Mechanisms underlying celiac disease and its neurologic manifestations

Green, P. H. R.; Alaedini, Armin; Sander, Howard W.; Brannagan, Thomas H.; Latov, Norman; Chin, Russell L.

doi:10.1007/s00018-004-4109-9

Cited by 70 publications

(56 citation statements)

References 99 publications

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“…Symptoms are similar to other forms of cerebellar ataxia including gait and limb ataxia [32,37,38]. Myoclonus has also been reported in patients with CD and ataxia [42].…”

Section: Ataxiasupporting

confidence: 58%

Neuropsychiatric Features of Celiac Disease

Arnone

Conti²

2016

IJCD

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Celiac disease (CD) is a T-cell mediated genetically inherited autoimmune disease that has evolved over time. Formerly considered a pediatric disease, the rate of occurrence is now observed in individuals ranging from early childhood to senescence. Strict adherence to a gluten-free diet is the only currently available treatment for CD in order for individuals to avert future complications and malignancies. In the United States, the disease has shown widespread incidence and prevalence rates and affects 1% of the total population in not-at-risk groups. This number translates into 1 out of 133 people in the United States affected, making the disease almost 100 times more common than previously considered. While histological, genetic, incidence and prevalence of disease and quality of life research studies are replete in the extant literature, up until recently, neurological and psychological manifestations have also been studied among this cohort in relation to CD. Neurological conditions such as ataxia and neuropathy in CD have received the most research attention while much less attention has been paid to psychiatric conditions and cognitive functioning. The findings on cognitive functioning in CD have revolved largely around anecdotal reports and small clinical trials totaling approximately 200 patients of varying ages. Studies reporting neuropsychological test data are few and often do not include comprehensive test batteries in which to draw further conclusions on specific cognitive deficits. Larger, well-controlled studies are needed in order to form optimal diagnosis and implementation of specific support measures for individuals living with CD across the lifespan.

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“…Symptoms are similar to other forms of cerebellar ataxia including gait and limb ataxia [32,37,38]. Myoclonus has also been reported in patients with CD and ataxia [42].…”

Section: Ataxiasupporting

confidence: 58%

Neuropsychiatric Features of Celiac Disease

Arnone

Conti²

2016

IJCD

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“…Celiac disease is also characterized by systemic manifestations that contribute to a complex clinical presentation. Neurologic deficits, including axonal neuropathy and cerebellar ataxia, are among the most common extraintestinal symptoms associated with celiac disease (5,6). In addition, elevated levels of anti-gliadin Ab have been associated with idiopathic neuropathy and ataxia, even in the apparent absence of the characteristic mucosal pathology (7)(8)(9)(10).…”

mentioning

confidence: 99%

Immune Cross-Reactivity in Celiac Disease: Anti-Gliadin Antibodies Bind to Neuronal Synapsin I

Alaedini

Okamoto

Briani

et al. 2007

The Journal of Immunology

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Celiac disease is an immune-mediated disorder triggered by ingestion of wheat gliadin and related proteins in genetically susceptible individuals. In addition to the characteristic enteropathy, celiac disease is associated with various extraintestinal manifestations, including neurologic complications such as neuropathy, ataxia, seizures, and neurobehavioral changes. The cause of the neurologic manifestations is unknown, but autoimmunity resulting from molecular mimicry between gliadin and nervous system proteins has been proposed to play a role. In this study, we sought to investigate the immune reactivity of the anti-gliadin Ab response toward neural proteins. We characterized the binding of affinity-purified anti-gliadin Abs from immunized animals to brain proteins by one- and two-dimensional gel electrophoresis, immunoblotting, and peptide mass mapping. The major immunoreactive protein was identified as synapsin I. Anti-gliadin Abs from patients with celiac disease also bound to the protein. Such cross-reactivity may provide clues into the pathogenic mechanism of the neurologic deficits that are associated with gluten sensitivity.

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“…19 As for the mechanism of neurological manifestations of CD, current data point to molecular mimicry and intermolecular help as two possible mechanisms. 17 Rigamonti et.al. described two patients in whom celiac disease was diagnosed after the onset of peripheral neuropathy characterized by predominant motor nerve involvement in whom, after a gluten-free diet, significant improvement of symptoms and neurophysiological findings occurred.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 Neurologic manifestations, such as ataxia and peripheral neuropathy, are increasingly recognized to be the presenting features of CD. 17 Hadjivassiliou et.al. described 9 patients with neuromuscular disorders with CD, 3 patients had sensorimotor axonal peripheral neuropathy, 1 had axonal motor peripheral neuropathy, 1 had probable inclusion body myositis and axonal motor peripheral neuropathy, 1 had polymyositis and sensorimotor peripheral neuropathy, 1 had mononeuropathy multiplex, 1 had neuromyotonia, and 1 had polyneuropathy.…”

Section: Discussionmentioning

confidence: 99%

A Case of Celiac Disease Presenting with Recurrent Attacks of Quadriparesis

et al. 2017

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Celiac disease, once considered a rare disease in Bangladeshi population, have recently been reported more frequently. Recognition of celiac disease is not easy and a high degree of suspicion in required. Although the disease presents usually with malabsorption syndromes, atypical presentations also may occur which may cause confusion in making a prompt diagnosis. We intend to report a case who presented primarily with flaccid type of quadriparesis who ultimately was proven to be a case of celiac disease. Although neurological symptoms have been associated with celiac disease, motor weakness is very uncommon. We have proposed that in our case electrolyte imbalance have caused or contributed in causing this motor weakness.J Dhaka Medical College, Vol. 25, No.2, October, 2016, Page 138-141

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Mechanisms underlying celiac disease and its neurologic manifestations

Cited by 70 publications

References 99 publications

Neuropsychiatric Features of Celiac Disease

Neuropsychiatric Features of Celiac Disease

Immune Cross-Reactivity in Celiac Disease: Anti-Gliadin Antibodies Bind to Neuronal Synapsin I

A Case of Celiac Disease Presenting with Recurrent Attacks of Quadriparesis

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