Mechanistic Insight Antidiabetic Potential of Ursolic Acid: In-Silico Molecular Docking

Abstract

Diabetes mellitus is a chief cause involved in the morbidity and mortality among the global population (Steppan et al., 2001). The main event of this syndrome includes elevated blood glucose level (hyperglycemia) followed by polydipsia and polyuria. The secondary complications include retinal damage, loss of kidney function and damage to nerves. Further, the diabetes mellitus will also increase the cardiovascular disease progression. Pentacyclictriterpenes are as well one of the compounds occurring in plants. In this group Ursolic acid is a well-recognized compound that is accessible from various sources like seeds as well as fruits and possess many types of activities and is a bright contender for developing novel treatment approaches for treating diseases. Thus, in the current study, ursolic acid a triterpenoid was selected for evaluation of antidiabetic potential by molecular docking. A mechanistic insight for their antidiabetic potential is elucidating by interaction of ursolic acid with target proteins.