2018
DOI: 10.1096/fasebj.2018.32.1_supplement.531.11
|View full text |Cite
|
Sign up to set email alerts
|

Mechanistic Studies of Drug‐Like Inhibitors of P‐glycoprotein using ATPase Assays, Electron Spin Resonance Spectroscopy and Cancer Cell Models

Abstract: Multidrug resistance (MDR) in cancer and other diseases is frequently associated with transmembrane efflux proteins, one of which is P‐glycoprotein (P‐gp). Over‐expression of P‐gp in cancer cells increases the efflux of therapeutic drugs rendering them ineffective. In order to re‐sensitize multidrug resistant cancers to chemotherapy, we have found inhibitors of P‐gp by in silico screening methods (Brewer et al., Molecular pharmacology 86, 716–726, 2014), and several of these inhibitors were shown to successful… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 66 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?