Mechanochemical-assisted extraction of platycodin D from the roots of Platycodon grandiflorum with solid alkalis

Wu, Kejiang; Xi, Jun

doi:10.1016/j.indcrop.2019.112026

Cited by 15 publications

(7 citation statements)

References 25 publications

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“…The ball milling time is a crucial parameter for MCAE with the ionic liquid@β-cyclodextrin vesicles process. On the one hand, it has a great impact on the degree of cell disruption in the ball milling process . On the other hand, it also affects the solubilization of analytes into vesicle aggregates.…”

Section: Results and Discussionmentioning

confidence: 99%

“…This pretreatment could undoubtedly improve the water solubility, accordingly the dissolution and diffusion of analytes from the plant materials to the solvent. MCAE has gained lots of attention for its significant advantages, for example, low technological cost, high efficiency, and organic solvent exclusion. , Thanks to its remarkable superiorities, MCAE has been widely applied in the industries of food, agriculture, materials engineering, and pharmacy. − For example, Wang et al. used the MCAE method to extract two alkaloids from Fangchi .…”

Section: Introductionmentioning

confidence: 99%

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Ionic Liquid−β-Cyclodextrin Vesicle-Based Mechanochemical-Assisted Extraction for the Weak Acid Compounds from Mori Fructus

Zhu

Shi

et al. 2022

ACS Sustainable Chem. Eng.

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An ionic liquid vesicle-based mechanochemicalassisted extraction (MCAE) method was proposed for the first time and successfully applied for the extraction of weak acid compounds from Mori Fructus. The factors affecting the extraction efficiency were evaluated systematically by means of single-factor optimization and a response surface methodology, including the volume and types of vesicle solutions, milling time, solid-to-liquid ratio, and β-cyclodextrin concentration. The highest extraction yield of weak acid compounds via MCAE was obtained under optimal conditions: a vesicle volume of 318.21 μL, a milling time of 9.87 min, and a solid-to-liquid ratio of 226.07 mg mL −1 . Scanning electron microscopy and transmission electron microscopy were applied to verify the formation of vesicles and identify the physicochemical property changes during the MCAE. These changes mainly included the enhanced diffusion and dissolution of analytes resulting from the destruction of cell walls and their transfer capacities into vesicle solutions. The proposed method exhibited satisfactory linearity, with its correlation coefficients (r 2 ) larger than 0.9993, low limits of detection of 3.98−13.89 ng mL −1 , good recoveries of 84−122%, and acceptable reproducibility with relative standard deviations below 4.78%. The results indicated that the ionic liquid vesicle-based MCAE method could be a green, simple, and effective alternative for the extraction of bioactive compounds.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ionic Liquid−β-Cyclodextrin Vesicle-Based Mechanochemical-Assisted Extraction for the Weak Acid Compounds from Mori Fructus

Zhu

Shi

et al. 2022

ACS Sustainable Chem. Eng.

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“…Mechanochemical-assisted extraction was proved to be efficient with extracting PLD from roots of PG. The highest yield of PLD via mechanochemical-assisted extraction was 7.16 ± 0.14 mg/g ( Wu and Xi, 2020 ). Apart from mechanochemical-assisted extraction, abundant studies have concentrated on the extraction of PLD through enzyme biocatalysis.…”

Section: Discussionmentioning

confidence: 99%

The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus

et al. 2023

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Chinese doctors widely prescribed Platycodon grandiflorus A. DC. (PG) to treat lung carbuncles in ancient China. Modern clinical experiences have demonstrated that PG plays a crucial role in treating chronic pharyngitis, plum pneumonia, pneumoconiosis, acute and chronic laryngitis, and so forth. Additionally, PG is a food with a long history in China, Japan, and Korea. Furthermore, Platycodin D (PLD), an oleanane-type triterpenoid saponin, is one of the active substances in PG. PLD has been revealed to have anti-inflammatory, anti-viral, anti-oxidation, anti-obesity, anticoagulant, spermicidal, anti-tumor etc., activities. And the mechanism of the effects draws lots of attention, with various signaling pathways involved in these processes. Additionally, research on PLD’s pharmacokinetics and extraction processes is under study. The bioavailability of PLD could be improved by being prescribed with Glycyrrhiza uralensis Fisch. or by creating a new dosage form. PLD has been recently considered to have the potential to be a solubilizer or an immunologic adjuvant. Meanwhile, PLD was discovered to have hemolytic activity correlated. PLD has broad application prospects and reveals practical pharmacological activities in pre-clinical research. The authors believe that these activities of PLD contribute to the efficacy of PG. What is apparent is that the clinical translation of PLD still has a long way to go. With the help of modern technology, the scope of clinical applications of PLD is probable to be expanded from traditional applications to new fields.

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“…In addition, it is also worth noting that mechanochemistry is a highly reproducible, clean, versatile, and simple approach. To date, mechanochemical methods for extraction of valuable chemicals have been reported for various agricultural residues, such as Laurus nobilis L. leaves [ 25 ], Stephania tetrandra S. Moore wastes [ 26 ], and Platycodon grandiflorum [ 27 ]. Mechanochemical extraction from agricultural wastes and in-situ formation of metallic and well dispersed nanoparticles, where the extracts could participate as reducing agent and the agricultural residue as carbon source and template, certainly represent a step further for the sustainable preparation of nanomaterials [ 14 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Mechanochemical Preparation of Magnetically Separable Fe and Cu-Based Bimetallic Nanocatalysts for Vanillin Production

et al. 2021

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A highly sustainable method for the preparation of supported iron oxide and copper nanoparticles (NPs) on a biomass-derived carbon by solvent-free mechanochemical process is reported. In-situ mechanochemically obtained extracts from orange peel could behave as a green reducing agent, allowing the formation of Cu metal nanoparticles as well as generating a magnetic phase (magnetite) in the systems via partial Fe3+ reduction. At the same time, orange peel residues also served as template and carbon source, adding oxygen functionalities, which were found to benefit the catalytic performance of mechanochemically synthesized nanomaterials. The series of magnetic Cu-Fe@OP were tested in the oxidation of trans-ferulic acid towards vanillin, remarkably revealing a maximum vanillin yield of 82% for the sample treated at 200 °C.

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Mechanochemical-assisted extraction of platycodin D from the roots of Platycodon grandiflorum with solid alkalis

Cited by 15 publications

References 25 publications

Ionic Liquid−β-Cyclodextrin Vesicle-Based Mechanochemical-Assisted Extraction for the Weak Acid Compounds from Mori Fructus

Ionic Liquid−β-Cyclodextrin Vesicle-Based Mechanochemical-Assisted Extraction for the Weak Acid Compounds from Mori Fructus

The pharmacology and mechanisms of platycodin D, an active triterpenoid saponin from Platycodon grandiflorus

Mechanochemical Preparation of Magnetically Separable Fe and Cu-Based Bimetallic Nanocatalysts for Vanillin Production

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