Mechanobiology of young and aging tendons: In vivo studies with treadmill running

Thampatty, Bhavani P.; Wang, James H-C.

doi:10.1002/jor.23761

Cited by 43 publications

(53 citation statements)

References 46 publications

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“…To address these issues, juvenile and adult frog specimens were trained on a treadmill belt on a daily basis for 2 months. Based on previous work we predict (a) that knee tissues of frogs subjected to excessive exercise will deviate from the normal and healthy state, (b) higher morphological damage in adults than in juveniles, considering that younger tissues are presumably more adaptable (Brack et al, 2007;Bailey, 2001;Clark & Ogden, 1983;Senan et al, 2011, Thampatty & Wang, 2017 and (c) more alteration in tissues in jumper species compared to walkers ones.…”

Section: Manuscript To Be Reviewedmentioning

confidence: 88%

“…These elements are excellent biological models to study the biomechanical and morphological adaptations of connective tissues to movement (Vilarta & Vidal, 1989;Feitosa, Vidal & Pimentel, 2002). The biochemical properties of tendons and other collagenous connective tissues vary with age (Thampatty & Wang, 2017), and seem to be correlated with morphological changes (Viidik, 1982;Shadwick, 1990). Previous studies usually focused on the differences in tendon properties related to age (Viidik, 1982), and on the effects of mechanical load on tendons at different ages in rats (Ingelmark, 1948), mice (Michna, 1984), humans (Kannus et al, 1997) and horses (Edwards et al, 2005).…”

Section: Manuscript To Be Reviewedmentioning

confidence: 99%

“…Although tendons show good ability to adapt to loading and movement (Kannus et al, 1997), if the tissue does not have time to repair itself it may not adjust, leading to injuries (Selvanetti, Cipolla & Puddu, 1997;Sharma & Maffulli, 2005). Tendon pathologies have been often studied in the human Aquilles tendon (Kader et al, 2002;Cook et al, 2004;Maffulli et al, 2008) and are evident in animals subjected to great mechanical loads, such as physical exercises (Kannus et al, 1997;Kraushaar & Nirshl, 1999;Thampatty & Wang, 2017). Other structures vulnerable to age and mechanical alteration of the joint environment are the menisci and the articular cartilages, that also play a key role in PeerJ reviewing PDF | (2017:10:21173:2:1:NEW 6 Aug 2018)…”

Section: Manuscript To Be Reviewedmentioning

confidence: 99%

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Peer Review #1 of "Movement and joints: effects of overuse on anuran knee tissues (v0.1)"

2018

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Movement plays a main role in the correct development of joint tissues. In tetrapods, changes in normal movements produce alterations of such tissues during the ontogeny and in adult stages. The knee-joint is ideal for observing the influence of movement disorders, due to biomechanical properties of its components, which are involved in load transmission. We analyze the reaction of knee tissues under extreme exercise in juveniles and adults of five species of anurans with different locomotion modes. We use anurans as the case study because they undergo great mechanical stress during locomotion. We predicted that a) knee tissues subjected to overuse will suffer a structural disorganization process; b) adults will experience deeper morphological changes than juveniles; and c) morphological changes will be higher in jumpers compared to walkers. To address these questions, we stimulated specimens on a treadmill belt during two months. We performed histological analyses of the knee of both treated and control specimens. As we expected, overuse caused structural changes in knee tissues. These alterations were gradual and higher in adults, and similar between jumpers and walkers species. This study represents a first approach to the understanding of the dynamics of anuran knee tissues during the ontogeny, and in relation to locomotion. Interestingly, the alterations found were similar to those observed in anurans subjected to reduced mobility and also to those described in joint diseases (i.e., osteoarthritis and tendinosis) in mammals, suggesting that among tetrapods, changes in movement generate similar responses in the tissues involved.

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Section: Manuscript To Be Reviewedmentioning

confidence: 88%

Section: Manuscript To Be Reviewedmentioning

confidence: 99%

Section: Manuscript To Be Reviewedmentioning

confidence: 99%

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Peer Review #1 of "Movement and joints: effects of overuse on anuran knee tissues (v0.1)"

2018

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“…In tendon, moderate exercise and mechanical loading negates some of the “stem cell exhaustion” associated with aging. TSC show increased expression of stem cell markers and proliferation with mechanical loading and AGEs are reduced in aged Achilles tendons after training …”

Section: Mechanisms and Manifestations Of Musculoskeletal Agingmentioning

confidence: 99%

Regulatory mechanisms and clinical manifestations of musculoskeletal aging

Grote

Reinhardt

Zhang

et al. 2019

Journal Orthopaedic Research

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Aging is the strongest risk factor for degenerative bone and joint diseases. Clinical therapies for age-related musculoskeletal disorders face significant challenges as their pathogenic mechanisms remain largely unclear. This review article focuses on the recent advances in the understanding of regulatory mechanisms of musculoskeletal aging and their clinical relevance. We begin with the prevalence and socioeconomic impacts of major age-related musculoskeletal disorders such as sarcopenia, osteoporosis, osteoarthritis, and degenerative tendinopathy. The current understanding of responsible biological mechanisms involved in general aging is then summarized. Proposed molecular, cellular, and biomechanical mechanisms relevant to the clinical manifestations of aging in the musculoskeletal system are discussed in detail, with a focus on the disorders affecting muscle, bone, articular cartilage, and tendon. Although musculoskeletal aging processes share many common pathways with the aging of other body systems, unique molecular and cellular mechanisms may be involved in the aging processes of musculoskeletal tissues. Advancements in the understanding of regulatory mechanisms of musculoskeletal aging may promote the development of novel treatments for agerelated musculoskeletal disorders. Finally, future research directions for major musculoskeletal tissues including functional interaction between the tissues and their clinical relevance to age-related musculoskeletal disorders are highlighted in the Future Prospects section. ß

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“…With this goal in mind, we are pleased to introduce this special issue in Musculoskeletal Mechanobiology. This special issue begins with several outstanding reviews that provide updates on the significance of mechanobiology in musculoskeletal research involving cartilage, tendon, muscle and bone, [1][2][3][4][5][6][7][8][9][10] and that span topics from the role of candidate mechanosensors and chemical mediators, 1,5,9,10 in vitro and in vivo models of tissue injury and repair, 3,4 and supporting technologies. 6,7 The majority of original articles following the review papers are related to the mechanobiology of bone and cartilage, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] tissues whose physical regulation have traditionally garnered intensive research focus, followed by complementary research papers in areas of growing prominence: Ligaments, intervertebral discs, and stem cells.…”

mentioning

confidence: 99%