 articles were screened and papers that dealt with the pathophysiology of toxic cardiomyopathy, either in animal models or in clinical practice were selected, with preference being given to more recently published papers, which left 92 articles. Anticancer drugs: The mechanisms of anthracycline-induced cardiotoxicity are primarily related to their mechanisms of action as anticancer drugs, mainly the inhibition of topoisomerase II b and DNA cleavage. Additional metabolic or oxidative stress factors may play a part, together with interference with iron metabolism. The more recent drugs, trastuzumab and imatinib, also influence stress pathways. Antiretroviral agents: Azidothymidine is cardiotoxic as a result of mitochondrial toxicity. In addition to energy depletion, azidothymidine also increases the production of mitochondrial reactive oxygen species (ROS). Antidiabetic drugs: The cardiotoxicity of thiazolidinedione antidiabetic drugs is still under investigation, though interference with mitochondrial respiration or oxidative stress is suspected. Cocaine: Among the multiple mechanisms involved in cocaine-related cardiotoxicity, excessive sympathetic stimulation with increased myocardial oxygen consumption is well documented in the acute form of left ventricular dysfunction. As for cocaine-related cardiomyopathy, the role of apoptosis and ROS is under investigation. Ethanol: The aetiology of ethanol-related cardiotoxicity is multifactorial, with individual susceptibility being important. It involves apoptosis, alterations of the excitation-contraction coupling in cardiac myocytes, structural and functional alterations of the mitochondria and sarcoplasmic reticulum, changes in cytosolic calcium flows, changes in calcium sensitivity of myofilaments, alterations of mitochondrial oxidation, deregulation of protein synthesis, decrease of contractile proteins and disproportion between the different types of myofibrils, changes in the regulation of myosin ATPase, up-regulation of the L-type calcium channels, increase of oxidative stress, and induction of ANP and p21 mRNA expression in ventricular myocardium. Metamfetamines: Catecholamine-mediated toxicity i...

Dilated cardiomyopathy

“…Studies in animals have demonstrated that acute and chronic ethanol administration impairs cardiac contractility 112 and decreases the contractile protein α-myosin heavy chain 110 . The metabolite of alcohol, acetaldehyde, can alter cellular calcium, magnesium and phosphate homeo stasis and impair mitochondrial respiration, for example 113 . Damage to the myocardium from alcohol also recruits inflammatory cells to the heart 114 .…”

p53‐Mediated Activities in NS‐5 Neural Stem Cells: Effects of Ethanol

“…The only transcript specifically affected by EtOH is Pak1 (p21‐activated kinase 1), a critical regulator of p21, a key player in cell cycle exit (Seoane et al., ; Siegenthaler and Miller, ), and target of EtOH (e.g., Hantson, ; Haycock, ). It is noteworthy that, like TGFβ1 receptor (Heldin and Moustakas, ), Pak1 is a serine‐threonine kinase (Bokoch et al., ; Galisteo et al., ).…”

Miocardiopatía dilatada: ¿cuándo y cómo proceder a la investigación etiológica?

“…La miocardiopatía alcohólica es a menudo subdiagnosticada, ya que algunos estudios muestran un prevalencia de hasta el 20% de las MCD. El alcohol causa la disfunción sistólica del VI de una manera aparentemente relacionada con la dosis y algunos estudios sugieren reversibilidad tras la abstención (4) . En el caso de las drogas de quimioterapia existen tres tipos diferentes.…”

“…La medición de parámetros de función diastólica como llenado ventricular, tamaño auricular, relación E/e' como expresión de presiones de llenado y presión sistólica pulmonar no debe ser olvidada. La mayor disponibilidad en los equipos de tecnología de Doppler tisular así como speckle tracking facilita la caracterización tisular no invasiva (2,4) .…”