Mechanisms of ventricular arrhythmias in cardiac failure and hypertrophy

Pye, Maurice; Cobbe, Stuart M.

doi:10.1093/cvr/26.8.740

Cited by 137 publications

(61 citation statements)

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“…[4][5][6][7][8] The long term significance of increased QT dispersion in hypertensive patients and its relationship to sudden cardiac death has not been determined previously although QT dispersion in hypertension has been studied on many occasions. [18][19][20][21][22][23] However the relationship between increased QT dispersion, LVH and ventricular arrhythmias as determined by 24-h ambulatory electrocardiographic recordings over long-term followup has not been studied previously in completely untreated patients.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, increased QT dispersion in the 12-lead surface electrocardiogram has been associated with ventricular arrhythmias and sudden cardiac death in a variety of cardiac diseases. [4][5][6][7][8] The relationships between QT dispersion, LVH, complex ventricular arrhythmias and sudden cardiac death over long-term follow-up in hypertensive patients has not been studied previously. The aim of this study therefore was to examine the prognostic significance of these parameters in previously untreated patients.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of sudden cardiac death in never previously treated patients with essential hypertension: long-term follow-up

Saadeh

Jones

2001

J Hum Hypertens

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Increased QT dispersion has been associated with ventricular arrhythmia and sudden death in a variety of cardiac disorders. Left ventricular hypertrophy (LVH) has also been associated with increased incidence of sudden cardiac death in patients with essential hypertension. Furthermore, patients with essential hypertension, particularly those with LVH, are more likely to develop ventricular arrhythmias than are the normal population. The relationship between LVH, QT dispersion, complex ventricular arrhythmia and sudden cardiac death in previously untreated patients over long-term follow-up in hypertension has not been reported before and is the purpose of this study. Fifty-nine adult subjects with essential hypertension, who had never been previously on antihypertensive treatment were followed up for a total of 119.2 ؎ 26.2 months. QTc (corrected QT), blood pressure, electrocardiograms, and 24-h Holter ECG recordings were performed in all patients at the time of entry to the study. Ventricular arrhythmias were classi-

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predictors of sudden cardiac death in never previously treated patients with essential hypertension: long-term follow-up

Saadeh

Jones

2001

J Hum Hypertens

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“…18,19) Indeed, the direction of injury flow is opposite between LCB and RCB ischemia. The amount of injury flow may also be larger in LCB ischemia than in RCB ischemia.…”

Section: Mechanisms Of Increased Vulnerability To Ischemia-or Reperfumentioning

confidence: 99%

“…These geometric factors have been studied and stressed. 18) We designed this study to determine the role of interface area and volume of ischemic myocardium. It should be noted that this is the first study negating the "flow injury current theory" in LV hypertrophy.…”

Section: Mechanisms Of Increased Vulnerability To Ischemia-or Reperfumentioning

confidence: 99%

Susceptibility to Ischemia and Reperfusion Arrhythmias in Myocardial Hypertrophy Due to Flow of Injury Current?

Shimada

Avkiran

2003

Jpn Heart J

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SUMMARYLeft ventricle (LV) hypertrophy is associated with an increased risk of sudden death, which may be due in part to a greater vulnerability to severe ventricular arrhythmias. Our objectives were to determine (i) whether pressure overload-induced LV hypertrophy increases susceptibility to ischemia-and/or reperfusion-induced ventricular fibrillation (VF), and (ii) whether any increased susceptibility is mediated by changes intrinsic to the hypertrophied myocardium. LV pressure overload was induced in rats by abdominal aortic constriction (AC), while controls received sham-operations (SH). Three weeks after the operation, LV weight was 44 ± 3% greater in AC rats than in SH rats although right ventricle (RV) weights were similar. At this time, isolated hearts (n = 12/group) were subjected to dual coronary perfusion. After 15 minutes of aerobic perfusion, either the left or right coronary bed (supplying predominantly LV or RV tissue, respectively) was subjected to 7 minutes of zero-flow ischemia and either 5 minutes of reperfusion (reperfusion study) or 40 minutes of sustained ischemia (ischemia study). AC rats exhibited greater susceptibility than SH rats to both ischemia-and reperfusion-induced ventricular fibrillation, but only when the hypertrophied LV was subjected to ischemia. The increased susceptibility to arrhythmias was not entirely due to a larger ischemic zone, indicating that intrinsic changes within hypertrophied myocardium played a role in arrhythmogenesis. (Jpn Heart J 2003; 44: 989-1004)

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“…These alterations increase the tendency to the development of cardiovascular diseases and neuropathies, which represent one of the major causes of death of patients 1,2 . Alterations in carbohydrate and lipid metabolism as well as electrolytic changes in blood calcium and potassium may cause modifications in the cardiovascular structure and physiology which, in turn, lead to alterations in electrocardiographic recording 3,4 .…”

Section: Introductionmentioning

confidence: 99%

Os efeitos da metformina sobre a dispersão do intervalo QT e QTc de ratos diabéticos

Costa

Gonçalves

Áreas

et al. 2008

Arq. Bras. Cardiol.

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SummaryBackground: Several drugs can cause prolonged QT interval, as well as prolonged QT dispersion (QTd) in electrocardiographic (EKG) recordings. QTd may be a potentially sensitive marker of increased risk of cardiac arrhythmias and sudden cardiac death. Metformin is an effective antihyperglycemic agent used in the treatment of diabetes. However, studies have correlated dose-dependent effects of metformin on glycemia and cardiovascular risk markers.

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Mechanisms of ventricular arrhythmias in cardiac failure and hypertrophy

Cited by 137 publications

References 0 publications

Predictors of sudden cardiac death in never previously treated patients with essential hypertension: long-term follow-up

Predictors of sudden cardiac death in never previously treated patients with essential hypertension: long-term follow-up

Susceptibility to Ischemia and Reperfusion Arrhythmias in Myocardial Hypertrophy Due to Flow of Injury Current?

Os efeitos da metformina sobre a dispersão do intervalo QT e QTc de ratos diabéticos

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