Mechanistic modelling of drug release from polymer-coated and swelling and dissolving polymer matrix systems

Kaunisto, Erik; Marucci, Mariagrazia; Borgquist, Per; Axelsson, Anders

doi:10.1016/j.ijpharm.2011.01.021

Cited by 117 publications

(48 citation statements)

References 111 publications

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“…[24][25][26][27] Scanning Electron Microscopy (SEM) Images SEM images of fractured surface of PCL and PCL/MMT compounds, non-degraded and immersed in water for 45 days, acquired during impact test, are presented in Figure 9. These surfaces were covered with gold to avoid accumulation of charges.…”

Section: Ray Diffraction (Xrd) Measurementsmentioning

confidence: 99%

Hydrolytic and Thermal Degradation of PCL and PCL/Bentonite Compounds

et al. 2016

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Section: Ray Diffraction (Xrd) Measurementsmentioning

confidence: 99%

Hydrolytic and Thermal Degradation of PCL and PCL/Bentonite Compounds

et al. 2016

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“…7). Of the drug, 80% was released after 8,12, and 20 h with 20, 15, and 10% MS present in the coating layer. As the level of the pore former increased, the membrane became more porous after coming into contact with the aqueous environment, resulting in faster drug release from both the coating layer and the drug layer (11).…”

Section: Effect Of Pore Former Ms Levels On Drug Releasementioning

confidence: 99%

“…Therefore, an initial lag phase is inevitable before the formation of sufficient hydrostatic pressure (7). The lag phase leads to a slow drug onset, especially when the drug has a short biological half-life (8). For this kind of drug, the drug concentration in the blood will decline rapidly over time unless a means is found to provide continued absorption of the drug at a rate that is fast enough to overcome the clearance rate at a therapeutic blood level (9).…”

Section: Introductionmentioning

confidence: 99%

Model Drug as Pore Former for Controlled Release of Water-Soluble Metoprolol Succinate from Ethylcellulose-Coated Pellets Without Lag Phase: Opportunities and Challenges

Wang¹,

Dai²,

Chang

et al. 2014

AAPS PharmSciTech

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Abstract. The objective of the present study was to evaluate the feasibility of using model drug metoprolol succinate (MS) as a pore former to modify the initial lag phase (i.e., a slow or non-release phase in the first 1-2 h) associated with the drug release from coated pellets. MS-layered cores with high drug-layering efficiency (97% w/w) were first prepared by spraying a highly concentrated drug aqueous solution (60% w/w, 70°C) on non-pareils without using other binders. The presence of MS in ethylcellulose (EC) coating solution significantly improved the coating process by reducing pellets sticking, which often occurs during organic coating. There may be a maximum physical compatibility of MS with EC, and the physical state of the drug in the functional coating layer of EC/MS (80:20) was simultaneously crystalline and noncrystalline (amorphous or solid molecule solution). The lag phase associated with hydroxypropylcellulose (HPC) as a pore former was not observed when MS was used as a pore former. The drug release from EC/ MS-coated pellets was pH independent, inversely proportional to the coating levels, and directly related to the pore former levels. The functional coating layer with MS as a pore former was not completely stabilized without curing. Curing at 60°C for 1 day could substantially improve the stability of EC/MScoated pellets. The physical state of the drug in the free film of EC/MS (85:15) changed partially from amorphous to crystal when cured at 60°C for 1 day, which should be attributed to the incompatibility of the drug with EC.

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“…In this section, the basic models are described. The interested reader is encouraged to consult the many reviews available in the literature for more detail [14,[19][20][21][23][24][25][26][27][28][29][30][31][32][33].…”

Section: Modeling Drug Releasementioning

confidence: 99%