Mechanisms underlying sonoporation: Interaction between microbubbles and cells

High Throughput and Highly Controllable Methods for In Vitro Intracellular Delivery

“…Lastly, sonoporation refers to the use of ultrasound acoustic waves to produce membrane poration through pressure fluctuation induced stresses, [42] stable microbubble cavitation, or inertial microbubble cavitation. [43][44][45]…”

Modifications of Plasma Membrane Organization in Cancer Cells for Targeted Therapy

“…Sonoporation is based on the propagation of ultrasounds through the media and tissues exerting direct radiation and secondary forces resulting from the interaction between the tissue, surrounding media, and microbubbles [252]. Consequently, the main factors contributing to the effectiveness of sonoporation-based therapies include acoustical driving parameters, properties of the environment surrounding the targeted tissue, and additionally introduced cavitation agents [252]. Lentacker et al identified three main ultrasound settings enabling sonoporation: (i) application of ultrasounds without additional cavitation agents (ii) stable cavitation exerted by low-intensity ultrasound (iii) inertial cavitation evoked by high-intensity ultrasound [253].…”

“…Although not mandatory, they are frequently used together with ul-trasounds to increase the sonoporation efficiency through cavitation [249][250][251]. Sonoporation is based on the propagation of ultrasounds through the media and tissues exerting direct radiation and secondary forces resulting from the interaction between the tissue, surrounding media, and microbubbles [252]. Consequently, the main factors contributing to the effectiveness of sonoporation-based therapies include acoustical driving parameters, properties of the environment surrounding the targeted tissue, and additionally introduced cavitation agents [252].…”

Anthocyanins Recovered from Agri-Food By-Products Using Innovative Processes: Trends, Challenges, and Perspectives for Their Application in Food Systems

“…Acoustic cavitation enables the formation of micropores and even the disruption of cellular structures. Therefore, the sonoporation effect is a powerful mechanism for extracting bioactive compounds from plant matrices because it favors the release of phytochemicals found inside plant cells into the extraction solvent [ 157 ]. Likewise, the sonication treatment also favors phytochemicals diffusion into the liquid medium due to the temperature increase and turbulence provided by acoustic cavitation [ 20 , 152 ].…”