Mechanobiology of the Nuclear Pore Complex Machinery

Mofrad, Mohammad R. K.

doi:10.32604/mcb.2019.07429

Cited by 2 publications

(2 citation statements)

References 6 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SUN1 protein of the LINC complex directly associates with Nup153, which is involved in the correct assembly of NPC in the NE, and has a role in mRNA export. 223 NPCs also indirectly control gene expression processes by having a role in mRNA export and importing transcription factors into the nucleus. Another Nup, POM121, interact with SUN1 protein and is involved in NPC assembly during the interphase of the cell cycle.…”

Section: Nuclear Pore Complex (Npc)mentioning

confidence: 99%

“…NPCs are also linked to the nucleoskeleton by interacting with the LINC complex. The SUN1 protein of the LINC complex directly associates with Nup153, which is involved in the correct assembly of NPC in the NE, and has a role in mRNA export 223 . NPCs also indirectly control gene expression processes by having a role in mRNA export and importing transcription factors into the nucleus.…”

Section: Mechanosensing At the Nucleus: Role Of Nucleoskeletonmentioning

confidence: 99%

See 1 more Smart Citation

Mechanotransduction and epigenetic modulations of chromatin: Role of mechanical signals in gene regulation

Mishra,

Chakraborty,

Niharika

et al. 2024

J of Cellular Biochemistry

View full text Add to dashboard Cite

Mechanical forces may be generated within a cell due to tissue stiffness, cytoskeletal reorganization, and the changes (even subtle) in the cell's physical surroundings. These changes of forces impose a mechanical tension within the intracellular protein network (both cytosolic and nuclear). Mechanical tension could be released by a series of protein–protein interactions often facilitated by membrane lipids, lectins and sugar molecules and thus generate a type of signal to drive cellular processes, including cell differentiation, polarity, growth, adhesion, movement, and survival. Recent experimental data have accentuated the molecular mechanism of this mechanical signal transduction pathway, dubbed mechanotransduction. Mechanosensitive proteins in the cell's plasma membrane discern the physical forces and channel the information to the cell interior. Cells respond to the message by altering their cytoskeletal arrangement and directly transmitting the signal to the nucleus through the connection of the cytoskeleton and nucleoskeleton before the information despatched to the nucleus by biochemical signaling pathways. Nuclear transmission of the force leads to the activation of chromatin modifiers and modulation of the epigenetic landscape, inducing chromatin reorganization and gene expression regulation; by the time chemical messengers (transcription factors) arrive into the nucleus. While significant research has been done on the role of mechanotransduction in tumor development and cancer progression/metastasis, the mechanistic basis of force‐activated carcinogenesis is still enigmatic. Here, in this review, we have discussed the various cues and molecular connections to better comprehend the cellular mechanotransduction pathway, and we also explored the detailed role of some of the multiple players (proteins and macromolecular complexes) involved in mechanotransduction. Thus, we have described an avenue: how mechanical stress directs the epigenetic modifiers to modulate the epigenome of the cells and how aberrant stress leads to the cancer phenotype.

show abstract

Section: Nuclear Pore Complex (Npc)mentioning

confidence: 99%

Section: Mechanosensing At the Nucleus: Role Of Nucleoskeletonmentioning

confidence: 99%

Mechanotransduction and epigenetic modulations of chromatin: Role of mechanical signals in gene regulation

Mishra,

Chakraborty,

Niharika

et al. 2024

J of Cellular Biochemistry

View full text Add to dashboard Cite

show abstract

On modeling the multiscale mechanobiology of soft tissues: Challenges and progress

2022

View full text Add to dashboard Cite

Tissues grow and remodel in response to mechanical cues, extracellular and intracellular signals experienced through various biological events, from the developing embryo to disease and aging. The macroscale response of soft tissues is typically nonlinear, viscoelastic anisotropic, and often emerges from the hierarchical structure of tissues, primarily their biopolymer fiber networks at the microscale. The adaptation to mechanical cues is likewise a multiscale phenomenon. Cell mechanobiology, the ability of cells to transform mechanical inputs into chemical signaling inside the cell, and subsequent regulation of cellular behavior through intra- and inter-cellular signaling networks, is the key coupling at the microscale between the mechanical cues and the mechanical adaptation seen macroscopically. To fully understand mechanics of tissues in growth and remodeling as observed at the tissue level, multiscale models of tissue mechanobiology are essential. In this review, we summarize the state-of-the art modeling tools of soft tissues at both scales, the tissue level response, and the cell scale mechanobiology models. To help the interested reader become more familiar with these modeling frameworks, we also show representative examples. Our aim here is to bring together scientists from different disciplines and enable the future leap in multiscale modeling of tissue mechanobiology.

show abstract

Mechanobiology of the Nuclear Pore Complex Machinery

Cited by 2 publications

References 6 publications

Mechanotransduction and epigenetic modulations of chromatin: Role of mechanical signals in gene regulation

Mechanotransduction and epigenetic modulations of chromatin: Role of mechanical signals in gene regulation

On modeling the multiscale mechanobiology of soft tissues: Challenges and progress

Contact Info

Product

Resources

About