Mechanochemical Modification of Triclabendazole for the Production of an Effective Anti-Fasciloid Drug

Abstract

Continuing a series of studies to increase the solubility of the known substance triclabendazole (TСB), the technology of mechanochemical modification was used with a mixture of polymers-polyvinylpyrrolidone (PVP) and arabinogalactan (AG) with the addition of the known emulsifier – sodium dioctyl sulfosuccinate (SDN). In this case, solid dispersions (SD) of TCB compositions were obtained: TCB : PVP = 1: 9, TCB : PVP : AG = 1: 4.5: 4.5 and TCB : PVP : AG : SDN = 1: 4.5: 4.5: 0.1, which are easily loose powders that form stable suspensions in water when preparing working solutions for use in animals. A significant improvement in the solubility (almost 30 times) of the obtained SDs with the addition of SDN was established, which allows us to hope for their high antifascioid activity. Drugs can also be used for use by adding to animal feed. Currently, the drug is being tested in laboratory and industrial conditions. According to preliminary data, drugs with the addition of SDN are of interest and additional studies are required for implementation in veterinary practice.