Mechanistic modeling of a capsule filling process

Loidolt, Peter; Madlmeir, Stefan; Khinast, Johannes G.

doi:10.1016/j.ijpharm.2017.08.125

Cited by 13 publications

(2 citation statements)

References 25 publications

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“…• Powder dosing: The quality (fill weight and variability) of capsules filled with powder using the dosator nozzle system is greatly influenced by the powder properties and the process settings used during dosing powder from a powder bed [19]. A simulation study by Loidolt et al [20] qualitatively showed the influence of powder properties on the amount of dosed powder during a dosator process using the Discrete Element Method (DEM).…”

Section: Methodsmentioning

confidence: 99%

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

Stranzinger

Markl

Khinast

et al. 2021

TrAC Trends in Analytical Chemistry

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Section: Methodsmentioning

confidence: 99%

Review of sensing technologies for measuring powder density variations during pharmaceutical solid dosage form manufacturing

Stranzinger

Markl

Khinast

et al. 2021

TrAC Trends in Analytical Chemistry

Self Cite

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“…In light of their findings, the ratio of particle size to dosator diameter and powder flowability/cohesiveness were two critical factors that significantly affected powder packing, filling, and compression performance (Table 1). 105 Madlmeir et al also applied DEM simulations to study the impact of dosator geometry and some other process parameters on the filling performance. 106 Notably, particles are modeled as spheres for this above-mentioned exploratory work.…”

Section: Modeling and Simulation Formentioning

confidence: 99%

Emerging Process Modeling Capabilities for Dry Powder Operations for Inhaled Formulations

Lou,

Ding,

et al. 2023

Mol. Pharmaceutics

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Dry powder inhaler (DPI) products are commonly formulated as a mixture of micronized drug particles and large carrier particles, with or without additional fine particle excipients, followed by final powder filling into dose containment systems such as capsules, blisters, or reservoirs. DPI product manufacturing consists of a series of unit operations, including particle size reduction, blending, and filling. This review provides an overview of the relevant critical process parameters used for jet milling, highshear blending, and dosator/drum capsule filling operations across commonly utilized instruments. Further, this review describes the recent achievements regarding the application of empirical and mechanistic models, especially discrete element method (DEM) simulation, in DPI process development. Although to date only limited modeling/simulation work has been accomplished, in the authors' perspective, process design and development are destined to be more modeling/simulation driven with the emphasis on evaluating the impact of material attributes/process parameters on process performance. The advancement of computational power is expected to enable modeling/simulation approaches to tackle more complex problems with better accuracy when dealing with real-world DPI process operations.

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