Mechanistic insights into the beneficial effects of curcumin on insulin resistance: Opportunities and challenges

Balakumar, Pitchai; Venkatesan, Kumar; Khan, Noohu Abdulla; Raghavendra, Narasimha; Venugopal, Vijayan; R, Bharathi D; Fuloria, Neeraj Kumar

doi:10.1016/j.drudis.2023.103627

Cited by 5 publications

(1 citation statement)

References 80 publications

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“…The curcuminoids and volatile oil compounds possessed by Curcuma species have been widely studied due to their significant biological activities, their numerous pharmacological effects, including (anti-inflammatory, antitumor, antioxidant, and antimicrobial), their ability to reduce blood glucose levels, and their therapeutic effects on the nervous, digestive and cardiovascular systems ( Anand et al, 2008 ; Kunnumakkara et al, 2008 ; Rathore et al, 2008 ; Lekshmi et al, 2012 ; Gadnayak et al, 2022 ; Alameri et al, 2023 ; Balakumar et al, 2023 ; Erarslan et al, 2023 ; Jabbar et al, 2023 ; Louisa et al, 2023 ; Mohanty et al, 2023 ; Wei et al, 2023 ). Differences in the chemical composition and pharmacological effects of Curcuma species are caused by variations in growth environment, medicinal components, cultivation methods and processing, and a range of other factors.…”

Section: Introductionmentioning

confidence: 99%

Sources, morphology, phytochemistry, pharmacology of Curcumae Longae Rhizoma, Curcumae Radix, and Curcumae Rhizoma: a review of the literature

Zhu,

Quan,

Yin

et al. 2023

Front. Pharmacol.

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Curcumae Longae Rhizoma (turmeric), Curcumae Radix and Curcumae Rhizoma are derived from the Curcuma species, and have gradually become three of the most commonly used medicinal herbs in China due to their different origins, processing methods and medicinal part. These three herbs have certain similarities in morphology, chemical composition, and pharmacological effects. All three of these herbs contain curcuminoids and volatile oil compounds, which exhibit anti-inflammatory, anti-tumor, antioxidant, and neuroprotective properties, although modern clinical applications have their own requirements. At present, there is no systematic guidelines for the clinical application of these three of Curcuma species; consequently, there is a high risk of unwanted phenomena associated with the mixing and indiscriminate use of these herbs. In this review, we focus predominantly on morphology, chemical composition, and the pharmacological activity of these three Curcuma herbs and summarize the current status of research in this field. Our goal is to provide a better understanding of clinical value of these Curcuma species so that we can provide reference guidelines for their further development, utilization and rational clinical application.

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Section: Introductionmentioning

confidence: 99%

Sources, morphology, phytochemistry, pharmacology of Curcumae Longae Rhizoma, Curcumae Radix, and Curcumae Rhizoma: a review of the literature

Zhu,

Quan,

Yin

et al. 2023

Front. Pharmacol.

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Curcumin on Human Health: A Comprehensive Systematic Review and Meta‐Analysis of 103 Randomized Controlled Trials

Jafari,

Abbastabar,

Alaghi

et al. 2024

Phytotherapy Research

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The aim of this meta‐analysis was to determine the effect of curcumin on a range of health outcomes. PubMed, EMBASE, Scopus, and Web of Science were searched from inception until September 2023. Randomized clinical trials (RCTs) that compared the effect of Curcuma longa L. with placebo were considered eligible. The risk of bias and overall certainty of evidence were assessed using the Newcastle‐Ottawa Scale and Grading of Recommendations Assessment, Development, and Evaluation (GRADE), respectively. We meta‐analyzed the effect sizes across eligible studies using the random‐effects model. In total, 103 RCTs on 42 outcomes were included, incorporating a total population of 7216 participants. Overall, 23 out of 42 (55%) outcomes reported statistically significant effect sizes. The credibility of the evidence was rated as high for fasting blood sugar (FBS), C‐reactive protein (CRP), high‐density lipoprotein (HDL), and weight. The remaining outcomes presented moderate (waist circumference [WC], hip circumference [HC], body mass index [BMI], insulin, Homeostatic Model Assessment for Insulin Resistance [HOMA‐IR], quantitative insulin‐sensitivity check index [QUICKI], leptin, gamma‐glutamyl transferase [GGT], glutathione [GSH], and superoxide dismutase [SOD]), low (14 outcomes), or very low (14 outcomes) evidence. In conclusion, curcumin supplementation can modify FBS and some glycemic indices, lipid parameters, as well as inflammatory and oxidative parameters. This updated summary of the accumulated evidence may help inform clinicians and future guidelines regarding medical and scientific interest in curcumin. However, due to limitations in the methodological quality of the included studies, well‐designed and long‐term RCTs with large sample sizes are needed.Trial registration: PROSPERO: CRD42021251969

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Insights into one drug, multi-target aspects of polyphenols for diabetes management: in vitro, in vivo, and clinical evidence

Kannan,

George,

Sahadevan

et al. 2024

Phytochem Rev

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Mechanistic insights into the beneficial effects of curcumin on insulin resistance: Opportunities and challenges

Cited by 5 publications

References 80 publications

Sources, morphology, phytochemistry, pharmacology of Curcumae Longae Rhizoma, Curcumae Radix, and Curcumae Rhizoma: a review of the literature

Sources, morphology, phytochemistry, pharmacology of Curcumae Longae Rhizoma, Curcumae Radix, and Curcumae Rhizoma: a review of the literature

Curcumin on Human Health: A Comprehensive Systematic Review and Meta‐Analysis of 103 Randomized Controlled Trials

Insights into one drug, multi-target aspects of polyphenols for diabetes management: in vitro, in vivo, and clinical evidence

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