Mechanistic insights into heat shock protein 27, a potential therapeutic target for cardiovascular diseases

Zou, Yifei; Shi, Henghe; Liu, Ning; Wang, He; Song, Xianjing; Liu, Bin

doi:10.3389/fcvm.2023.1195464

Cited by 9 publications

(3 citation statements)

References 127 publications

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“…HSPB1, HSPB4, and HSPB5 are essential for maintaining the balance of proteins in the eye, and abnormalities in their function are associated with ocular diseases such as cataract [199,200]. Moreover, studies have shown that HSPB1 is involved in the development of cardiovascular diseases by affecting apoptosis, autophagy, oxidative stress, and inflammatory responses [17,201]. The mechanisms through which mutant sHSPs cause disease are complex.…”

Section: Shsps and Diseasementioning

confidence: 99%

Functional Diversity of Mammalian Small Heat Shock Proteins: A Review

Fan

2023

Cells

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The small heat shock proteins (sHSPs), whose molecular weight ranges from 12∼43 kDa, are members of the heat shock protein (HSP) family that are widely found in all organisms. As intracellular stress resistance molecules, sHSPs play an important role in maintaining the homeostasis of the intracellular environment under various stressful conditions. A total of 10 sHSPs have been identified in mammals, sharing conserved α-crystal domains combined with variable N-terminal and C-terminal regions. Unlike large-molecular-weight HSP, sHSPs prevent substrate protein aggregation through an ATP-independent mechanism. In addition to chaperone activity, sHSPs were also shown to suppress apoptosis, ferroptosis, and senescence, promote autophagy, regulate cytoskeletal dynamics, maintain membrane stability, control the direction of cellular differentiation, modulate angiogenesis, and spermatogenesis, as well as attenuate the inflammatory response and reduce oxidative damage. Phosphorylation is the most significant post-translational modification of sHSPs and is usually an indicator of their activation. Furthermore, abnormalities in sHSPs often lead to aggregation of substrate proteins and dysfunction of client proteins, resulting in disease. This paper reviews the various biological functions of sHSPs in mammals, emphasizing the roles of different sHSPs in specific cellular activities. In addition, we discuss the effect of phosphorylation on the function of sHSPs and the association between sHSPs and disease.

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Section: Shsps and Diseasementioning

confidence: 99%

Functional Diversity of Mammalian Small Heat Shock Proteins: A Review

Fan

2023

Cells

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“…HSPs are molecular chaperones that maintain protein stability, facilitate transport, and transmit signals within cells [26][27][28]. HSPs also play a crucial role in protecting cells from stress and preventing the degradation of severely damaged proteins [29,30].…”

Section: Cotreatment With Lr and 43 • C Hyperthermia Suppresses Ht-in...mentioning

confidence: 99%

Enhancing Gastric Cancer Therapeutic Efficacy through Synergistic Cotreatment of Linderae Radix and Hyperthermia in AGS Cells

Ahn,

Baek

2023

Biomedicines

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Gastric cancer remains a global health threat, particularly in Asian countries. Current treatment methods include surgery, chemotherapy, and radiation therapy. However, they all have limitations, such as adverse side effects, tumor resistance, and patient tolerance. Hyperthermia therapy uses heat to selectively target and destroy cancer cells, but it has limited efficacy when used alone. Linderae Radix (LR), a natural compound with thermogenic effects, has the potential to enhance the therapeutic efficacy of hyperthermia treatment. In this study, we investigated the synergistic anticancer effects of cotreatment with LR and 43 °C hyperthermia in AGS gastric cancer cells. The cotreatment inhibited AGS cell proliferation, induced apoptosis, caused cell cycle arrest, suppressed heat-induced heat shock responses, increased reactive oxygen species (ROS) generation, and promoted mitogen-activated protein kinase phosphorylation. N-acetylcysteine pretreatment abolished the apoptotic effect of LR and hyperthermia cotreatment, indicating the crucial role of ROS in mediating the observed anticancer effects. These findings highlight the potential of LR as an adjuvant to hyperthermia therapy for gastric cancer. Further research is needed to validate these findings in vivo, explore the underlying molecular pathways, and optimize treatment protocols for the development of novel and effective therapeutic strategies for patients with gastric cancer.

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“…The RECAST trial demonstrated increased levels of Heat Shock Protein 27 (HSP-27) following RIC [29]. Heat shock protein 27 has been shown to protect against ischaemic injury in pre-clinical models of cardiovascular disease [37]. There is evidence that RIC either reduces or attenuates the rise of S100β in ischaemic stroke [28,29].…”

Section: Introductionmentioning

confidence: 99%

Remote Ischaemic Conditioning for Neurological Disorders – A Systematic Review and Narrative Synthesis

Alhashimi,

Kamarova,

et al. 2024

Preprint

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Introduction: Remote ischaemic conditioning (RIC) refers to the use of controlled transient ischemic and reperfusion cycles, commonly of the upper or lower limb, to mitigate cellular damage from ischaemic injury. Preclinical studies demonstrate that RIC may have a neuroprotective effect and therefore could represent a novel therapeutic option in the management of neurological disorders. The aim of this review is to comprehensively describe the current clinical evidence of RIC in neurological disorders. Methods: A computerised search of EMBASE and OVID MEDLINE was conducted from 2002 to October 2023, for randomised controlled trials (RCTs) investigating RIC in neurological diseases. Results: A total of 46 different RCTs in 12 different neurological disorders (n=7544) were included in the analysis. Conditions included acute ischaemic stroke, symptomatic intracranial stenosis and vascular cognitive impairment. The most commonly used RIC protocol parameters in the selected studies were as follows: cuff pressure at 200mmHg (27 trials), 5-minute cycle length (42 trials), 5 cycles of ischaemia and reperfusion (24 trials), and the application to the upper limb unilaterally (23 trials) . Conclusions: The comprehensive analysis of the included studies reveals promising results regarding the safety and therapeutic effect of RIC as an option for managing neurological diseases. Particularly, the strongest evidence supports its potential use in chronic stroke patients and vascular cognitive impairment. The neuroprotective effects of RIC, as demonstrated in preclinical studies, suggest that this therapeutic approach could extend its benefits to various other diseases affecting the nervous system. However, to establish the efficacy of RIC across different neurological disorders, further trials with larger sample sizes and more diverse patient populations are warranted. Upcoming trials are expected to provide valuable evidence that will not only confirm the efficacy of RIC in neurological disease management but also help identify the most optimal RIC regimen for specific conditions.

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Mechanistic insights into heat shock protein 27, a potential therapeutic target for cardiovascular diseases

Cited by 9 publications

References 127 publications

Functional Diversity of Mammalian Small Heat Shock Proteins: A Review

Functional Diversity of Mammalian Small Heat Shock Proteins: A Review

Enhancing Gastric Cancer Therapeutic Efficacy through Synergistic Cotreatment of Linderae Radix and Hyperthermia in AGS Cells

Remote Ischaemic Conditioning for Neurological Disorders – A Systematic Review and Narrative Synthesis

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