Mechanisms underlying TRPV4-mediated regulation of miR-146a expression
Bidisha Dutta,
Manisha Mahanty,
Lakshmyya Kesavalu
et al.
Abstract:Persistent inflammation is a major contributor in the development of various inflammatory diseases like atherosclerosis. Our study investigates how transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, interacts with microRNA-146a (miR-146a), within the context of inflammation and atherosclerosis. Micro-RNAs play a critical role in controlling gene expression, and miR-146a is notable for its anti-inflammatory actions. TRPV4 is activated by diverse soluble and mechanical stimuli, and… Show more
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