Mechanisms of ventilator-induced lung injury in premature infants

Attar, Mohammad A.; Donn, Steven M.

doi:10.1053/siny.2002.0129

Cited by 189 publications

(115 citation statements)

References 57 publications

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“…Extrapolating immediate improvement in compliance from animal studies 3,4 suggests the potential for rapid increase in tidal volume delivery and lung overdistention and injury following surfactant administration if the ventilator is used in a pressure-targeted modality and pressure is not promptly decreased. 6 However, such extrapolation from in vitro studies and animal models has to be carried out with caution, since factors other than surface properties are important for the in vivo responses to surfactant treatment. 7 We conducted this randomized trial to further define the immediate changes in pulmonary compliance in infants with RDS treated with natural surfactants differing in their SP-B content.…”

Section: Introductionmentioning

confidence: 99%

Immediate Changes in Lung Compliance Following Natural Surfactant Administration in Premature Infants with Respiratory Distress Syndrome: a Controlled Trial

et al. 2004

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Section: Introductionmentioning

confidence: 99%

Immediate Changes in Lung Compliance Following Natural Surfactant Administration in Premature Infants with Respiratory Distress Syndrome: a Controlled Trial

et al. 2004

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“…[20][21][22] El efecto de la hiperoxia a través de radicales libres en los prematuros se ve favorecido por una disminución de mecanismos antioxidantes en este grupo de niños. 3,20,21 El estudio aleatorizado SUPPORT comparó dos rangos de objetivos de saturación de oxígeno en prematuros menores de 28 semanas durante toda su internación.…”

Section: Discussionunclassified

“…[3][4][5][6][7][8][9][10]24 El exceso de volumen corriente en cada ciclo conduce al denominado "volutrauma", caracterizado por una sobredistensión de la membrana alveolocapilar, desarrollo de una reacción inflamatoria, edema intersticial e inactivación de surfactante. 22 En nuestro estudio, tanto la utilización de oxígeno como el requerimiento de ventilación asistida y surfactante pulmonar (como expresión de gravedad del síndrome de dificultad respiratoria inicial) se asociaron a DBP en el análisis univariado.…”

Section: Discussionunclassified

Displasia broncopulmonar: incidencia y factores de riesgo

et al. 2017

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“…[20][21][22] The effect of hyperoxia on free radicals in preterm infants is favored by a reduction in antioxidative mechanisms in this group of infants. 3,20,21 SUPPORT, a randomized study, compared two target ranges of oxygen saturation in preterm infants younger than 28 weeks throughout their hospitalization.…”

Section: Discussionmentioning

confidence: 99%

Bronchopulmonary dysplasia: incidence and risk factors

et al. 2017

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Introduction. Bronchopulmonary dysplasia is the most common chronic pulmonary sequela among very low birth weight infants. The objective of this study was to estimate its incidence in our Neonatal Unit over the past 5 years and analyze associated risk factors. Population and methods. An observational and analytical study was conducted in a retrospective cohort, using data obtained from a prospective database of infants born at Hospital Italiano de Buenos Aires with a birth weight of less than 1500 grams between January 2010 and December 2014. The incidence of bronchopulmonary dysplasia and its association with several secondary outcome measures were studied. Results. Two hundred and forty-five patients were included. The incidence of moderate/ severe bronchopulmonary dysplasia was 22%, and it was associated with a younger gestational age and lower birth weight. A significant association was observed with surfactant use, mechanical ventilation requirement, and length of mechanical ventilation. Patients with moderate/severe bronchopulmonary dysplasia had a higher incidence of patent ductus arteriosus and late-onset sepsis. A lower birth weight (adjusted odds ratio [aOR]: 0.99, 95% confidence interval [CI]: 0.991-0.997, p< 0.001) and the length of mechanical ventilation (aOR: 1.08, 95% CI: 1.01-1.15, p < 0.01) remained associated following adjustment for other outcome measures. In addition, an association was observed among patients with intrauterine growth restriction born at less than 32 weeks of gestational age (OR: 4.71, 95% CI: 1.68-13.2). Conclusions. The incidence of bronchopulmonary dysplasia in our unit was associated with a lower birth weight and the length of mechanical ventilation. Among infants born at less than 32 weeks of gestation, intrauterine growth restriction accounted for an additional risk.

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Mechanisms of ventilator-induced lung injury in premature infants

Cited by 189 publications

References 57 publications

Immediate Changes in Lung Compliance Following Natural Surfactant Administration in Premature Infants with Respiratory Distress Syndrome: a Controlled Trial

Immediate Changes in Lung Compliance Following Natural Surfactant Administration in Premature Infants with Respiratory Distress Syndrome: a Controlled Trial

Displasia broncopulmonar: incidencia y factores de riesgo

Bronchopulmonary dysplasia: incidence and risk factors

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