Mechanistic insights from the review and evaluation of ayurvedic herbal medicines for the prevention and management of COVID-19 patients

Sarkar, Prasanta Kumar; Mukhopadhyay, Chitrangada Das

doi:10.1016/j.hermed.2022.100554

Cited by 8 publications

(3 citation statements)

References 76 publications

(74 reference statements)

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“…The role of herbal plants, including A. paniculata, as immunity modulators against COVID-19 has attracted a great deal of attention, recently (Das 2022 ; Sarkar and Mukhopadhyay 2022 ). High telomerase activity and short telomeres have been reported in cancer tumours (Piotrowska et al 2005 ), while discoveries on short telomeres and telomerase inhibition have become a target for cancer diagnosis and the development of novel therapeutic agents, in recent years (Nakajima et al 2003 ).…”

Section: Discussionmentioning

confidence: 99%

Andrographis paniculata extract as an immunity modulator against cancer via telomerase inhibition

Valdiani

Ofoghi²,

Akbarizare³

et al. 2022

3 Biotech

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In accordance with the importance of telomerase inhibition as a potential target in cancer therapy, and increasing reports on the association between short telomeres and severe COVID-19 symptoms as well as extensive application of Andrographis paniculata as a remedy for both cancer and SARS-CoV-2, the present study aimed at investigating the impact of the plant’s extracts on telomerase activity (as an important enzyme regulating telomere length). Telomerase inhibition in MCF-7 cells treated with the Dichloromethane, ethanol, water, and methanol extracts of A. paniculata was assessed using Telomerase Repeated Amplification Protocol (TRAP). The above-mentioned extracts inhibited telomerase by 80.3 ± 1.4%, 78.5 ± 1.35%, 77.5 ± 1.81%, and 73.7 ± 1.81%, respectively. Furthermore, the flow cytometry analysis showed that the water and methanol extracts induced higher rates of total apoptosis by 32.8% and 25%, respectively, compared with dichloromethane (10.07%) and ethanol (10.7%) extracts. The inhibitory effect of A. paniculata on telomerase activity can be considered as a potential immunity modulator in cancer therapy; however, telomerase inhibition as a safe approach to SARS-CoV-2 is arguable. Two mechanisms can be considered accordingly; (a) reducing the existing population of short telomeres via telomerase inhibition in cancer cells (arresting proliferation and finally cell death) may decrease the susceptibility against SARS-CoV-2, especially in cancer patients or patients prone to cancer, and (b) increasing the population of short telomeres via telomerase inhibition in normal/somatic cells may increase the susceptibility against SARS-CoV-2. Therefore, the telomerase inhibition of A. paniculata as an immunity modulator in cancer and COVID-19 should be investigated, carefully.

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Section: Discussionmentioning

confidence: 99%

Andrographis paniculata extract as an immunity modulator against cancer via telomerase inhibition

Valdiani

Ofoghi²,

Akbarizare³

et al. 2022

3 Biotech

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“…Mechanistic insights from the review and evaluation of ayurvedic herbal medicines for the prevention and management of COVID-19 patients 34 .…”

Section: Identification Of Phytoconstituents Of Tragia Involucrata Le...mentioning

confidence: 99%

Traditional Kerala Ayurvedic Formulations as a Guideline for the Management of Inflammatory Bowel Disease (IBD) – A Review

Bindu

Menon

2023

JNR

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Inflammatory Bowel Disease (IBD) refers to conditions characterized by the presence of idiopathic intestinal inflammation. The main challenge in the management of IBD is the adverse effects associated with the currently available drugs. Also, not all patients respond completely to the conventional treatments of IBD and its efficacy wanes over time. Thus, the use of complementary and alternative medicine is increasing, as a safer alternative. Certain traditional Ayurveda literature of Kerala describe a condition termed ‘jatara vrana’ (ulcer of the gastrointestinal tract), which, along with its associated clinical features, resembles IBD. Due to the similarity in pathology and presenting features, the line of treatment adopted in the management of jatara vrana may be extended to that of IBD. A close observation of the formulations described in the management of jataravrana described in Chikitsamanjari (a regional Ayurvedic literature of Kerala) reveals that in each formulation individual drugs with varying mechanisms of action, including anti-ulcerative (vranaropana), anti-diarrheal (atisaraghna), anti-inflammatory (sophahara), anti-pyretic (jwarahara) or analgesic (vedanahara) activities, have been logically selected and combined. The active components of some of these drugs have been proven to have various effects in IBD pathology. Though these treatment principles have been used traditionally and Ayurvedic management is promising in many experimental models, it is essential to supplement it with well-designed clinical trials to define the exact role of each of these formulations in the prevention or management of IBD.

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“…Skeletal deformities, reduced growth, and immunological dysfunction can all be caused by riboflavin deficiencies. Dietary supplementation is necessary due to the variable absorption of riboflavin generated from plant sources ( Gharibzahedi et al, 2023 ; Sarkar et al, 2024 ). The growth and resilience of chickens to oxidative stress are influenced by the antioxidant properties of riboflavin and its role in protein synthesis.…”

Section: Introductionmentioning

confidence: 99%

Effects of immersing Japanese quail eggs in various doses of riboflavin on reproductive, growth performance traits, blood indices and economics

Gomaa,

Rashwan,

Tewfik

et al. 2024

Poultry Science

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Mechanistic insights from the review and evaluation of ayurvedic herbal medicines for the prevention and management of COVID-19 patients

Cited by 8 publications

References 76 publications

Andrographis paniculata extract as an immunity modulator against cancer via telomerase inhibition

Andrographis paniculata extract as an immunity modulator against cancer via telomerase inhibition

Traditional Kerala Ayurvedic Formulations as a Guideline for the Management of Inflammatory Bowel Disease (IBD) – A Review

Effects of immersing Japanese quail eggs in various doses of riboflavin on reproductive, growth performance traits, blood indices and economics

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