Mechanisms underlying intestinal adaptation after massive intestinal resection in the rat

The influence of nutrients, biliary-pancreatic secretions, and systemic trophic hormones on intestinal adaptation in a Roux-en-Y bypass model

“…A number of mucosal trophic factors have also been implicated as having a role in controlling stimulation and differentiation of the epithelium of the gastrointestinal tract [21,22]. Of these, glucagon-like peptide-2 (GLP-2) [12,23], insulin-like growth factor-1 (IGF-1) [24][25][26], basic fibroblast growth factor (bFGF) [27,28], epidermal growth factor (EGF) [29][30][31], and keratinocyte growth factor (KGF) [32][33][34] are the best characterized.…”

Oral Insulin Enhances Intestinal Regrowth Following Massive Small Bowel Resection in Rat

“…Over the past decades, much research has focused on factors that may promote intestinal regrowth. There is a growing body of evidence suggesting that different hormones and peptide growth factors may stimulate postresection adaptive hyperplasia (2,3).…”

A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome

“…Typical causes are necrotizing enterocolitis (NEC), congenital atresia, or midgut volvulus [1][2][3]. After such major losses of absorptive surface area, the phenomenon of adaptation can significantly up-regulate the nutrient transport capacity of the residual small bowel [4,5].…”

“…A number of factors have been suggested to play a role in controlling the stimulation and differentiation of the epithelium of the gastrointestinal tract [5,7]. Of these factors, epidermal growth factor (EGF) has been shown to have a role both in maintaining epithelial tissues as well as controlling intestinal adaptation [8][9][10].…”