Mechanistic insights into the effect of lutein on atherosclerosis, vascular dysfunction, and related risk factors: A systematic review of in vivo, ex vivo and in vitro studies

Hajizadeh-Sharafabad, Fatemeh; Ghoreishi, Zohreh; Maleki, Vahid; Tarighat‐Esfanjani, Ali

doi:10.1016/j.phrs.2019.104477

Cited by 48 publications

(30 citation statements)

References 81 publications

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“…In accordance with the present findings, LTN supplementation reduced plasma ALT and improved hepatic architecture in guinea pigs [78]. In addition, rainbow trout, Oncorhynchus mykiss, fed an LTN supplemented diet showed lower ALT and AST activities and lipid peroxide level in the liver [19]. These improvements of liver function could occur because the liver is the major storage organ for LTN and other carotenoid sources [78].…”

Section: Discussionsupporting

confidence: 90%

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Synergism of Dietary Co-Supplementation with Lutein and Bile Salts Improved the Growth Performance, Carotenoid Content, Antioxidant Capacity, Lipid Metabolism, and Lipase Activity of the Marbled Spinefoot Rabbitfish, Siganus rivulatus

Mansour

El-feky

El-Beltagi

et al. 2020

Animals

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A 60-day feeding trial was conducted to assess the effects of dietary supplementation with bile salts (BS), lutein (LTN), and their combination on growth, survival, carotenoid content, and antioxidant status of rabbitfish (Siganus rivulatus) larvae. Fish were fed four isonitrogenous (34.39% protein) and isoenergetic (20.57 kJ/g) diets supplemented with BS (0.15 g kg−1), LTN (0.1 g kg−1), BS+LTN (0.15 and 0.1 g kg−1, respectively), and a non-supplemented control diet. The results revealed that fish fed BS+LTN had the highest significant specific growth rate (4.37% day−1), feed efficiency (46.55%), and survival (97.78%). Lutein supplementation improved whole-body protein content, meanwhile, fish fed a BS-supplemented diet had a higher lipid content. The carotenoid deposition was significantly increased with LTN and BS+LTN in skin, muscle, and whole body compared to the control and BS treatment. All dietary supplementation of BS and LTN showed significant improvement in total antioxidant capacity, catalase, and glutathione peroxidase activities. Additionally, LTN alone or BS+LTN significantly reduced malondialdehyde levels by 5.30 and 29.91%, respectively compared to the control. BS supplementation modulated aminopeptidases activities, triglycerides, cholesterol, and increased the activity of pancreatic lipase. Therefore, it could be inferred that dietary supplementation with LTN in combination with BS could improve the growth performance, carotenoid deposition, antioxidant status, lipid digestion, and metabolism of S. rivulatus.

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Section: Discussionsupporting

confidence: 90%

“…Purified LTN (yellow-orange crystalline) is classified as generally recognized as safe to be used as a feed supplement [17]. Lutein has higher antioxidant activity than β-carotene [18] and in addition, LTN has anti-atherosclerotic [19], anti-inflammatory [20], and anti-hyperlipidemic effects [21].…”

Section: Introductionmentioning

confidence: 99%

Synergism of Dietary Co-Supplementation with Lutein and Bile Salts Improved the Growth Performance, Carotenoid Content, Antioxidant Capacity, Lipid Metabolism, and Lipase Activity of the Marbled Spinefoot Rabbitfish, Siganus rivulatus

Mansour

El-feky

El-Beltagi

et al. 2020

Animals

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“…In many clinical trials, low levels of plasma lutein were associated with increased risks of atrial fibrillation [ 25 ], atherosclerosis [ 40 ] and hypertension [ 27 ]. Importantly, lutein supplementation significantly decreased the occurrence and development of many cardiovascular diseases [ 41 , 42 ]. Consistent with these findings, our data demonstrated that lutein prevented and reversed Ang II-induced cardiac dysfunction and remodeling by inhibiting ROS production.…”

Section: Discussionmentioning

confidence: 99%

Lutein attenuates angiotensin II- induced cardiac remodeling by inhibiting AP-1/IL-11 signaling

et al. 2021

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Rationale Oxidative stress plays a critical role in the development of cardiac remodeling and heart failure. Lutein, the predominant nonvitamin A carotenoid, has been shown to have profound effects on oxidative stress. However, the effect of lutein on angiotensin II (Ang II)-induced cardiac remodeling and heart failure remains unknown. Objective The aim of this study was to determine whether lutein is involved in cardiac remodeling and to elucidate the underlying molecular mechanisms. Methods and results In vitro experiments with isolated neonatal rat cardiomyocytes (NRCMs) and cardiac fibroblasts (CFs) revealed that lutein significantly attenuated Ang II-induced collagen expression in CFs, and cardiomyocyte hypertrophy. The Ang II-induced increases in superoxide generation, inflammation and apoptosis in cultured CFs were strikingly prevented by lutein. In vivo, fibrosis, hypertrophic cardiomyocyte and superoxide generation were analyzed, and lutein was demonstrated to confer resistance to Ang II-induced cardiac remodeling in mice. Mechanistically, RNA sequencing revealed that interleukin-11 (IL-11) expression was significantly upregulated in mouse hearts in response to Ang II infusion and was significantly suppressed in the hearts of lutein-treated mice. Furthermore, IL-11 overexpression blocked the effects of lutein on fibrosis and oxidative stress in CFs and impaired the protective effect of lutein on cardiac remodeling. Notably, we discovered that lutein could reduce Ang II-induced IL-11 expression, at least partly through the regulation of activator protein (AP)-1 expression and activity. Conclusions Lutein has potential as a treatment for cardiac remodeling and heart failure via the suppression of IL-11 expression.

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“…Another important carotenoid presents in cassava leaves is Lutein, which has an antioxidant potential (Ma & Lin, 2010; Zou et al ., 2011). Carotenoids can also improve immune system function by stimulating lymphocyte production and have preventive effects against cardiovascular diseases (Rodriguez‐Amaya, 2015; Hajizadeh‐Sharafabad et al ., 2019).…”

Section: Introductionmentioning

confidence: 99%

Cyanogenic, carotenoids and protein composition in leaves and roots across seven diverse population found in the world cassava germplasm collection at CIAT, Colombia

Ospina

Pizarro

Tran

et al. 2020

Int J of Food Sci Tech

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Mechanistic insights into the effect of lutein on atherosclerosis, vascular dysfunction, and related risk factors: A systematic review of in vivo, ex vivo and in vitro studies

Cited by 48 publications

References 81 publications

Synergism of Dietary Co-Supplementation with Lutein and Bile Salts Improved the Growth Performance, Carotenoid Content, Antioxidant Capacity, Lipid Metabolism, and Lipase Activity of the Marbled Spinefoot Rabbitfish, Siganus rivulatus

Synergism of Dietary Co-Supplementation with Lutein and Bile Salts Improved the Growth Performance, Carotenoid Content, Antioxidant Capacity, Lipid Metabolism, and Lipase Activity of the Marbled Spinefoot Rabbitfish, Siganus rivulatus

Lutein attenuates angiotensin II- induced cardiac remodeling by inhibiting AP-1/IL-11 signaling

Cyanogenic, carotenoids and protein composition in leaves and roots across seven diverse population found in the world cassava germplasm collection at CIAT, Colombia

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