Mechanistic evaluation of Ursolic acid against rotenone induced Parkinson’s disease– emphasizing the role of mitochondrial biogenesis

Peshattiwar, Vaibhavi; Muke, Suraj; Kaikini, Aakruti; Bagle, Sneha; Dighe, Vikas; Sathaye, Sadhana

doi:10.1016/j.brainresbull.2020.03.003

Cited by 22 publications

(12 citation statements)

References 55 publications

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“…Recently it has been shown that prolonged administration of UA affected the functionality of mitochondrial electron transport chain. In brain mitochondria, UA improved the enzymatic activity of mitochondrial complex I in rotenone-induced Parkinson's disease model in vivo and increased the expression of mitochondrially encoded cytochrome c oxidase 1 (MrCO1) [81]. Mitochondrial membrane potential has also been found to be sustained by UA (at 10 µM concentration for 10 min) in an excitotoxicity model of hippocampal neurons [79].…”

Section: Neuroprotective Effects Of Ursolic and Oleanolic Acids 41 Neuroprotective Effects Of Ursolic And Oleanolic Acids In Neurodegenermentioning

confidence: 97%

Ursolic and Oleanolic Acids: Plant Metabolites with Neuromodulatory Potential

Gudoityte¹,

Arandarčikaitė²,

Mažeikienė³

et al. 2021

Preprint

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Ursolic and oleanolic acids are secondary plant metabolites that are known to be involved in the plant defence system against water loss and pathogens. Nowadays these triterpenoids are also regarded as potential pharmaceutical compounds and there is mounting experimental data that either purified compounds or triterpenoid-enriched plant extracts exert various beneficial effects, including anti-oxidative, anti-inflammatory and anticancer, on model systems of both human or animal origin. Some of those effects have been linked to the ability of ursolic and oleanolic acids to modulate intracellular antioxidant systems and also inflammation- and cell death-related pathways. Therefore, our aim was to review the current knowledge about the distribution of ursolic and oleanolic acids in plants, bioavailability and pharmacokinetic properties of these triterpenoids and their derivatives, and to discuss their neuromodulatory effects in vitro and in vivo.

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Section: Neuroprotective Effects Of Ursolic and Oleanolic Acids 41 Neuroprotective Effects Of Ursolic And Oleanolic Acids In Neurodegenermentioning

confidence: 97%

Ursolic and Oleanolic Acids: Plant Metabolites with Neuromodulatory Potential

Gudoityte¹,

Arandarčikaitė²,

Mažeikienė³

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…The animals were subjected to an open field test for 5 min (Peshattiwar et al, 2020). Before each trial, 75% alcohol was used to wipe the bottom of the box to remove the odor and clean up the feces to prevent the residual odor between the two experiments.…”

Section: Open Field Testmentioning

confidence: 99%

“…The rats were placed on a rotating rod instrument and adapted for 1 min at 5 r/min; then, the instrument was adjusted to 13 r/min for testing (Peshattiwar et al, 2020). The time from the start of rotating to the fall of the rotating rod was measured.…”

Section: Rotating Rod Experimentsmentioning

confidence: 99%

Huangqin Decoction Exerts Beneficial Effects on Rotenone-Induced Rat Model of Parkinson's Disease by Improving Mitochondrial Dysfunction and Alleviating Metabolic Abnormality of Mitochondria

Gao

Cao

et al. 2022

Front. Aging Neurosci.

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Parkinson's disease (PD) is a common neurodegenerative disease, and the pathogenesis of PD is closely related to mitochondrial dysfunction. Previous studies have indicated that traditional Chinese medicine composition of Huangqin Decoction (HQD), including Scutellariae Radix, licorice, and Paeoniae Radix Alba, has therapeutic effects on PD, but whether HQD has a therapeutic effect on PD has not been reported. In this study, the protective effects of HQD on rotenone-induced PD rats were evaluated by behavioral assays (open field, rotating rod, suspension, gait, inclined plate, and grid) and immunohistochemistry. The mechanisms of HQD on attenuation of mitochondrial dysfunction were detected by biochemical assays and mitochondrial metabolomics. The results showed that HQD (20 g/kg) can protect rats with PD by improving motor coordination and muscle strength, increasing the number of tyrosine hydroxylase (TH)-positive neurons in rats with PD. Besides, HQD can improve mitochondrial dysfunction by increasing the content of adenosine triphosphate (ATP) and mitochondrial complex I. Mitochondrial metabolomics analysis revealed that the ketone body of acetoacetic acid (AcAc) in the rotenone group was significantly higher than that of the control group. Ketone bodies have been known to be used as an alternative energy source to provide energy to the brain when glucose was deficient. Further studies demonstrated that HQD could increase the expression of glucose transporter GLUT1, the content of tricarboxylic acid cycle rate-limiting enzyme citrate synthase (CS), and the level of hexokinase (HK) in rats with PD but could decrease the content of ketone bodies [AcAc and β-hydroxybutyric acid (β-HB)] and the expression of their transporters (MCT1). Our study revealed that the decrease of glucose metabolism in the rotenone group was parallel to the increase of substitute substrates (ketone bodies) and related transporters, and HQD could improve PD symptoms by activating the aerobic glycolysis pathway.

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“…UA has been shown to increase the activity of CAT [ 80 , 81 , 82 ], SOD [ 3 , 77 , 79 , 81 ], glutathione (GSH) [ 3 , 80 , 81 , 82 ], GP [ 78 ] and to activate the Nrf2-pathway [ 83 , 84 ]. The final result of the majority of experiments was the reduction of lipid peroxidation expressed as the decrease in the level of malondialdehyde (MDA) [ 3 , 80 , 81 , 82 , 83 , 84 ]. Ex vivo UA has been also able to decrease the activity of α-chymotrypsin, which is known as the marker of oxidative injury [ 3 ].…”

Section: Neuroprotective Effects Of Ursolic and Oleanolic Acidsmentioning

confidence: 99%

“…Recently it has been shown that prolonged administration of UA affected the functionality of mitochondrial electron transport chain. In brain mitochondria, UA improved the enzymatic activity of mitochondrial complex I in rotenone-induced Parkinson’s disease model in vivo and increased the expression of mitochondrially encoded cytochrome c oxidase 1 (MrCO1) [ 81 ]. Mitochondrial membrane potential has also been found to be sustained by UA (at 10 μM concentration for 10 min) in an excitotoxicity model of hippocampal neurons [ 79 ].…”

Section: Neuroprotective Effects Of Ursolic and Oleanolic Acidsmentioning

confidence: 99%

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential

Gudoityte

Arandarčikaitė

Mažeikienė

et al. 2021

IJMS

View full text Add to dashboard Cite

Ursolic and oleanolic acids are secondary plant metabolites that are known to be involved in the plant defence system against water loss and pathogens. Nowadays these triterpenoids are also regarded as potential pharmaceutical compounds and there is mounting experimental data that either purified compounds or triterpenoid-enriched plant extracts exert various beneficial effects, including anti-oxidative, anti-inflammatory and anticancer, on model systems of both human or animal origin. Some of those effects have been linked to the ability of ursolic and oleanolic acids to modulate intracellular antioxidant systems and also inflammation and cell death-related pathways. Therefore, our aim was to review current studies on the distribution of ursolic and oleanolic acids in plants, bioavailability and pharmacokinetic properties of these triterpenoids and their derivatives, and to discuss their neuroprotective effects in vitro and in vivo.

show abstract

Mechanistic evaluation of Ursolic acid against rotenone induced Parkinson’s disease– emphasizing the role of mitochondrial biogenesis

Cited by 22 publications

References 55 publications

Ursolic and Oleanolic Acids: Plant Metabolites with Neuromodulatory Potential

Ursolic and Oleanolic Acids: Plant Metabolites with Neuromodulatory Potential

Huangqin Decoction Exerts Beneficial Effects on Rotenone-Induced Rat Model of Parkinson's Disease by Improving Mitochondrial Dysfunction and Alleviating Metabolic Abnormality of Mitochondria

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential

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