Mechanisms underlying muscle fatigue differ between multiple sclerosis patients and controls: A combined electrophysiological and neuroimaging study

Steens, Anneke; Heersema, Dorothea; Maurits, Natasha M.; Renken, Remco; Zijdewind, Inge

doi:10.1016/j.neuroimage.2011.11.038

Cited by 68 publications

(81 citation statements)

References 56 publications

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“…In a subsequent study with similar groups of participants, Steens et al (65) compared the adjustments in the activation signal generated by the nervous system during a fatiguing contraction with the hand muscle. The variance in performance fatigability (decline in MVC force) was explained by different outcome measures for the two groups of participants.…”

Section: Human Performance and Fatiguementioning

confidence: 99%

Translating Fatigue to Human Performance

Enoka

Duchateau

2016

Medicine &Amp; Science in Sports &Amp; Exercise

630

582

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Despite flourishing interest in the topic of fatigue—as indicated by the many presentations on fatigue at the 2015 annual meeting of the American College of Sports Medicine—surprisingly little is known about its impact on human performance. There are two main reasons for this dilemma: (1) the inability of current terminology to accommodate the scope of the conditions ascribed to fatigue, and (2) a paucity of validated experimental models. In contrast to current practice, a case is made for a unified definition of fatigue to facilitate its management in health and disease. Based on the classic two-domain concept of Mosso, fatigue is defined as a disabling symptom in which physical and cognitive function is limited by interactions between performance fatigability and perceived fatigability. As a symptom, fatigue can only be measured by self-report, quantified as either a trait characteristic or a state variable. One consequence of such a definition is that the word fatigue should not be preceded by an adjective (e.g., central, mental, muscle, peripheral, and supraspinal) to suggest the locus of the changes responsible for an observed level of fatigue. Rather, mechanistic studies should be performed with validated experimental models to identify the changes responsible for the reported fatigue. As indicated by three examples (walking endurance in old adults, time trials by endurance athletes, and fatigue in persons with multiple sclerosis) discussed in the review, however, it has proven challenging to develop valid experimental models of fatigue. The proposed framework provides a foundation to address the many gaps in knowledge of how laboratory measures of fatigue and fatigability impact real-world performance.

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Section: Human Performance and Fatiguementioning

confidence: 99%

Translating Fatigue to Human Performance

Enoka

Duchateau

2016

Medicine &Amp; Science in Sports &Amp; Exercise

630

582

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“…Previous research has explored the strength and muscle physiology of the lower extremities of individuals with MS rather than the motor control of the lower extremity musculature. [4][5][6]11,24 Furthermore, it is relatively unknown whether the current rehabilitation strategies for individuals with MS can improve the motor control of the ankle plantarflexor musculature.…”

Section: Introductionmentioning

confidence: 99%

Neurorehabilitation Strategies Focusing on Ankle Control Improve Mobility and Posture in Persons With Multiple Sclerosis

Davies

Arpin

Volkman

et al. 2015

Journal of Neurologic Physical Therapy

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The outcomes of this exploratory study suggest that the neurorehabilitation protocol employed in this investigation has the potential to promote clinically relevant improvements in the ankle plantarflexor control, standing postural balance, ankle plantarflexion strength, and the mobility of individuals with MS. Video abstract available for more insights from the authors (see Video, Supplemental Digital Content 1, http://links.lww.com/JNPT/A110).

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“…Change in total MOS Pain score was endocrine influences and axonal injury. (43) In addition, muscle fatigue has also been demonstrated in people with MS (44) and may contribute to the overall fatigue reported by individuals with MS. Thus, this lack of clarity related to fatigue in MS makes it difficult to understand the potential mechanisms by which MT may have a positive impact on fatigue.…”

Section: Discussionmentioning

confidence: 99%

Impact of Massage Therapy on Fatigue, Pain, and Spasticity in People with Multiple Sclerosis: a Pilot Study

Backus

Manella

Bender

et al. 2016

IJTMB

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Background: Multiple sclerosis (MS) is a chronic, immune-mediated, inflammatory disease that leads to fatigue, pain, and spasticity, as well as other sensorimotor and cognitive changes. Often traditional medical approaches are ineffective in alleviating these disruptive symptoms. Although about one-third of surveyed individuals report they use massage therapy (MT) as an adjunct to medical treatment, there is little empirical evidence that MT is effective for symptom management in people with MS.Purpose: To measure the effects of MT on fatigue, pain, spasticity, perception of health, and quality of life in people with MS.Setting: Not-for-profit long-term care facility. Participants: Twenty-four of 28 enrolled individuals with MS (average age = 47.38, SD = 13.05; 22 female) completed all MT sessions and outcome assessments.Research Design: Nonrandomized, pre-post pilot study.Intervention: Standardized MT routine one time a week for six weeks. Main Outcome Measure(s): Modified Fatigue Index Scale (MFIS), MOS Pain Effects Scale (MOS Pain), and Modified Ashworth Scale (MAS). Secondary outcome measures: Mental Health Inventory (MHI) and Health Status Questionnaire (HSQ).Results: There was a significant improvement in MFIS (p < .01), MOS Pain (p < .01), MHI (p < .01), and HSQ (p < .01), all with a large effect size (ES) (Cohen's d = -0.76, 1.25, 0.93, -1.01, respectively). There was a significant correlation between change scores on the MFIS and the MOS Pain (r = 0.532, p < .01), MHI (r = -0.647, p < .01), and subscales of the HSQ (ranging from r = -0.519, to -0.619, p < .01).Conclusions: MT as delivered in this study is a safe and beneficial intervention for management of fatigue and pain in people with MS. Decreasing fatigue and pain appears to correlate with improvement in quality of life, which is meaningful for people with MS who have a chronic disease resulting in long-term health care needs.

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Mechanisms underlying muscle fatigue differ between multiple sclerosis patients and controls: A combined electrophysiological and neuroimaging study

Cited by 68 publications

References 56 publications

Translating Fatigue to Human Performance

Translating Fatigue to Human Performance

Neurorehabilitation Strategies Focusing on Ankle Control Improve Mobility and Posture in Persons With Multiple Sclerosis

Impact of Massage Therapy on Fatigue, Pain, and Spasticity in People with Multiple Sclerosis: a Pilot Study

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