Mechano-growth factor E peptide promotes healing of rat injured tendon

Zhang, Bingyu; Luo, Qing; Kuang, Dongdong; Ju, Yang; Song, Guanbin

doi:10.1007/s10529-016-2162-8

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…MGF injection was reported as a reliable therapeutic method in an in vivo study, where Deng et al injected 28.5-and 57-μg/kg body weight MGF into the bone deflection area of rabbits to promote osteogenesis and demonstrated that high-dose MGF treatment is more effective in bone repair than low-dose treatment. Zhang et al injected MGF into the ankle joints of rats for tendon repair and reported that 1-μg/ml-MGF treatment had a superior result (Zhang, Luo, Chen, et al, 2016;Zhang, Luo, Kuang, Ju, & Song, 2016). In the present study, three different MGF treatment doses (0.1-10 μg/ml) were used for OA cartilage repair.…”

Section: Discussionmentioning

confidence: 73%

The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis

Song

et al. 2017

J Tissue Eng Regen Med

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Previous studies have attached more importance to growth factors in treating cartilage degeneration and osteoarthritis (OA). Here, the capability of mechano growth factor-C24E (MGF) to prevent osteoarthritic cartilage degeneration was evaluated in vitro and in vivo. Using in vitro cultured human OA chondrocytes treated with 10-60-ng/ml MGF for 12 hr, we detected the cell proliferation, migration, and anabolism of OA chondrocytes. The unfolded protein response and the protein characteristic of OA pathology, such as transforming growth factor β, SMAD family member 3, and hypoxia-inducible factor 2α of OA chondrocytes, were also detected by western blotting. Furthermore, protein kinase RNA-like endoplasmic reticulum kinase was knocked down via small interfering RNA to illuminate the potential mechanism of MGF's treatment of OA. In a rabbit knee joint OA model, cartilage degeneration was inhibited after 2 weeks of treatment with 0.1-10-μg/ml MGF. This study demonstrated that MGF treatment can inhibit the pathological apoptosis of OA chondrocytes and promote the proliferation, migration, and matrix synthesis of the chondrocytes. The results also demonstrate that the degeneration of OA cartilage can be delayed by MGF treatment partially via unfolded protein response regulated by protein kinase RNA-like endoplasmic reticulum kinase and suggest a potential therapeutic application of MGF for OA treatment.

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Section: Discussionmentioning

confidence: 73%

The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis

Song

et al. 2017

J Tissue Eng Regen Med

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“…Healing/migratory percentages were estimated compared to t0 of the respective cell type using the formula: 100-(area in t16 or t30 or t48 / area in t0) ×100. Respective p-values were generated comparing the differences in healing in the same time points (16,30…”

Section: Cell Cultures Treatments and Stable Transfectionsmentioning

confidence: 99%

The COOH-terminus of the IGF-1Ec Isoform Enhances the Proliferation and Migration of Human MCF-7 Breast Cancer Cells

Christopoulos

Papageorgiou

Petraki

et al. 2017

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“…MGF is a growth factor that was first identified in mechanically stimulated skeletal muscle 10,11 . Subsequently, MGF was found in many other tissues, such as ischemic tissue of brain, 12 stromal cells of the eutopic endometrium, 13 malignancies, 14 osteoblasts, 15 growth plate chondrocytes 16 et al Studies have confirmed that MGF is involved in the repair and regeneration process of muscles, 17 bones, 18 nerves, 19 tendons, 20 cartilage, 16 and many other tissues and organs under biomechanical environments after damage. It even showed outstanding performance in enhancing skeletal muscle movement 21 .…”

Section: Introductionmentioning

confidence: 99%

Mechanochemical coupling of MGF mediates periodontal regeneration

Zhao,

Zhang,

Cheng

et al. 2023

Bioengineering & Transla Med

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Clinical evidence shows that the mechanical stimulation obtained from occlusion could enhance periodontal ligament (PDL) remodeling. Mechano‐growth factor (MGF) is a growth factor produced specifically following mechanical stimulus Here, we aim to investigate the mechanical enhancement potential and mechanism of the MGF in PDL regeneration. In vivo study found that MGF produced from the PDL under occlusion force could strongly enhance PDL remodeling. In vitro experiments and mathematical modeling further confirmed the mechanical enhancement effect of MGF for PDLSC differentiation toward fibroblasts. A mechanochemical coupling effect of MGF mediated the enhancement of mechanical effect, which was modulated by Fyn‐FAK kinases signaling and subsequent MAPK pathway. Finally, enhanced PDL regeneration under the mechanochemical coupling of MGF and occlusal force was verified in vivo. There exists an additive mechanical effect of MGF mediated by Fyn‐FAK crosstalk and subsequent ERK1/2 and p38 phosphorylation, which could be developed as an MGF‐centered adjuvant treatment to optimize PDL remodeling, especially for patients with weakened bite force or destroyed periodontium.

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Mechano-growth factor E peptide promotes healing of rat injured tendon

Abstract: MGF-C25E plays an important role in promoting healing of injured rat tendon and could be used as a potential therapeutic factor for tendon repair.

Cited by 8 publications

References 20 publications

The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis

The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis

The COOH-terminus of the IGF-1Ec Isoform Enhances the Proliferation and Migration of Human MCF-7 Breast Cancer Cells

Mechanochemical coupling of MGF mediates periodontal regeneration

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