Mechanochemical‐Induced Swelling–Activation of a Gastric‐Deployable 4D‐Printed Polypill Inspired by Natural Hygromorphic Actuators
Konstantina Chachlioutaki,
Nikolaos Papas,
Zisis Chatzis
et al.
Abstract:Gastroretentive drug delivery systems can improve adherence in patients with chronic diseases (CDs), but current options lack dose flexibility and involve complex fabrication methods. Inspired by the hygroscopic deformation observed in multilayered pine cone scales, wherein hydration of the outer active layer induces cone closure, a one‐step fabrication method of a personalized 4D‐printed water‐actuated four‐arm polypill is demonstrated in this study. The bilayer‐arm polypill self‐deploys upon ingestion to pro… Show more
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