Mechanisms of white mustard seed (Sinapis alba L.) volatile oils as transdermal penetration enhancers

Ruan, Shi Fa; Wang, Zhu Xian; Xiang, Shi Jian; Chen, Huo Ji; Shen, Qun; Liu, Li; Wu, Wen Feng; Cao, Si Wei; Wang, Zong Wei; Yang, Zhijun; Weng, Li Dong; Zhu, Hong; Qiang, Liu

doi:10.1016/j.fitote.2019.104195

Cited by 17 publications

(11 citation statements)

References 35 publications

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“…This result was consistent with previous reports. Usually, permeation enhancers improve the permeation of drug into the skin by disordering the arrangement of lipids and improving the lipid flexibility of SC [11,33]. Moreover, this process is dependent on the physicochemical properties of the enhancers rather than the amount of enhancers [34].…”

Section: Discussionmentioning

confidence: 99%

“…Song concluded that permeation enhancers that form hydrogen bonds, such as Span 80 (SP), weaken drug-adhesive interaction, facilitating the release of drug from adhesive [10]. On the other hand, permeation enhancers disrupt the skin lipid arrangement [11,12], change the keratin structure [13], enhance the miscibility of the skin [14], and increase drug partitioning into deeper skin layers [15] to improve the skin permeation of drugs. Plurol ® Oleique CC 497 (POCC) showed a preference for occupying sites where skin lipids had interacted with drugs with low PSA and polarizability due to the improved skin-POCC miscibility and stronger interactions [16].…”

Section: Introductionmentioning

confidence: 99%

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Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release and Permeation Enhancement from Carbomer Hydrogel

et al. 2022

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This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release and permeation from Carbomer 940 (CP) hydrogels with different enhancers, and evaluate the relationship between the quantitative enhancement efficacy and structures of the enhancers. An in vitro release study and an in vitro permeation experiment in solution and hydrogels using porcine skin were performed. We found that the Gla–CP hydrogel showed a higher drug release and skin retention amount than LicA–CP due to the higher solubility in medium and better miscibility with the skin of Gla than that of LicA. Enhancers with a higher molecular weight (MW) and lower polarizability showed a higher release enhancement effect (ERrelease) for both LicA and Gla. The Van der Waals forces in the drug–enhancers–CP system were negatively correlated with the drug release percent. Moreover, enhancers with a higher log P and polarizability displayed a higher retention enhancement effect in solution (ERsolution retention) for LicA and Gla. Enhancers decreased the whole intermolecular forces indrug–enhancers-skin system, which had a linear inhibitory effect on the drug retention. Moreover, C=O of ceramide acted asthe enhancement site for drug permeation. Consequently, Transcutol® P (TP) and propylene glycol (PG), seven enhancers showed a higher retention enhancement effect in hydrogel (ERhydrogel retention) for LicA and Gla. Taken together, the conclusions provide a strategy for reasonable utilization of enhancers and formulation optimization in topical hydrogel whitening.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release and Permeation Enhancement from Carbomer Hydrogel

et al. 2022

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“…Reports showed a peak urine concentration for a pyrrolidone metabolite product 10 h after dermal exposure to an aqueous dilution of 5-hydroxy-N-methyl-2-pyrrolidone [ 204 , 205 ]. However, pyrrolidones have failed to achieve clinical translation due to reported adverse effects [ 195 , 206 ].…”

Section: Vaccination Into the Dermal Compartment Without Needle Anmentioning

confidence: 99%

Vaccination into the Dermal Compartment: Techniques, Challenges, and Prospects

Hettinga

Carlisle

2020

Vaccines

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In 2019, an ‘influenza pandemic’ and ‘vaccine hesitancy’ were listed as two of the top 10 challenges to global health by the WHO. The skin is a unique vaccination site, due to its immune-rich milieu, which is evolutionarily primed to respond to challenge, and its ability to induce both humoral and cellular immunity. Vaccination into this dermal compartment offers a way of addressing both of the challenges presented by the WHO, as well as opening up avenues for novel vaccine formulation and dose-sparing strategies to enter the clinic. This review will provide an overview of the diverse range of vaccination techniques available to target the dermal compartment, as well as their current state, challenges, and prospects, and touch upon the formulations that have been developed to maximally benefit from these new techniques. These include needle and syringe techniques, microneedles, DNA tattooing, jet and ballistic delivery, and skin permeabilization techniques, including thermal ablation, chemical enhancers, ablation, electroporation, iontophoresis, and sonophoresis.

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“…It is grown originally in the Mediterranean Sea region and distributed worldwide [141]. White mustard is used in the treatment of deep abscess disease and numbness of the joints [142]. Sinapis alba L. oil (SVO) is a volatile essential oil extracted from this plant mechanically by cold pressing [141].…”

Section: White Mustard Seed (Sinapis Alba L) Volatile Oilmentioning

confidence: 99%

“…Sinapis alba L. oil (SVO) is a volatile essential oil extracted from this plant mechanically by cold pressing [141]. Ruan et al [142] reported that SVO was a more effective enhancer of both hyrophillic and lipophilic drugs such as 5-fluorouracil, osthole, and paeonol, compared to Azone.…”

Section: White Mustard Seed (Sinapis Alba L) Volatile Oilmentioning

confidence: 99%

Systematic Review on the Effectiveness of Essential and Carrier Oils as Skin Penetration Enhancers in Pharmaceutical Formulations

2022

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Oils, including essential oils and their constituents, are widely reported to have penetration enhancement activity and have been incorporated into a wide range of pharmaceutical formulations. This study sought to determine if there is an evidence base for the selection of appropriate oils for particular applications and compare their effectiveness across different formulation types. A systematic review of the data sources, consisting of Google Scholar, EMBASE, PubMed, Medline, and Scopus, was carried out and, following screening and quality assessment, 112 articles were included within the analysis. The research was classified according to the active pharmaceutical ingredient, dosage form, in vitro/in vivo study, carrier material(s), penetration enhancers as essential oils, and other chemical enhancers. The review identified four groups of oils used in the formulation of skin preparations; in order of popularity, these are terpene-type essential oils (63%), fatty acid-containing essential oils (29%) and, finally, 8% of essential oils comprising Vitamin E derivatives and miscellaneous essential oils. It was concluded that terpene essential oils may have benefits over the fatty acid-containing oils, and their incorporation into advanced pharmaceutical formulations such as nanoemulsions, microemulsions, vesicular systems, and transdermal patches makes them an attractive proposition to enhance drug permeation through the skin.

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Mechanisms of white mustard seed (Sinapis alba L.) volatile oils as transdermal penetration enhancers

Cited by 17 publications

References 35 publications

Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release and Permeation Enhancement from Carbomer Hydrogel

Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release and Permeation Enhancement from Carbomer Hydrogel

Vaccination into the Dermal Compartment: Techniques, Challenges, and Prospects

Systematic Review on the Effectiveness of Essential and Carrier Oils as Skin Penetration Enhancers in Pharmaceutical Formulations

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