2013
DOI: 10.1021/bi400209z
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Mechanistic Studies Unravel the Complexity Inherent in Tau Aggregation Leading to Alzheimer’s Disease and the Tauopathies

Abstract: The aggregation of the protein tau into amyloid fibrils is known to be involved in the causation of the neurodegenerative tauopathies and the progression of cognitive decline in Alzheimer's disease. This review surveys the mechanism of tau aggregation with special emphasis on the information obtained from biochemical and biophysical studies. First, tau is described from a structure-function perspective. Subsequently, the connection of tau to neurodegeneration is explained, and a description of the tau amyloid … Show more

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Cited by 51 publications
(61 citation statements)
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References 215 publications
(517 reference statements)
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“…In vitro , formation of oligomers and higher order polymers of tau is thought to occur through the process of nucleation, elongation, and/or autocatalytic growth [60,61]. Regulatory pathways may influence the availability of free tau, its phosphorylation state, propensity to aggregate, and inducers of aggregation.…”
Section: Discussionmentioning
confidence: 99%
“…In vitro , formation of oligomers and higher order polymers of tau is thought to occur through the process of nucleation, elongation, and/or autocatalytic growth [60,61]. Regulatory pathways may influence the availability of free tau, its phosphorylation state, propensity to aggregate, and inducers of aggregation.…”
Section: Discussionmentioning
confidence: 99%
“…The carboxy-terminal part of tau inhibits fibrils formation and subsequently its cleavage enhances tau propensity to aggregate (Abraha et al, 2000;Berry et al, 2003). Tau forms fibrils through a non-classical nucleation dependent mechanism (Ramachandran and Udgaonkar, 2013). Given its hydrophilic nature, tau does not spontaneously form fibrils in solution at ''cellular'' concentrations (micromolar range) since its solubility is much higher (millimolar range) (Crowther et al, 1994;Binder, 1995, 1997).…”
Section: Involvement In Disease Processmentioning
confidence: 99%
“…In these images, another class of filament is often seen in regions occupied by PHFs, namely cylindrical filaments with periodic thin regions (CF-PT) also labelled “straight filaments”. 6 CF-PT bears a close resemblance to PHFs, sharing the same turn period; however, CF-PT has a smaller radial variance than PHFs with larger thin regions and smaller wide regions. In addition, upon sonication, it has been observed that a mixed population of CF-PT and PHFs is converted into one wholly composed of PHFs.…”
Section: Introductionmentioning
confidence: 91%