Mechanistic studies of MALAT1 in respiratory diseases

Wu, Wenzheng; Wang, Shihao; Zhang, Lu; Mao, Beibei; Wang, Bin; Wang, Xiaoxu; Zhao, Dongsheng; Zhao, Peng; Mou, Yunying; Yan, Ping

doi:10.3389/fmolb.2022.1031861

Cited by 11 publications

(7 citation statements)

References 105 publications

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“…It has been reported that MALAT1 is related to cancer cell proliferation, inflammation, metastasis, fibroblast proliferation, and endothelial cell proliferation. 30 MALAT1 aggravates inflammation through modulating NF-κB and regulate airway epithelial cells to secrete IL-8 in pneumonia. 31 In our study, genes of NFKB1 and CXCL8 were expressed in MALAT1 + epithelial cells (Supplementary Fig.…”

Section: Epithelial Cells Expressed Sasp and Upregulated Inflammatory...mentioning

confidence: 99%

scRNA-Seq: First Atlas and Cellular Landscape of Lacrimal Sac: Implications in Primary Acquired Nasolacrimal Duct Obstruction Pathogenesis

Zhang,

Huang,

Liu

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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The aim of this study was to describe the transcriptional changes of individual cellular components in the lacrimal sac in patients with primary acquired nasolacrimal duct obstruction (PANDO) and attempt to construct the first lacrimal sac cellular atlas to elucidate the potential mechanisms that may drive the disease pathogenesis. METHODS.Lacrimal sac samples were obtained intra-operatively during the endoscopic dacryocystorhinostomy (EnDCR) procedure from five patients. Single-cell RNA sequencing was performed to analyze each individual cell population including epithelial and immune cells during the early inflammatory and late inflammatory phases of the disease. RESULTS.Eleven cell types were identified among 25,791 cells. T cells and B cells were the cell populations with the greatest variation in cell numbers between the two phases and were involved in immune response and epithelium migration-related pathways. The present study showed that epithelial cells highly expressed the genes of senescenceassociated secretory phenotype (SASP) and were involved in influencing the inflammation, neutrophil chemotaxis, and migration during the late inflammatory stage. Enhanced activity of CXCLs-CXCRs between the epithelial cells and neutrophils was noted by the cell-cell communication analysis and is suspected to play a role in inflammation by recruiting more neutrophils. CONCLUSIONS.The study presents a comprehensive single-cell landscape of the lacrimal sac cells in different phases of PANDO. The contribution of T cells, B cells, and epithelial cells to the inflammatory response, and construction of the intercellular signaling networks between the cells within the lacrimal sac has further enhanced the present understanding of the PANDO pathogenesis.

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Section: Epithelial Cells Expressed Sasp and Upregulated Inflammatory...mentioning

confidence: 99%

scRNA-Seq: First Atlas and Cellular Landscape of Lacrimal Sac: Implications in Primary Acquired Nasolacrimal Duct Obstruction Pathogenesis

Zhang,

Huang,

Liu

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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“…MALAT1 can worsen ALI conditions by interacting with different miRNAs [ 85 ]. MALAT1 can downregulate specific miRNAs and can ultimately facilitate the pathogenesis of ALI [ 86 ].…”

Section: Lncrnas In Ali/ardsmentioning

confidence: 99%

Long Noncoding RNA: A Novel Insight into the Pathogenesis of Acute Lung Injury

Dutta

Zhu²,

Han³

et al. 2023

JCM

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Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), represent an acute stage of lung inflammation where the alveolar epithelium loses its functionality. ALI has a devastating impact on the population as it not only has a high rate of incidence, but also has high rates of morbidity and mortality. Due to the involvement of multiple factors, the pathogenesis of ALI is complex and is not fully understood yet. Long noncoding RNAs (lncRNAs) are a group of non-protein-coding transcripts longer than 200 nucleotides. Growing evidence has shown that lncRNAs have a decisive role in the pathogenesis of ALI. LncRNAs can either promote or hinder the development of ALI in various cell types in the lungs. Mechanistically, current studies have found that lncRNAs play crucial roles in the pathogenesis of ALI via the regulation of small RNAs (e.g., microRNAs) or downstream proteins. Undoubtedly, lncRNAs not only have the potential to reveal the underlying mechanisms of ALI pathogenesis but also serve as diagnostic and therapeutic targets for the therapy of ALI.

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“…Numerous studies based on bioassays have identified changes in NEAT1 and MALAT1 expression in COVID-19 that have been associated with viral replication [ 129 , 130 ]. For example, the change in MALAT1 expression found in patients with COVID-19 was previously considered to be a regulator of the expression of a gene encoding markers of lung cancer metastasis, and its deletion led to the activation of P53 and its target genes that affect the normal cell cycle [ 131 ]. However, recent studies have shown that MALAT1 can reduce epigenetic silencing of viral transcription by regulating promoter-enhancer interaction to promote viral transcription and infection [ 132 ].…”

Section: Non-coding Rnas In Covid-19mentioning

confidence: 99%