Mechanistic implication of decreased plasma atrial natriuretic peptide level for transient rise in the atrial capture threshold early after ICD or CRT-D implantation

Ogawa, Kazuyoshi; Yoshida, Kentaro; Uehara, Yoshiko; Ebine, Mari; Kimata, Akira; Nishina, Hidetaka; Takeyasu, Noriyuki; Noguchi, Yuichi; Ieda, Masaki; Aonuma, Kazutaka; Nogami, Akihiko

doi:10.1007/s10840-018-0409-0

Cited by 3 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yoshida et al also proposed the original index ANP/BNP ratio, which may be more sensitive to a heart condition and better reflects atrial integrity than ANP or BNP alone. Patients with more severe HF (higher BNP) and more advanced atrial fibrosis (lower ANP) have a much lower ANP/BNP ratio than those without these conditions [106]. However, this interpretation of the ANP/BNP ratio needs validation in future studies, and assessment of the MR-proANP /BNP ratio is also of interest with respect to atrial remodeling in patients with HF and AF.…”

Section: Depletion Of Anp In Af Patients With Atrial Remodelingmentioning

confidence: 99%

Clinical Applications of Natriuretic Peptides in Heart Failure and Atrial Fibrillation

Baba

Yoshida

Ieda

2019

IJMS

Self Cite

View full text Add to dashboard Cite

Natriuretic peptides (NPs) have become important diagnostic and prognostic biomarkers in cardiovascular diseases, particularly in heart failure (HF). Diagnosis and management of coronary artery disease and atrial fibrillation (AF) can also be guided by NP levels. When interpreting NP levels, however, the caveat is that age, sex, body mass index, renal dysfunction, and race affect the clearance of NPs, resulting in different cut-off values in clinical practice. In AF, NP levels have been associated with incident AF in the general population, recurrences after catheter ablation, prediction of clinical prognosis, and the risk of stroke. In this article, we first review and summarize the current evidence and the roles of B-type NP and atrial NP in HF and coronary artery disease and then focus on the increasing utility of NPs in the diagnosis and management of and the research into AF.

show abstract

Section: Depletion Of Anp In Af Patients With Atrial Remodelingmentioning

confidence: 99%

Clinical Applications of Natriuretic Peptides in Heart Failure and Atrial Fibrillation

Baba

Yoshida

Ieda

2019

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…The ANP/BNP ratio predicted left atrial reverse remodeling after catheter ablation for persistent AF, and a transient rise in the atrial capture threshold, which is associated with atrial myocardial damage, after implanting a high-voltage device. 42,45 The ANP/BNP ratio has also been shown to be correlated with left atrial fibrosis in the maze procedure. 46 Thus, the ANP/BNP ratio is thought to be a more precise measure for predicting left atrial remodeling than ANP alone.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies also used the ANP/BNP ratio as a clinical marker. The ANP/BNP ratio predicted left atrial reverse remodeling after catheter ablation for persistent AF, and a transient rise in the atrial capture threshold, which is associated with atrial myocardial damage, after implanting a high-voltage device 42,45 . The ANP/BNP ratio has also been shown to be correlated with left atrial fibrosis in the maze procedure 46 .…”

Section: Discussionmentioning

confidence: 99%

Low atrial natriuretic peptide to brain natriuretic peptide ratio is associated with left atrial remodeling

Matsuda

Masuda

Asai

et al. 2023

Journal of Cardiovascular Medicine

View full text Add to dashboard Cite

Aims Atrial natriuretic peptide (ANP) deficiency is thought to be one of the causes of heart failure induced by atrial fibrillation (AF). Although ANP deficiency is thought to occur as a result of atrial remodeling, data to explain this mechanism are limited. The purpose of this study was to investigate the association between ANP and left atrial remodeling or prognosis of heart failure in patients with AF ablation. Methods In total, 373 consecutive patients who underwent initial ablation for persistent AF [age, 67 ± 10 years; female, 97 (26%)] were retrospectively enrolled. ANP and brain natriuretic peptide (BNP) were measured before the procedure and the ANP/BNP ratio was calculated. Left atrial volume index, left atrial appendage emptying velocity, and left atrial low-voltage areas (LVAs) were used as left atrial-remodeling parameters. The primary outcome of heart failure was defined as the composite of all-cause death or hospitalization due to worsening heart failure. Results The median ANP level was 116 (71–178) pg/ml and the median ANP/BNP ratio was 0.65 (0.46–1.00). The ANP/BNP ratio decreased with increasing left atrial volume index or LVAs and with decreasing left atrial appendage emptying velocity. During the 5-year follow-up, freedom from the primary outcome was significantly lower in patients with ANP/BNP ratio ≤0.65 than in those with ANP/BNP ratio >0.65 (84.6% versus 95.6%, P < 0.01). Conclusion Secretion of ANP relative to BNP decreased with progression of left atrial remodeling in patients with AF ablation. Furthermore, prognosis of heart failure was poor in patients with a low ANP/BNP ratio.

show abstract

“…Levels of plasma ANP and BNP were measured within 1 month before catheter ablation. Plasma ANP level was measured with a chemiluminescent enzyme immunoassay (CLEIA), and the BNP level was also measured with a chemiluminescent immunoassay (CLIA) (BML, Inc., Tokyo, Japan) [ 8 , 9 ]. After ablation, these biomarkers were systematically measured annually until recurrence of AF was documented and a redo procedure was performed.…”

Section: Methodsmentioning

confidence: 99%

Predictors of Recurrence after Catheter Ablation of Paroxysmal Atrial Fibrillation in Different Follow-Up Periods

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background and objectives: Pulmonary vein (PV) reconnection is a major reason for recurrence after catheter ablation of paroxysmal atrial fibrillation (PAF). However, the timing of the recurrence varies between patients, and recurrence >1 year after ablation is not uncommon. We sought to elucidate the characteristics of atrial fibrillation (AF) that recurred in different follow-up periods. Materials and Methods: Study subjects comprised 151 consecutive patients undergoing initial catheter ablation of PAF. Left atrial volume index (LAVi) and atrial/brain natriuretic peptide (ANP/BNP) levels were systematically measured annually over 3 years until AF recurred. Results: Study subjects were classified into four groups: non-recurrence group (n = 84), and short-term- (within 1 year) (n = 30), mid-term- (1–3 years) (n = 26), and long-term-recurrence group (>3 years) (n = 11). The short-term-recurrence group was characterized by a higher prevalence of diabetes mellitus (hazard ratio 2.639 (95% confidence interval, 1.174–5.932), p = 0.019 by the Cox method), frequent AF episodes (≥1/week) before ablation (4.038 (1.545–10.557), p = 0.004), and higher BNP level at baseline (per 10 pg/mL) (1.054 (1.029–1.081), p < 0.0001). The mid-term-recurrence group was associated with higher BNP level (1.163 (1.070–1.265), p = 0.0004), larger LAVi (mL/m2) (1.033 (1.007–1.060), p = 0.013), and longer AF cycle length at baseline (per 10 ms) (1.194 (1.058–1.348), p = 0.004). In the long-term-recurrence group, the ANP and BNP levels were low throughout follow-up, as with those in the non-recurrence group, and AF cycle length was shorter (0.694 (0.522–0.924), p = 0.012) than those in the other recurrence groups. Conclusions: Distinct characteristics of AF were found according to the time to first recurrence after PAF ablation. The presence of secondary factors beyond PV reconnections could be considered as mechanisms for the recurrence of PAF in each follow-up period.

show abstract

Mechanistic implication of decreased plasma atrial natriuretic peptide level for transient rise in the atrial capture threshold early after ICD or CRT-D implantation

Abstract: Atrial degenerative change characterized by lower ANP/BNP ratio was associated with the occurrence of TRACT in patients with heart failure. TRVCT could also occur, but it required a longer recovery time than TRACT.

Cited by 3 publications

References 19 publications

Clinical Applications of Natriuretic Peptides in Heart Failure and Atrial Fibrillation

Clinical Applications of Natriuretic Peptides in Heart Failure and Atrial Fibrillation

Low atrial natriuretic peptide to brain natriuretic peptide ratio is associated with left atrial remodeling

Predictors of Recurrence after Catheter Ablation of Paroxysmal Atrial Fibrillation in Different Follow-Up Periods

Contact Info

Product

Resources

About