Mechanistic insights of soluble uric acid-induced insulin resistance: Insulin signaling and beyond

Yu, Wei; Xie, De; Yamamoto, Tetsuya; Koyama, Hidenori

doi:10.1007/s11154-023-09787-4

Cited by 19 publications

(12 citation statements)

References 168 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relationship between uric acid and diabetes mellitus has been ignored in the past, but with an increase in the incidence of diabetes and hyperuricemia, it has been gradually realized that there may be a relationship between the two. Some studies have shown that uric acid participates in insulin resistance, which increases the rate of diabetes 32 . In a study in South Korea including 4152 healthy volunteers for 7.3 years of follow-up, it was found that a total of 548 volunteers suffered from type 2 diabetes 33 .…”

Section: Discussionmentioning

confidence: 99%

Effect of serum uric acid on prognosis of drug-eluting stent implantation for patients with coronary bifurcated lesions

Gao,

Liu,

Xue

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose To investigate the effect of hyperuricemia on prognosis of drug-eluting stent implantation for patients with coronary bifurcated lesions. Materials and methods Patients with coronary bifurcation lesions treated with drug-eluting stent implantation were retrospectively enrolled. The clinical, interventional and follow-up data were analyzed. Results Totally, 193 patients were enrolled, including 59 with hyperuricemia and 134 without hyperuricemia. Serum triglyceride (1.73 vs. 1.44 mmol/L) and creatinine (70.0 vs. 61.0µmol/L) levels were significantly (P < 0.05) higher in the hyperuricemia than in the non-hyperuricemia group. During follow-up, seven patients died, including one (14.3%) death in the hyperuricemia and six (85.7%) in the non-hyperuricemia group. Twelve patients experienced revascularization, including 5 (41.7%) in the hyperuricemia group and 7 (58.3%) in the non-hyperuricemia group. Seventy patients were readmitted to the hospital because of cardiac reasons, including 36 (51.4%) patients in the hyperuricemia and 34 (48.6%) in the non-hyperuricemia group. The risk of cardiac readmission was significantly (P < 0.001) greater in the non-hyperuricemia than in the hyperuricemia group (30.10 vs. 24.33 m). Age was a significant (P = 0.01) independent risk factor for all-cause mortality after cardiac intervention with a hazard ratio (HR) of 1.12 (95% CI 1.03–1.23). Diabetes mellitus was the only significant (P = 0.007) independent risk factor for revascularization, with a HR of 5.13 (95% CI 1.56–16.91). Male sex (P = 0.023, HR 2.21 with 95% CI of 1.12–4.38), total cholesterol (P = 0.004, HR 2.53 with 95% CI 1.35–4.74), and hyperuricemia (P = 0.001, HR 2.37 with 95% CI 1.44–3.89) were significant independent risk factors for cardiac readmission. Conclusion Hyperuricemia is an independent risk factor for cardiogenic readmission rather than for all-cause mortality and revascularization after drug-eluting stent implantation for patients with coronary bifurcation lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of serum uric acid on prognosis of drug-eluting stent implantation for patients with coronary bifurcated lesions

Gao,

Liu,

Xue

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In addition, PD patients are more prone to metabolic abnormalities, partly due to the high glucose load absorbed from the PD effluent, which further leads to a state of metabolic syndrome and increases susceptibility to PDRP [ 25 ]. Fourth, the TyG index is linked to hyperuricemia [ 26 ], which induces IR [ 27 ], and hyperuricemia can increase the release of inflammatory cytokines and promotes oxidative stress [ 28 , 29 ]. In addition, uric acid was associated with technique failure in patients undergoing PD due to peritonitis [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients

Liu,

Yan,

Wang

et al. 2023

Renal Failure

View full text Add to dashboard Cite

Objective The serum triglyceride-glucose (TyG) index is a marker of inflammation. However, the relationship between TyG index and peritoneal dialysis-related peritonitis (PDRP) is unclear. This study aimed to investigate the potential relationship between the baseline TyG index and the initial episode of PDRP. Methods A total of 208 peritoneal dialysis (PD) patients were enrolled from January 1, 2012, to December 31, 2019 and followed up until December 31, 2022. They were divided into 2 groups according to the median TyG. The primary outcome was the occurrence of the initial episode of PDRP while on PD therapy. Kaplan-Meier curves and Cox regression analyses were used to examine the association between them. Results Eighty-five initial episodes of PDRP were identified. The risk of PDRP was higher in the high-TyG index group ( p = 0.030). Multivariate Cox regression analysis showed a higher risk of PDRP in patients with a high TyG index ( HR = 1.800, 95% CI 1.511–2.815, p = 0.010). Conclusion The baseline serum TyG index was an independent risk factor for the initial episode of PDRP in chronic PD patients.

show abstract

“…Finally, xanthine is oxidized by XO to produce uric acid 4 . When the level of serum uric acid (SUA) exceeds its solubility point of 6.8 mg/dL, it is defined as hyperuricemia, which can be attributed to an excessive production or insufficient excretion of uric acid 5 . In the state of hyperuricemia, urate can crystalize and deposit in joints and soft tissue.…”

Section: Figurementioning

confidence: 99%

“…hyperuricemia, which can be attributed to an excessive production or insufficient excretion of uric acid. 5 In the state of hyperuricemia, urate can crystalize and deposit in joints and soft tissue. SUA levels are influenced by changes in the expression and function of urate transporters in kidney and intestine, especially urate anion transporter 1 (URAT1).…”

mentioning

confidence: 99%

Therapeutic drugs of gout: The progress in target selection

Lin,

Chen,

Lin

2023

Int J of Rheum Dis

View full text Add to dashboard Cite

Therapeutic drugs of gout: The progress in target selectionGout is a chronic, inflammatory, and metabolic disease caused by the deposition of monosodium urate (MSU) crystals. It presents clinically with gout flares, chronic gouty arthritis, and tophi. 1 Gout attacks are often accompanied by various serious complications, such as cardiovascular disease, hypertension, type 2 diabetes, chronic kidney disease, and premature death. 2 With the improvement of living standards and intake of more and more purine-containing foods, gout incidence is increasing yearly. Presently, the incidence rate is 0.58-2.89 per 1000 person-years. 3 Gout has become a severe public health problem, causing great suffering and a heavy financial burden to patients.Gout is caused by purine metabolism disorder and MSU crystals deposition around joints and other tissues. As shown in Figure 1, purine nucleotides are converted to hypoxanthine by purine nucleoside phosphorylase (PNP). Subsequently, hypoxanthine is oxidized to form xanthine by xanthine oxidase (XO). Finally, xanthine is oxidized by XO to produce uric acid. 4 When the level of serum uric acid (SUA) exceeds its solubility point of 6.8 mg/dL, it is defined as

show abstract

Mechanistic insights of soluble uric acid-induced insulin resistance: Insulin signaling and beyond

Cited by 19 publications

References 168 publications

Effect of serum uric acid on prognosis of drug-eluting stent implantation for patients with coronary bifurcated lesions

Effect of serum uric acid on prognosis of drug-eluting stent implantation for patients with coronary bifurcated lesions

Elevated triglyceride-glucose index predisposes to the initial episode of peritonitis in chronic peritoneal dialysis patients

Therapeutic drugs of gout: The progress in target selection

Contact Info

Product

Resources

About