Mechanisms underlying enhanced cardiac excitation contraction coupling observed in the senescent sheep myocardium

Dibb, Katharine M.; Rueckschloss, Uwe; Eisner, David; Isenberg, Gerrit; Trafford, Andrew W.

doi:10.1016/j.yjmcc.2004.09.005

Cited by 55 publications

(103 citation statements)

References 42 publications

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“…These and other studies have shown that the diastolic cytosolic Ca 2+ level (Howlett et al, 2006) and the releasable Ca 2+ pool (Dibb et al, 2004) from the SR are not very different between young and senescent cardiomyocytes. Therefore, a leaky Ca 2+ pathway across the SR membrane due to modification of the RyR2 channel, or its associated components, likely contributes to the elevated Ca 2+ spark activity in senescent cardiomyocytes.…”

Section: Differential Properties Of Ca 2+ Sparks In Cardiac and Skelesupporting

confidence: 68%

Altered Ca2+ sparks in aging skeletal and cardiac muscle

Weisleder

2008

Ageing Research Reviews

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Ca 2+ sparks are the fundamental units that comprise Ca 2+ -induced Ca 2+ release (CICR) in striated muscle cells. In cardiac muscle, spontaneous Ca 2+ sparks underlie the rhythmic CICR activity during heart contraction. In skeletal muscle, Ca 2+ sparks remain quiescent during the resting state and are activated in a plastic fashion to accommodate various levels of stress. With aging, the plastic Ca 2+ spark signal becomes static in skeletal muscle, whereas loss of CICR control leads to leaky Ca 2+ spark activity in aged cardiomyocytes. Ca 2+ spark responses reflect the integrated function of the intracellular Ca 2+ regulatory machinery centered around the triad or dyad junctional complexes of striated muscles, which harbor the principal molecular players of excitation-contraction coupling. This review highlights the contribution of age-related modification of the Ca 2+ release machinery and the effect of membrane structure and membrane cross-talk on the altered Ca 2+ spark signaling during aging of striated muscles.

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Section: Differential Properties Of Ca 2+ Sparks In Cardiac and Skelesupporting

confidence: 68%

Altered Ca2+ sparks in aging skeletal and cardiac muscle

Weisleder

2008

Ageing Research Reviews

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“…The most likely mechanisms that account for these alterations in cardiac excitation-contraction (E-C) coupling are L-type Ca 2+ current (I CaL ) and altered activity or expression of Ca 2+ regulatory proteins which may lead to impaired SR function. However, previous studies performed in different species have reported [7,8] unchanged [9] or increased [10] I CaL densities with age in cardiac myocytes.…”

Section: Introductionmentioning

confidence: 75%

Swimming exercise reverses aging-related contractile abnormalities of female heart by improving structural alterations

Ozturk

Olğar

et al. 2017

Cardiol J.

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“…Однако убедительных данных об из-менении калиевых токов в ходе старения не получено. Также нет достаточно достоверной информации об из-менении эффективности работы Na-Ca обменного механизма, способного влиять на длительность потен-циала действия [33].…”

Section: изменения процессов возбуждения электромеханического сопряжunclassified

“…В настоящее время можно считать доказан-ным факт замедления работы Са-АТФазы с возрастом [34][35][36], при этом вклад Na-Ca-обмена в расслабле-ние кардиомиоцитов не меняется [33]. Не обнаружено также значительного изменения роли саркоплазмати-ческого ретикулума в освобождении Са 2+ внутрь цито-плазмы при активации сокращений [34].…”

Section: изменения процессов возбуждения электромеханического сопряжunclassified