Mechanistic Study of Release Characteristics of Two Active Ingredients in Transdermal Patch Containing Lidocaine−Flurbiprofen Ionic Liquid

Yang, Degong; Chen, Xuejun; Li, Ziqing; Yang, Chunrong

doi:10.3390/pharmaceutics14102158

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…They found that release amounts of two drugs of API-ILs in four PSAs were all significantly different, proving that the two components were not released synchronously. This was because PSAs participated in inter-ionic interaction with the API-ILs and reduced the release of drugs [44] .…”

Section: Roles and Mechanismsmentioning

confidence: 99%

Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges

Chen,

Li,

Yang

et al. 2024

Asian Journal of Pharmaceutical Sciences

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Section: Roles and Mechanismsmentioning

confidence: 99%

Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges

Chen,

Li,

Yang

et al. 2024

Asian Journal of Pharmaceutical Sciences

Self Cite

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“…Furthermore, the adsorption of lidocaine onto cellulose is governed by Coulombic forces between the positively charged lidocaine molecules and the negatively charged cellulose surface. In aqueous environments, the ionized hydroxyl groups on cellulose create negatively charged sites, attracting the positively charged lidocaine molecules [85]. These electrostatic interactions, play a significant role in facilitating the adsorption of lidocaine onto BC, further enhancing its EE.…”

Section: Assessment Of Lidocaine Incorporation and Releasementioning

confidence: 99%

Synthesis of Transparent Bacterial Cellulose Films as a Platform for Targeted Drug Delivery in Wound Care

Amorim,

Cavalcanti,

Medeiros

et al. 2024

Processes

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Bacterial cellulose (BC) can be chemically modified and combined with other materials to create composites with enhanced properties. In the medical field, biomaterials offer advantages, such as biocompatibility and sustainability, enabling improved therapeutic strategies and patient outcomes. Incorporating lidocaine into wound dressings offers significant potential benefits. In this study, transparent BC films were produced in situ with an undefined minimal culture medium with a yeast and bacteria co-culture system on black tea (Camellia sinensis) and white sugar medium for three days. Lidocaine was incorporated ex situ into the BC matrix, and the composite film was sterilized using gamma radiation. Drug-release studies showed a two-stage release profile, with an initial fast release (24.6%) followed by a slower secondary release (27.2% cumulative release). The results confirmed the incorporation of lidocaine into the BC, producing highly transparent films with excellent thermal stability, essential for the storage and transportation of wound dressings. This study highlighted BC properties and drug incorporation and release behavior. The findings contribute towards optimizing wound dressings with controlled drug release, showcasing the potential of transparent BC films as an effective platform for wound care and drug-delivery applications.

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“…A study showed that ionic fluids are safe, contribute to the increase in skin permeability and are promising applications in the field of transdermal systems used in pain treatment [60].…”

Section: Transdermal System With Flurbiprofen and Lidocaine-ionic Liq...mentioning

confidence: 99%

Strategies for Improving Transdermal Administration: New Approaches to Controlled Drug Release

et al. 2023

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In this work, we aim to address several strategies to improve transdermal drug delivery, such as iontophoresis, sonophoresis, electroporation and micron. We also propose a review of some transdermal patches and their applications in medicine. TDDs (transdermal patches with delayed active substances) are multilayered pharmaceutical preparations that may contain one or more active substances, of which, systemic absorption is achieved through intact skin. The paper also presents new approaches to the controlled release of drugs: niosomes, microemulsions, transfersomes, ethosomes, but also hybrid approaches nanoemulsions and microns. The novelty of this review lies in the presentation of strategies to improve the transdermal administration of drugs, combined with their applications in medicine, in light of pharmaceutical technological developments.

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Mechanistic Study of Release Characteristics of Two Active Ingredients in Transdermal Patch Containing Lidocaine−Flurbiprofen Ionic Liquid

Cited by 5 publications

References 38 publications

Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges

Ionic liquids as the effective technology for enhancing transdermal drug delivery: Design principles, roles, mechanisms, and future challenges

Synthesis of Transparent Bacterial Cellulose Films as a Platform for Targeted Drug Delivery in Wound Care

Strategies for Improving Transdermal Administration: New Approaches to Controlled Drug Release

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