Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review)

Song, Yiying; Liu, Haiting; Xian, Qingqing; Gui, Chengzhi; Xu, Mingjie; Zhou, Yunying

doi:10.3892/ol.2023.14129

Oncol Lett

2023

DOI: 10.3892/ol.2023.14129

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Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review)

Yiying Song,

Haiting Liu,

Qingqing Xian

et al.

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2024

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Phosphoinositide signaling in the nucleus: Impacts on chromatin and transcription regulation

Hifdi,

Vaucourt,

Hnia

et al. 2024

Biology of the Cell

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Phosphoinositides also called Polyphosphoinositides (PPIns) are small lipid messengers with established key roles in organelle trafficking and cell signaling in response to physiological and environmental inputs. Besides their well‐described functions in the cytoplasm, accumulating evidences pointed to PPIns involvement in transcription and chromatin regulation. Through the description of previous and recent advances of PPIns implication in transcription, this review highlights key discoveries on how PPIns modulate nuclear factors activity and might impact chromatin to modify gene expression. Finally, we discuss how PPIns nuclear and cytosolic metabolisms work jointly in orchestrating key transduction cascades that end in the nucleus to modulate gene expression.

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Phosphoinositide signaling in the nucleus: Impacts on chromatin and transcription regulation

Hifdi,

Vaucourt,

Hnia

et al. 2024

Biology of the Cell

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Mechanistic insights into UHRF1‑mediated DNA methylation by structure‑based functional clarification of UHRF1 domains (Review)

Cited by 1 publication

References 100 publications

Phosphoinositide signaling in the nucleus: Impacts on chromatin and transcription regulation

Phosphoinositide signaling in the nucleus: Impacts on chromatin and transcription regulation

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