Mechanistic investigation on the toxicity of MgO nanoparticles toward cancer cells

Krishnamoorthy, Karthikeyan; Moon, Jeong Yong; Hyun, Ho Bong; Cho, Somi Kim; Kim, Sang‐Jae

doi:10.1039/c2jm35087d

Cited by 243 publications

(170 citation statements)

References 59 publications

(73 reference statements)

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“…These emission peaks are attributed to the various structural defects, that is, internal stresses, oxygen vacancies, and presence of defects in/on a material surface, which may be produced during the conversion of Mg(OH) 2 into MgO [48,50]. The absence of PL emissions in the bulk MgO is also an evidence of the formation of MgO nanostructures which is consistent with the published results [22,51,52].…”

Section: Resultssupporting

confidence: 81%

“…The luminescence spectrum of MgO (Figure 6(b)) showed multiple peaks around 383, 476, 573, 630, and 666 nm in the visible region [48,50]. These emission peaks are attributed to the various structural defects, that is, internal stresses, oxygen vacancies, and presence of defects in/on a material surface, which may be produced during the conversion of Mg(OH) 2 into MgO [48,50].…”

Section: Resultsmentioning

confidence: 99%

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Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

Akram

Fakhar-e-Alam

Butt

et al. 2018

Journal of Nanomaterials

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The prime focus of this investigation is to determine which morphology of magnesium oxide (MgO) is nontoxic and accumulates in sufficient quantity to a human brain cellular/tissue model. Thus, nanostructured MgO was synthesized from a coprecipitation technique involving twin synthetic protocols and the resulting product was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), size distribution histogram, Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) analysis and elemental composition was confirmed by EDX analysis. They were tested for selective antigen response in a human brain cancer model through biodistribution, biotoxicity via MTT assay, and tissue morphology. In addition, the MRI compatibility of MgO nanostructures and immunofluorescence studies were investigated on nanoconjugates with different immunoglobulins in the brain section. The results indicated that MgO had some degree of bindings with the antigens. These results led to the empirical modeling of MgO nanomaterials towards toxicity in cancer cells by analyzing the statistical data obtained by experiments. All these results are providing new rational strategy with the concept of MgO for MRI and PTT/PDT.

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

Akram

Fakhar-e-Alam

Butt

et al. 2018

Journal of Nanomaterials

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“…Metallic oxides, including silver oxide, copper oxide, titanium dioxide and magnesium oxide (MgO), have attracted attention owing to their high antibacterial activity and broad antibacterial spectrum [11][12][13] . Among them, MgO, and especially nanosized MgO (nMgO), is more promising, considering that it has not only strong antibacterial activity but also excellent biocompatibility, which has been recognized as safe by the US Food and Drug Administration (21CFR184.1431) [14] . Besides, its alkaline degradation products may be in favor of constructing weakly alkaline microenvironments for cellular responses; the magnesium ion is widely involved in human metabolisms, playing an significant role in regulating cellular responses [15] .…”

Section: Introductionmentioning

confidence: 99%

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

Shuai

Guo

Gao

et al. 2024

IJB

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Bone repair failure caused by implant-related infections is a common and troublesome problem. In this study, an antibacterial scaffold was developed via selective laser sintering with incorporating nano magnesium oxide (nMgO) to poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The results indicated the scaffold exerted high antibacterial activity. The antibacterial mechanism was that nMgO could cause oxidative damage and mechanical damage to bacteria through the production of reactive oxygen species (ROS) and direct contact action, respectively, which resulted in the damage of their structures and functions. Besides, nMgO significantly increased the compressive properties of the scaffold including strength and modulus, due to its excellent mechanical properties and uniform dispersion in the PHBV matrix. Moreover, the degradation tests indicated nMgO neutralized the acid degradation products of PHBV and benefited the degradation of the scaffold. The cell culture demonstrated that nMgO promoted the cellular adhesion and proliferation, as well as osteogenic differentiation. The present work may open the door to exploring nMgO as a promising antibacterial material for tissue engineering. Keywords: Nano magnesium oxide; antibacterial scaffolds; degradation properties; cytocompatibility; mechanical properties

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“…The mechanism depends not only on the concentration of NiO NPs, it also depends on sensitivity of bacterial species. The increased antibacterial effect may be due to reactive radicals Ni 2+ ions [42], released continuously in the solution [43], may be attached to the negatively charged bacterial cell wall due to electrostatic force. The strong adhesion of Ni 2+ ions to the bacterial cells causes distraction of cell membrane [44][45][46] and hence antimicrobial efficacy at higher NPs concentration [47].…”

Section: Antibacterial Studiesmentioning

confidence: 99%

Effect of Calcination Time on Structural, Optical and Antimicrobial Properties of Nickel Oxide Nanoparticles

Br¹,

Xr²

2016

J Theor Comput Sci

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Nickel oxide nano crystallites were synthesized using Nickel [II] Chloride and Sodium hydroxide. The Thermo Gravimetric and Differential Thermo gravimetric (TGA/DTA) analysis were done to study the thermal behavior of the as synthesized sample Ni(OH)2. The peak at 290°C in DTA may be related to the decomposition of Ni(OH)2 into NiO. The structural, optical properties, morphology and composition of NiO nano particles (NPs) were studied by various techniques such as XRD, FTIR, UV-Vis, PL, FESEM and EDAX. The antimicrobial activity were carried out against Gram positive and Gram negative bacteria and NiO NPs showed inhibitory activity in both strains of bacteria with excellent selectivity against Gram-positive bacteria.

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Mechanistic investigation on the toxicity of MgO nanoparticles toward cancer cells

Cited by 243 publications

References 59 publications

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

An nMgO containing scaffold: Antibacterial activity, degradation properties and cell responses

Effect of Calcination Time on Structural, Optical and Antimicrobial Properties of Nickel Oxide Nanoparticles

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