Mechano-bactericidal anisotropic particles for oral biofilm treatment

Protasiuk, L E; Serov, Nikita; Lokteva, Alina V; Kladko, Daniil V.; Koshel, Elena I.; Vinogradov, Vladimir V.

doi:10.1039/d2tb00582d

Cited by 1 publication

(1 citation statement)

References 54 publications

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“…There is a strong need for an alternative methodology to address catheter-associated infections, which could be found in mechanical-force-based concepts to eliminate biofilm. In addition to passive bacteria killing via bactericidal cicada-like surfaces and particles, − magnetically controlled micro- and nanoparticles have garnered much attention . Generally, a magnetic field is a noninvasive and biologically safe approach that provides an interesting opportunity to bring thermal or mechanical stimuli through a magnetic particle .…”

Section: Introductionmentioning

confidence: 99%

Magnetic Soft Robot for Minimally Invasive Urethral Catheter Biofilm Eradication

Baburova,

Kladko,

Lokteva

et al. 2023

ACS Nano

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Catheter-related biofilm infection remains the main problem for millions of people annually, affecting morbidity, mortality, and quality of life. Despite the recent advances in the prevention of biofilm formation, alternative methods for biofilm prevention or eradication still should be found to avoid traumatic and expensive removal or catheter replacement. Soft magnetic robots have drawn significant interest in favor of remote control, fast response, and wide space for design. In this work, we demonstrated magnetic soft robots as a minimally invasive, safe, and effective approach to eliminate biofilm from urethral catheters (20 Fr or 5.1 mm in diameter). Seven designs of the robot were fabricated (size 4.5 × 15 mm), characterized, and tested in the presence of a rotating magnetic field. As a proof-of-concept, we demonstrated the superior efficiency of biofilm removal on the model of a urethral catheter using a magnetic robot, reaching full eradication for the octagram-shaped robot (velocity 2.88 ± 0.6 mm/s) at a 15 Hz frequency and a 10 mT amplitude. These findings are helpful for the treatment of biofilm-associated catheter contamination, which allows an increase in the catheter wearing time without frequent replacement and treatment of catheter-associated infections.

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