Mechanistic Aspects of Apiaceae Family Spices in Ameliorating Alzheimer’s Disease

Sharma, Niti; Tan, Mario A.; An, Seong Soo A.

doi:10.3390/antiox10101571

Cited by 15 publications

(15 citation statements)

References 119 publications

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“…Numerous essential oils have shown promise in inhibiting cholinesterase, a key factor in AD progression. The members of the Apiaceae family have been extensively studied to substantiate their traditional medicinal uses, with a primary emphasis on elucidating their neuroprotective mechanisms [25] …”

Section: Resultsmentioning

confidence: 99%

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Exploring Astrodaucus orientalis (L.) Drude: Phytochemical Analysis and its Biological Potential Against Alzheimer's and Diabetes

Yuca,

Aydin,

Karakaya

et al. 2024

Chemistry & Biodiversity

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In current study antioxidant, antidiabetic, antimicrobial, anticholinesterase, and human carbonic anhydrase I, and II (hCA I and II) isoenzymes inhibition activities of Astrodaucus orientalis different parts were investigated. Achetylcholinesterse (AChE) and butyrylcholinesterse (BChE) inhibitory activities of octyl acetate were determined via molecular docking. Quantitative assessment of specific secondary metabolites was conducted using LC‐MS/MS. An examination of chemical composition of essential oils was carried out by GC‐MS/MS. A thorough exploration of plant's anatomical characteristics was undertaken. The highest phenolics level and DPPH antioxidant capacity were seen in root and fruit. Fruit essential oil demonstrated the highest AChE inhibition (44.13±3.61%), while root dichloromethane sub‐extract had the best inhibition towards BChE (86.13±2.58%). Cytosolic hCA I, and II isoenzymes were influentially inhibited by root oil with 1.974 and 2.207 µM IC50 values, respectively. The most effective extracts were found to be root all extract/sub‐extracts (except water) against C. tropicalis and C. krusei strains with MIC value 160> µg/mL. Sabinene (29.4%), α‐pinene (20.2%); octyl acetate (54.3%); myrcene (28.0%); octyl octanoate (71.3%) were found principal components of aerial parts, roots, flowers, and fruits, respectively. Flower essential oil, fruit dicloromethane and ethyl acetate exhibited potent α‐glucosidase inhibitory activity with 900, 40, and 937 µg/mL IC50 values, respectively.

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Section: Resultsmentioning

confidence: 99%

“…The members of the Apiaceae family have been extensively studied to substantiate their traditional medicinal uses, with a primary emphasis on elucidating their neuroprotective mechanisms. [25]…”

Section: Analysis Of Ache and Bche Inhibition Activitiesmentioning

confidence: 99%

Exploring Astrodaucus orientalis (L.) Drude: Phytochemical Analysis and its Biological Potential Against Alzheimer's and Diabetes

Yuca,

Aydin,

Karakaya

et al. 2024

Chemistry & Biodiversity

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show abstract

“…Further, the concentration of reduced GSH and the ratio of GSH/GSSG were found to be significantly increased, which were reduced due to scopolamine treatment [ 75 ]. The authors suggested that the antioxidant effect of UD, especially UDR, may counteract neurodegenerative diseases such as Alzheimer’s disease [ 75 , 76 ].…”

Section: Antioxidant Potential Of Udmentioning

confidence: 99%

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

Jaiswal

Lee

2022

Antioxidants

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Urtica dioica (UD) is a multi-functional plant known to be used as both food and medicine from ancient times. The plant has the potential to be used as a fertilizer and for biological pest control. It is also used in textile and related industries for its quality fibers. In the recent past, the plant has received great attention for its numerous important biological activities and food applications. The antioxidant activity of UD is the crucial factor supporting its important biological activities, such as anticancer, antidiabetic and anti-inflammatory properties. The antioxidant activity of UD is also found to be protective in different organs, including the brain, liver, lungs, kidney, ovary, and uterus, and may also be protective against diseases associated with these organs. Few clinical studies have endorsed the antioxidant potential of UD in patients. The current work is an attempt to comprehensively compile and discuss the antioxidant activity of UD from in vitro, in vivo and human studies. The insights of the current study would be helpful in getting a panoramic view of the antioxidant potential of UD, and provide direction for optimizing and developing it for therapeutic applications against important diseases and conditions in the near future.

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“…Recently, the Food and Drug Administration (FDA) approved an antibody drug (Aduhelm), which may improve AD symptoms. Yet, all these allopathy drugs have associated side effects, ranging from minor headache to swelling and brain haemorrhaging [3]. In this regard, plants could provide an effective and safer source of bioactive compounds to be used as a drug.…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, plants could provide an effective and safer source of bioactive compounds to be used as a drug. Researchers have identified several plants with neuroprotective properties, like AChE inhibition, retarding atypical aggregation and scavenging free radicles, which protect against oxidative stress [3][4][5]. Additionally, several bioactive compounds have anti-inflammatory properties and reduce the activity of pro-inflammatory markers (interleukins (IL-6, IL-1β), nitric oxide (NO), tumor necrosis factor-α (TNF-α) and inflammatory proteins inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)) [3,6].…”

Section: Introductionmentioning

confidence: 99%

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

Tan

Sharma

2022

Antioxidants

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Plant-derived (phyto) carbazole alkaloids are an important class of compounds, presented in the family of Rutaceae (Genera Murraya, Clausena, Glycosmis, Micromelum and Zanthoxylum). Due to several significant biological activities, such as antitumor, antibacterial, antiviral, antidiabetic, anti-HIV and neuroprotective activities of the parent skeleton (3-methylcarbazole), carbazole alkaloids are recognized as an important class of potential therapeutic agents. Neurodegenerative diseases (NDs) may exhibit a vast range of conditions, affecting neurons primarily and leading ultimately to the progressive losses of normal motor and cognitive functions. The main pathophysiological indicators of NDs comprise increasing atypical protein folding, oxidative stresses, mitochondrial dysfunctions, deranged neurotransmissions and neuronal losses. Phyto-carbazole alkaloids can be investigated for exerting multitarget approaches to ameliorating NDs. This review presents a comprehensive evaluation of the available scientific literature on the neuroprotective mechanisms of phyto-carbazole alkaloids from the Rutaceae family in ameliorating NDs.

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Mechanistic Aspects of Apiaceae Family Spices in Ameliorating Alzheimer’s Disease

Cited by 15 publications

References 119 publications

Exploring Astrodaucus orientalis (L.) Drude: Phytochemical Analysis and its Biological Potential Against Alzheimer's and Diabetes

Exploring Astrodaucus orientalis (L.) Drude: Phytochemical Analysis and its Biological Potential Against Alzheimer's and Diabetes

Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities

Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases

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