Mechanisms that may account for differential antibiotic susceptibilities among Coxiella burnetii isolates

Abstract

The Nine Mile, S Q217, and Priscilla isolates, representative of the three major genetic groups of Coxiella burnetii, are known to differ in their susceptibilities to antibiotics. Mechanisms potentially responsible for these differences were investigated. Accumulation of antibiotics by infected L929 cells and purified isolates was measured. In addition, C. burnetii plasmid-transformed Escherichia coli HB101 cells were used to study the possibility that different C.

Q fever

“…In susceptibility test studies, apparent susceptibility patterns have differed. Explanations for in vitro variations include differences among isolates and in the ages of the cell cultures used for inoculation of the organism-antimicrobial agent combination (81). The different degrees of resistance seen among different strains are most likely explained by variable permeability of the cell walls of these strains rather than by mutational alterations (81).…”

Q fever.

“…Explanations for in vitro variations include differences among isolates and in the ages of the cell cultures used for inoculation of the organism-antimicrobial agent combination (81). The different degrees of resistance seen among different strains are most likely explained by variable permeability of the cell walls of these strains rather than by mutational alterations (81).…”

Atypical Pneumonia Revisited

“…42,43 Treatment with tetracycline or rifampin results in prompt resolution of symptoms. [44][45][46][47][48][49] Some isolates of C. burnetii are susceptible to macrolides, others are not. 47,49…”