Mechanisms Underlying Visuospatial Working Memory Impairments in Schizophrenia

Ichinose, Megan; Park, Sohee

doi:10.1007/7854_2019_99

Cited by 6 publications

(3 citation statements)

References 153 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1. However, a recent study under ketamine showed a similar reduction in delay-period tuning in prefrontal cortex, but this time associated with decreased precision [39], which suggests that manipulation of NMDARs may have an important impact on noise parameters [40,41] that compensate for the influence of bump shape on diffusivity (as for Model 1 in Fig. 2).…”

Section: Insufficient and Inconsistent Experimental Constraints On Plausible Computational Modelsmentioning

confidence: 91%

Towards biologically constrained attractor models of schizophrenia

Stein

Barbosa

Compte

2021

Current Opinion in Neurobiology

View full text Add to dashboard Cite

Highlights• People with schizophrenia have quantitative working memory (WM) deficits • WM deficits cannot be readily mapped on the stability of continuous attractors • Different attractor models yield inconsistent behavioral predictions upon changes in E/I ratio • Grouping different perturbations under E/I ratio can be inadequate for some deficits • Insufficient experimental and computational understanding precludes model selection • We need data showing NMDAR-dependence of rate tuning and correlated noise in WM circuits

show abstract

Section: Insufficient and Inconsistent Experimental Constraints On Plausible Computational Modelsmentioning

confidence: 91%

Towards biologically constrained attractor models of schizophrenia

Stein

Barbosa

Compte

2021

Current Opinion in Neurobiology

View full text Add to dashboard Cite

show abstract

“…Working memory is a limited-capacity, active short-term memory system that maintains information to guide and control behavior [74]. Working memory deficits are a permanent cognitive feature of schizophrenia and memory impairments are present during the prodromal stage and persist throughout schizophrenia [74]. Spatial working memory deficits were observed in schizophrenic patients in a spatial delayedresponse task (DRT) [75].…”

Section: Working Memorymentioning

confidence: 99%

Psychedelics action and schizophrenia

Maćkowiak

2023

Pharmacol. Rep

View full text Add to dashboard Cite

Psychedelics are compounds acting by serotonin 5-hydroxytryptamine (5-HT)2A receptor activation and induce several behavioral responses. They are of special interest because of their positive effects on neuropsychiatric disorders (depression and posttraumatic stress disorder). However, several findings revealed that some psychedelic actions are similar to symptoms observed in schizophrenia (psychosis, sensorimotor gating impairments, attention, and working memory deficits) which might limit their clinical applications. Psychedelics activate some neurotransmitters, i.e., serotonergic, and glutamatergic, that are also impaired in schizophrenia. Therefore, the neurobiological background of psychedelics and schizophrenia is partially similar. Another important aspect to discuss is the perspective of using psychedelics in schizophrenia therapy. Postmortem studies showed a loss of synapses in schizophrenia, and the positive effects of psychedelics on neuroplasticity (synaptogenesis, neurogenesis, and neuritogenesis) might be essential in the context of schizophrenia therapy. However, because of psychedelics' psychotic action, the recommended doses of psychedelics in schizophrenia treatment are not established, and subpsychedelic dosing or microdosing are considered. Exploratory studies are needed to determine the tolerability of treatment and appropriate dosing regimen. Another therapeutic option is using non-hallucinogenic psychedelic analogs that also induce neuroplastic outcomes but do not have psychotogenic effects. Further preclinical and clinical studies are needed to recognize the potential effectiveness of 5-HT2A agonists in schizophrenia therapy.

show abstract

“…Disrupted early visual processing in patients with severe mental illness has also been linked to dysfunction in neurotransmission systems [ 62 ], with reduced visual cortical GABA concentration associated with aberrant surround suppression in patients with schizophrenia [ 63 , 64 ]. With regards to everyday life, early visual processing deficits may influence psychosocial and daily functioning through their impact on patients' ability to focus, encode relevant information [ 65 ], and directing attention toward relevant target stimuli in the surroundings. Being able to both extract and focus on relevant information and joint attention with people in the surroundings is important for both working life and psychosocial functioning [ 66 , 67 ], as well as patients daily living autonomy [ 68 ].…”

Section: Discussionmentioning

confidence: 99%