Mechanisms Responsible for the Elevated Blood Pressure in the Cerebral Hypertensive Rabbit

Rothman, Sol

doi:10.1152/ajplegacy.1954.180.1.61

Cited by 10 publications

(2 citation statements)

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“…9 The variable effect of pentobarbital anesthesia on the hypertensions of dogs with bilateral constriction of the carotid sinus area contrasts with the reduction of cerebral hyper-CRANDALL, McCROREY, SUKOWSKI AND WAKERLIX 091 tension in rabbits to normotension. 10 Pentobarbital anesthesia did not differentiate between carotid sinus area hypertension and buffer nerve hypertension in dogs.…”

Section: Discussionmentioning

confidence: 92%

Pathogenesis of Experimental Hypertension Produced by Carotid Sinus Area Constriction in Dogs

Crandall

Mccrorey

Sukowski³

et al. 1957

Circulation Research

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Section: Discussionmentioning

confidence: 92%

Pathogenesis of Experimental Hypertension Produced by Carotid Sinus Area Constriction in Dogs

Crandall

Mccrorey

Sukowski³

et al. 1957

Circulation Research

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“…Rothman, 7 however, found that cerebral hypertensive rabbits showed a reduced response to epinephrine and norepinephrine, which was attributed to a dose-response phenomenon due to increased release of norepinephrine at sympathetic endings. Brown and Maegraith 8 found that renal hypertensive rabbits showed increased pressor responses to tyramine, epinephrine, and vasopressin.…”

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confidence: 99%

Observations on the Responses of Rats with Spontaneous Hypertension and Control Rats to Pressor Drugs and to Hexamethonium

Phelan

Eryetishir

Smirk

1962

Circulation Research

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• A difficulty in studying the pathogenesis of essential hypertension is that spontaneous hypertension is not frequent in experimental animals. Most experimenters have used animals in which hypertension has been induced, usually by the production of renal ischemia. As essential hypertension in man is inheritable, an attempt was made to develop a spontaneous hypertension by selective breeding from rats with overaverage blood pressures. Eventually a strain of Wistar rats with overaverage blood pressures was obtained by Smirk and Hall 1 ; about 25 per cent of buck rats had tail blood pressures exceeding 140 mm. Hg and a few were above 160 mm. Hg. Since this article was published, the colony has improved and over 50 per cent of buck rats have systolic blood pressures exceeding 150 mm. Hg.We are unaware of any long series of experiments on animals with spontaneous hypertension, although Alexander et al.2 found the response to the cold pressor test was increased in the families of rabbits with spontaneous hypertension.Divergent conclusions have been published concerning the comparative responsiveness of hypertensives and normotensives, both human and experimental. The responses to several pressor drugs are stated to be larger in hypertensive than in normotensive rats by Sturtevant. 3 Olsen et al. 4 found an enhanced response to epinephrine and norepinephrine in renal hypertensive rats, whereas the responses to tyramine and phenethylamine were similar in hypertensives and normotensives. While the average responses to epinephrine and angiotensin of DCA-treated hypertensive

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Inhibition of noradrenaline biosynthesis and the level of blood pressure in spontaneously hypertensive rats and metacorticoid rats

Nikodijević¹,

Trajkov²,

Glavas³

et al. 1971

Naunyn-Schmiedebergs Arch. Pharmak.

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Mechanisms Responsible for the Elevated Blood Pressure in the Cerebral Hypertensive Rabbit

Cited by 10 publications

References 0 publications

Pathogenesis of Experimental Hypertension Produced by Carotid Sinus Area Constriction in Dogs

Pathogenesis of Experimental Hypertension Produced by Carotid Sinus Area Constriction in Dogs

Observations on the Responses of Rats with Spontaneous Hypertension and Control Rats to Pressor Drugs and to Hexamethonium

Inhibition of noradrenaline biosynthesis and the level of blood pressure in spontaneously hypertensive rats and metacorticoid rats

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