Mechanistic studies on the release of lysozyme from twin-screw extruded lipid implants

Sax, Gerhard; Winter, Gerhard

doi:10.1016/j.jconrel.2012.08.025

Cited by 21 publications

(7 citation statements)

References 31 publications

(43 reference statements)

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“…4) before. This statement is supported by release measurements in tsc-extrudates with lysozyme [32], which is a protein with similar properties compared to IFNα. In these measurements the release profiles of the protein at temperatures where H12 was molten showed a similar slow down of the release rate after the linear regime, whereas incubation at temperatures where H12 was still solid lead to a linear correlation over the complete time range and showed no slow down of the release rate.…”

Section: Diffusion Pathways Of Fluo-ifnα Molecules In Tsc-extrudatesmentioning

confidence: 60%

Release pathways of interferon α2a molecules from lipid twin screw extrudates revealed by single molecule fluorescence microscopy

Sax

Feil

Schulze

et al. 2012

Journal of Controlled Release

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Section: Diffusion Pathways Of Fluo-ifnα Molecules In Tsc-extrudatesmentioning

confidence: 60%

Release pathways of interferon α2a molecules from lipid twin screw extrudates revealed by single molecule fluorescence microscopy

Sax

Feil

Schulze

et al. 2012

Journal of Controlled Release

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“…Glyceryl tristearate was selected for its physicochemical characteristics and thermal properties (44,45), being a hard fat with a melting range of 60-73°C, that remains intact when reaching the body temperature. Moreover, due to its biocompatibility and biodegradability, it has already been proposed for formulation of lipid implants (46). By this way, unidirectional release and penetration via the buccal mucosa were provided while folding endurance of films remains satisfactory.…”

Section: Discussionmentioning

confidence: 99%

Mucoadhesive Polymeric Films to Enhance Barbaloin Penetration Into Buccal Mucosa: a Novel Approach to Chemoprevention

Prima

Conigliaro

2019

AAPS PharmSciTech

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Nowadays, chemoprevention by administering natural supplements is considered an attractive strategy to reverse, suppress, or prevent the evolution of premalignant oral lesions. In particular, Barbaloin exhibits anti-proliferative, anti-inflammatory, and anti-cancer properties, and it results useful in multi-therapy with classic chemotherapeutics. Therefore, in this work, mucoadhesive buccal films, as locoregional drug delivery system able to provide a targeted and efficient therapeutic delivery of Barbaloin, are proposed. Thus, Aloin extractloaded Eudragit® RL100 or Eudragit® RS100-based buccal films were designed in order to obtain an easily self-administrable formulation capable of promoting Barbaloin penetration into buccal mucosa and assuring high patient compliance. Large amounts of extract (44%) were loaded into the polymer matrix and six formulations were prepared varying polymers and plasticizers ratios. For all formulations, physical form (thermogravimetric analysisdifferential scanning calorimetry, TGA-DSC), swelling degree, mucoadhesiveness, drug release, and ability to promote drug penetration in mucosa have been investigated. After a sequential selection process, Eudragit RS 100-based film, with low PVP and high plasticizers amounts, emerged as the most promising. It results appropriately flexible, uniform in terms of weight, thickness and drug content, as well as characterized by suitable surface pH, good mucoadhesiveness, and low swelling degree. It displays a Higuchian drug release behavior up to 89% of Barbaloin released, thus demonstrating that diffusion through the matrix is the main release mechanism. Remarkable penetration enhancer properties of film were demonstrated by evidence of Barbaloin accumulation into buccal mucosa up to 10-fold higher than those obtained following administration of Aloin solution.

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“…Carriers used in HME can be either polymers or lipids. Polymeric materials can be either biodegradable or nonbiodegradable [25] and will be further addressed in this review. To be extrudable, the polymer must exhibit thermoplastic characteristics next to its thermal stability in the required extrusion temperature range.…”

Section: Polymers Used In Hmementioning

confidence: 99%

Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization

Stanković

Frijlink

Hinrichs

2015

Drug Discovery Today

107

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Mechanistic studies on the release of lysozyme from twin-screw extruded lipid implants

Cited by 21 publications

References 31 publications

Release pathways of interferon α2a molecules from lipid twin screw extrudates revealed by single molecule fluorescence microscopy

Release pathways of interferon α2a molecules from lipid twin screw extrudates revealed by single molecule fluorescence microscopy

Mucoadhesive Polymeric Films to Enhance Barbaloin Penetration Into Buccal Mucosa: a Novel Approach to Chemoprevention

Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization

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