Visual Impairment and Blindness - What We Know and What We Have to Know 2020
DOI: 10.5772/intechopen.83016
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Mechanistic Dissection of Macular Degeneration Using the Phosphorylation Interactome

Abstract: In the current study, we suggest that phosphorylation reactions of specific proteins in mitochondria and the nucleus are a key step in the progression of age-related macular degeneration (AMD). To determine the molecular mechanism of AMD, we examined proteomic changes under oxidative stress to establish the protein interaction map using in vitro and in vivo models that mimic the complex and progressive characteristics of AMD. We postulated that apoptosis can be initiated by phosphorylation reactions under chro… Show more

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Cited by 2 publications
(1 citation statement)
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References 75 publications
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“…We have investigated the therapeutic applications of retinal degeneration by focusing on antiapoptotic and neuroprotective mechanisms using a functional proteomics approach. Previously, we demonstrated that the retinal expression of erythropoietin (EPO), the visual cycle, and the subsequent kinase phosphorylations are interconnected to the circadian clock in anticipation of daily light onset . Our data demonstrated that the EPO is a neuroprotective molecule involved in the inhibition of the apoptotic pathway, including BCL-xL and caspase-9.…”
Section: Introductionmentioning
confidence: 99%
“…We have investigated the therapeutic applications of retinal degeneration by focusing on antiapoptotic and neuroprotective mechanisms using a functional proteomics approach. Previously, we demonstrated that the retinal expression of erythropoietin (EPO), the visual cycle, and the subsequent kinase phosphorylations are interconnected to the circadian clock in anticipation of daily light onset . Our data demonstrated that the EPO is a neuroprotective molecule involved in the inhibition of the apoptotic pathway, including BCL-xL and caspase-9.…”
Section: Introductionmentioning
confidence: 99%