Mechanistic Image-Based Modelling: Concepts and Applications

Menshykau, Denis; Tanaka, Simon

doi:10.1007/164_2019_328

Concepts and Principles of Pharmacology

2019

DOI: 10.1007/164_2019_328

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Mechanistic Image-Based Modelling: Concepts and Applications

Denis Menshykau¹,

Simon Tanaka²

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2022

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“…Recent advances in imaging methods have made image-based systems biology from the cellular to whole-organ spatial scale a reality 1 – 3 . Image-based vascular systems biology involves the acquisition and integration of high-fidelity vasculature related data across spatial scales, and its incorporation in computational models for a holistic understanding of the role of the vascular microenvironment in health and disease.…”

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confidence: 99%

VascuViz: a multimodality and multiscale imaging and visualization pipeline for vascular systems biology

et al. 2022

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Despite advances in imaging, image-based vascular systems biology has remained challenging because blood vessel data is often available only from a single modality or at a given spatial scale, and cross-modality data are difficult to integrate. Therefore, there is an exigent need for a multimodality pipeline that enables ex vivo vascular imaging with MRI, CT and optical microscopy of the same sample, while permitting imaging with complementary contrast mechanisms from the whole-organ to endothelial cell spatial scales. To achieve this, we developed ‘VascuViz’ – an easy-to-use method for simultaneous 3D imaging and visualization of the vascular microenvironment using MRI, CT and optical microscopy in the same intact, unsectioned tissue. The VascuViz workflow permits multimodal imaging with a single labeling step using commercial reagents and is compatible with diverse tissue types and protocols. VascuViz’s interdisciplinary utility in conjunction with novel data visualization approaches opens up new vistas in image-based vascular systems biology.

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confidence: 99%

VascuViz: a multimodality and multiscale imaging and visualization pipeline for vascular systems biology

et al. 2022

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Mechanistic Image-Based Modelling: Concepts and Applications

Cited by 1 publication

References 117 publications

VascuViz: a multimodality and multiscale imaging and visualization pipeline for vascular systems biology

VascuViz: a multimodality and multiscale imaging and visualization pipeline for vascular systems biology

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