Mechanobiologically optimized Ti–35Nb–2Ta–3Zr improves load transduction and enhances bone remodeling in tilted dental implant therapy

Mao, Chuanyuan; Yu, Weijun; Jin, Min; Wang, Yingchen; Shang, Xiaoqing; Lin, Lu; Zeng, Xiaoqin; Wang, Liqiang; Lu, Eryi

doi:10.1016/j.bioactmat.2022.03.005

Cited by 24 publications

(14 citation statements)

References 65 publications

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“…As can be seen from Figure 7 , the VECs of the discussed Bio-HEAs range from 4.0 to 5.8, among which [Ti-Zr-Hf] x ∼ (Ta-Nb-V) y fluctuate between 4.2 and 4.8 due to the generally low VECs of their constituent elements, and are primarily single BCC solid solution phases. The VEC of Bio-HEAs [Ta-Nb-V] y ∼(Mo-W) z in the high VEC element group is concentrated in the range of 5.2–5.6, mainly in the BCC phase and multiphase, where the multiphase components include Laves phase, BCC2 phase, B2 phase, FCC phase and other precipitated phases ( Wang et al, 2020 ; Mao et al, 2022 ). The interesting point is that alloys of the system [Ti-Zr-Hf] x ∼ (Mo-W) z hardly appear in the surveyed literature, implying that for Bio-HEAs, the V-subgroup elements Ta, Nb, and V with BCC lattice and high mutual solubility are indispensable.…”

Section: Component Design Theory and Simulation Studiesmentioning

confidence: 99%

Bio-high entropy alloys: Progress, challenges, and opportunities

Feng

Tang

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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With the continuous progress and development in biomedicine, metallic biomedical materials have attracted significant attention from researchers. Due to the low compatibility of traditional metal implant materials with the human body, it is urgent to develop new biomaterials with excellent mechanical properties and appropriate biocompatibility to solve the adverse reactions caused by long-term implantation. High entropy alloys (HEAs) are nearly equimolar alloys of five or more elements, with huge compositional design space and excellent mechanical properties. In contrast, biological high-entropy alloys (Bio-HEAs) are expected to be a new bio-alloy for biomedicine due to their excellent biocompatibility and tunable mechanical properties. This review summarizes the composition system of Bio-HEAs in recent years, introduces their biocompatibility and mechanical properties of human bone adaptation, and finally puts forward the following suggestions for the development direction of Bio-HEAs: to improve the theory and simulation studies of Bio-HEAs composition design, to quantify the influence of composition, process, post-treatment on the performance of Bio-HEAs, to focus on the loss of Bio-HEAs under actual service conditions, and it is hoped that the clinical application of the new medical alloy Bio-HEAs can be realized as soon as possible.

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Section: Component Design Theory and Simulation Studiesmentioning

confidence: 99%

Bio-high entropy alloys: Progress, challenges, and opportunities

Feng

Tang

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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“…The mechanical strength of metal and ceramic implants also differs significantly from that of bone (Bonfield & Grynpas, 1977). For example, titanium alloy (Ti-6Al-4 V) implants have four to five times higher elastic moduli than cortical bone (Mao et al, 2022), which generates stress at the bone-implant interface and may result in alveolar bone fractures or chips/fractures of the upper implant structure. Indeed, mechanical resistance tests using implants composed of various materials have been conducted, revealing that implants with titanium-based abutments, custom zirconia abutments, and a lithium disilicate crown exhibited significant failure with fracture against overloads.…”

Section: Problems With and Limitations Of Current Dental Implant Trea...mentioning

confidence: 99%

“…Approaches to address this issue involving the use of plastic deformation of materials have been reported, resulting in the development of the titanium alloy implant Ti-29Nb-13Ta-4.6Zr and its optimized form Ti-35Nb-2Ta-3Zr (Kuczy nska-Zemła et al, 2020;Mao et al, 2022).…”

Section: Problems With and Limitations Of Current Dental Implant Trea...mentioning

confidence: 99%

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

Saito

Onuma

Yamakoshi

2023

Genesis

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Summary The cementum is the outermost layer of hard tissue covering the dentin within the root portion of the teeth. It is the only hard tissue with a specialized structure and function that forms a part of both the teeth and periodontal tissue. As such, cementum is believed to be critical for periodontal tissue regeneration. In this review, we discuss the function and histological structure of the cementum to promote crystal engineering with a biochemical approach in cementum regenerative medicine. We review the microstructure of enamel and bone while discussing the mechanism underlying apatite crystal formation to infer the morphology of cementum apatite crystals and their complex structure with collagen fibers. Finally, the limitations of the current dental implant treatments in clinical practice are explored from the perspective of periodontal tissue regeneration. We anticipate the possibility of advancing periodontal tissue regenerative medicine via cementum regeneration using a combination of material science and biochemical methods.

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“…Biomedical metal materials are one of the ideal materials for treating bone defects because of their high strength, corrosion resistance, and biocompatibility ( Wang et al, 2020 ; Guo et al, 2022 ), but the solid metal material has a much higher elastic modulus than that of human bone, easily resulting in “stress shielding” and degradation of the bone tissue around the implant ( Geetha et al, 2009 ). The porous scaffolds can be used to replace the solid materials, which can not only reduce the elastic modulus but can also promote cell adhesion and the growth of bone tissue ( Chen et al, 2020 ; Mao et al, 2022 ). The traditional processing methods are difficult to achieve the preparation of complex porous structures, limiting the development of metal porous scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Pore Strategy Design of a Novel NiTi-Nb Biomedical Porous Scaffold Based on a Triply Periodic Minimal Surface

Liu

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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The pore strategy is one of the important factors affecting the biomedical porous scaffold at the same porosity. In this work, porous scaffolds were designed based on the triply periodic minimal surface (TPMS) structure under the same porosity and different pore strategies (pore size and size continuous gradient distribution) and were successfully prepared using a novel Ni46.5Ti44.5Nb9 alloy and selective laser melting (SLM) technology. After that, the effects of the pore strategies on the microstructure, mechanical properties, and permeability of porous scaffolds were systematically investigated. The results showed that the Ni46.5Ti44.5Nb9 scaffolds have a low elastic modulus (0.80–1.05 GPa) and a high ductility (15.3–19.1%) compared with previous works. The pore size has little effect on their mechanical properties, but increasing the pore size significantly improves the permeability due to the decrease in specific surfaces. The continuous gradient distribution of the pore size changes the material distribution of the scaffold, and the smaller porosity structure has a better load-bearing capacity and contributes primarily to the high compression strength. The local high porosity structure bears more fluid flow, which can improve the permeability of the overall scaffold. This work can provide theoretical guidance for the design of porous scaffolds.

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Mechanobiologically optimized Ti–35Nb–2Ta–3Zr improves load transduction and enhances bone remodeling in tilted dental implant therapy

Cited by 24 publications

References 65 publications

Bio-high entropy alloys: Progress, challenges, and opportunities

Bio-high entropy alloys: Progress, challenges, and opportunities

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

Pore Strategy Design of a Novel NiTi-Nb Biomedical Porous Scaffold Based on a Triply Periodic Minimal Surface

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