Mechano-regulation of collagen biosynthesis in periodontal ligament

Kaku, Masaru; Yamauchi, Mitsuo

doi:10.1016/j.jpor.2014.08.003

Cited by 76 publications

(74 citation statements)

References 170 publications

(195 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A number of unique collagen-modifying enzymes and molecular chaperones are involved in these processes [46,47]. Various factors affect post-translational modifications of type I collagen, including aging [48], systemic diseases (e.g., osteoporosis, osteopetrosis, OI, and diabetes) [32,49], and mechanical stress [50][51][52][53][54].…”

Section: Post-translational Modifications Of Type I Collagenmentioning

confidence: 99%

A paradigm shift for bone quality in dentistry: A literature review

Kuroshima

Kaku

Ishimoto

et al. 2017

Journal of Prosthodontic Research

Self Cite

View full text Add to dashboard Cite

A B S T R A C TPurpose: The aim of this study was to present the current concept of bone quality based on the proposal by the National Institutes of Health (NIH) and some of the cellular and molecular factors that affect bone quality. Study selection: This is a literature review which focuses on collagen, biological apatite (BAp), and bone cells such as osteoblasts and osteocytes. Results: In dentistry, the term "bone quality" has long been considered to be synonymous with bone mineral density (BMD) based on radiographic and sensible evaluations. In 2000, the NIH proposed the concept of bone quality as "the sum of all characteristics of bone that influence the bone's resistance to fracture," which is completely independent of BMD. The NIH defines bone quality as comprising bone architecture, bone turnover, bone mineralization, and micro-damage accumulation. Moreover, our investigations have demonstrated that BAp, collagen, and bone cells such as osteoblasts and osteocytes play essential roles in controlling the current concept of bone quality in bone around hip and dental implants. Conclusion: The current concept of bone quality is crucial for understanding bone mechanical functions. BAp, collagen and osteocytes are the main factors affecting bone quality. Moreover, mechanical loading dynamically adapts bone quality. Understanding the current concept of bone quality is required in dentistry.

show abstract

Section: Post-translational Modifications Of Type I Collagenmentioning

confidence: 99%

A paradigm shift for bone quality in dentistry: A literature review

Kuroshima

Kaku

Ishimoto

et al. 2017

Journal of Prosthodontic Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Fibroblasts are the main cells in the PDL, which form, maintain, and repair the alveolar bone and cementum. In addition, sensors in the PDL provide proprioceptive input and detect pressure applied to the teeth 123. The morphology of the PDL varies in terms of tooth anatomy and even tooth surface.…”

Section: Introductionmentioning

confidence: 99%

Review of common conditions associated with periodontal ligament widening

Mortazavi

Baharvand

2016

Imaging Sci Dent

View full text Add to dashboard Cite

PurposeThe aim of this article is to review a group of lesions associated with periodontal ligament (PDL) widening.Materials and MethodsAn electronic search was performed using specialized databases such as Google Scholar, PubMed, PubMed Central, Science Direct, and Scopus to find relevant studies by using keywords such as “periodontium”, “periodontal ligament”, “periodontal ligament space”, “widened periodontal ligament”, and “periodontal ligament widening”.ResultsOut of nearly 200 articles, about 60 were broadly relevant to the topic. Ultimately, 47 articles closely related to the topic of interest were reviewed. When the relevant data were compiled, the following 10 entities were identified: occlusal/orthodontic trauma, periodontal disease/periodontitis, pulpo-periapical lesions, osteosarcoma, chondrosarcoma, non-Hodgkin lymphoma, progressive systemic sclerosis, radiation-induced bone defect, bisphosphonate-related osteonecrosis, and osteomyelitis.ConclusionAlthough PDL widening may be encountered by many dentists during their routine daily procedures, the clinician should consider some serious related conditions as well.

show abstract

“…For example, the degree and combination of Lys hydroxylation and glycosylation (galactosyl‐ or glucosyl‐galactosyl‐) will have a significant influence on defining the intermolecular cross‐links that form and determine the structural and mechanical properties of the tissue. In higher mammals, the helical collagen cross‐linking lysines are similarly modified in PDL and other ligaments . Higher levels of modified Lys were identified in the C‐telopeptide cross‐linking site of mouse (85%) than human (50%).…”

Section: Discussionmentioning

confidence: 99%

“…Periodontal ligament (PDL) is a highly specialized connective tissue that suspends individual teeth within the alveolar bone. PDL has several biological functions including tooth support, regulating tooth eruption, dissipating masticatory forces and facilitating the movement of teeth through the alveolar bone when under orthodontic force . Periodontal disease is a chronic inflammatory disorder of the periodontium that affects 46% of the US population and may progress to tooth loss .…”

Section: Introductionmentioning

confidence: 99%

Distinct post‐translational features of type I collagen are conserved in mouse and human periodontal ligament

Hudson

Garibov

Dixon

et al. 2017

J of Periodontal Research

View full text Add to dashboard Cite

Objectives Specifics of the biochemical pathways that modulate collagen cross-links in the periodontal ligament (PDL) are not fully defined. Better knowledge of the collagen post-translational modifications that give PDL its distinct tissue properties is needed to understand the pathogenic mechanisms of human PDL destruction in periodontal disease. In this study the post-translational phenotypes of human and mouse PDL type I collagen were surveyed using mass spectrometry. Background PDL is a highly specialized connective tissue that joins tooth cementum to alveolar bone. The main function of the PDL is to support the tooth within the alveolar bone while under occlusal load after tooth eruption. Almost half of the adult population in the US suffers from periodontal disease resulting from inflammatory destruction of the PDL, leading to tooth loss. Interestingly, PDL is unique from other ligamentous connective tissues as it has a high rate of turnover. Rapid turnover is believed to be an important characteristic in order for this specialized ligament to function within the oral-microbial environment. Like other ligaments, PDL is composed predominantly of type I collagen. Collagen synthesis is a complex process with multiple steps and numerous post-translational modifications including hydroxylation, glycosylation, and cross-linking. The chemistry, placement and quantity of intermolecular cross-links are believed to be important regulators of tissue-specific structural and mechanical properties of collagens. Methods Type I collagen was isolated from several mouse and human tissues, including PDL, and analyzed by mass spectrometry for post-translational variances. Results The collagen telopeptide cross-linking lysines of PDL were found to be partially hydroxylated in human and mouse, as well as in other types of ligament. However, the degree of hydroxylation and glycosylation at the helical Lys87 cross-linking residue varied across species and between ligaments. These data suggest that different types of ligament collagen, notably PDL, appear to have evolved distinctive lysine/hydroxylysine cross-linking variations. Another distinguishing feature of PDL collagen is that, unlike other ligaments, it lacks any of the known P3H2-catalyzed 3-hydroxyproline site modifications that characterize tendon and ligament collagens. This gives PDL a novel modification profile, with hybrid features of both ligament and skin collagens. Conclusion This distinctive post-translational phenotype may be relevant for understanding why some individuals are at risk of rapid PDL destruction in periodontal disease and warrants further investigation. In addition, developing a murine model for studying PDL collagen may be useful for exploring potential clinical strategies for promoting PDL regeneration.

show abstract

Mechano-regulation of collagen biosynthesis in periodontal ligament

Cited by 76 publications

References 170 publications

A paradigm shift for bone quality in dentistry: A literature review

A paradigm shift for bone quality in dentistry: A literature review

Review of common conditions associated with periodontal ligament widening

Distinct post‐translational features of type I collagen are conserved in mouse and human periodontal ligament

Contact Info

Product

Resources

About