2019
DOI: 10.3390/ijms21010087
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Mechanistic Insight of Na/K-ATPase Signaling and HO-1 into Models of Obesity and Nonalcoholic Steatohepatitis

Abstract: Obesity is a multifaceted pathophysiological condition that has been associated with lipid accumulation, adipocyte dysfunction, impaired mitochondrial biogenesis and an altered metabolic profile. Redox imbalance and excessive release of inflammatory mediators have been intricately linked in obesity-associated phenotypes. Hence, understanding the mechanisms of redox signaling pathways and molecular targets exacerbating oxidative stress is crucial in improving health outcomes. The activation of Na/K-ATPase/Src s… Show more

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Cited by 7 publications
(5 citation statements)
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References 80 publications
(161 reference statements)
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“…Recent in vitro studies have been able to demonstrate a beneficial role in attenuating biomarkers associated with adipocyte differentiation pathways such as PPARγ and C/EBPβ in 3T3-L1 preadipocyte cells ( Calzadilla et al., 2011 ). The reduction in these biomarkers was shown to be equal to glutathione level elevation through NAC supplementation, reducing ROS, that upregulate the activity of PPARγ and C/EBPβ ( Lee et al., 2009 ; Calzadilla et al., 2011 ; Pratt et al., 2019 ). This allows for speculation that supplementation of NAC during the progression of obesity could reduce adipogenesis through elevation of glutathione level content.…”
Section: Antioxidants In Ameliorating Obesity and Associated Comorbidmentioning
confidence: 99%
“…Recent in vitro studies have been able to demonstrate a beneficial role in attenuating biomarkers associated with adipocyte differentiation pathways such as PPARγ and C/EBPβ in 3T3-L1 preadipocyte cells ( Calzadilla et al., 2011 ). The reduction in these biomarkers was shown to be equal to glutathione level elevation through NAC supplementation, reducing ROS, that upregulate the activity of PPARγ and C/EBPβ ( Lee et al., 2009 ; Calzadilla et al., 2011 ; Pratt et al., 2019 ). This allows for speculation that supplementation of NAC during the progression of obesity could reduce adipogenesis through elevation of glutathione level content.…”
Section: Antioxidants In Ameliorating Obesity and Associated Comorbidmentioning
confidence: 99%
“…In general, the level of HO-1 expression is low when cells are at the resting stage, but profoundly enhanced by certain conditions or stimulators, such as heavy metals, heme, cytokines, hormones, lipid metabolites, and oxygen status [2]. In addition, recent studies have shown that HO-1 is involved in the improvements of several events, such oxidation stress, airway inflammation, functions of adipocytes, obesity, steatohepatitis, atherosclerosis, diabetes mellitus, brain hemorrhage, as well as neuroprotection [3][4][5][6][7][8]. This is especially essential in the health maintenance of the liver which contains about 15% of body heme [9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…It is also found that the administration of EET leads to reduced fatty acid accumulation and improves the status of NAFLD in db/db mice ( 60 ), while inhibition of the antioxidant activity of HO exacerbates hepatic steatosis and fibrosis in hepatic cells ( 61 ). Studies also proved that HO-1 alleviates oxidative stress and reverses the adipocyte phenotype and hepatic steatosis by upregulating SIRT-1 and PPARα ( 62 ). In addition, in diet-induced obese mice with NAFLD, treatment of bilirubin nanoparticles decreased de novo lipogenesis and increased fat-burning β-oxidation ( 63 ).…”
Section: Discussionmentioning
confidence: 99%